Results 221 to 230 of about 366,025 (373)

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

Oncogene, 2010
Anurag Singh, J. Settleman
semanticscholar   +1 more source

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science, EarlyView.
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
wiley   +1 more source

Conserved stromal EMT program controls regenerative capacity of mesenchymal stromal cells across multiple tissues. [PDF]

Sci Adv
Kim JA, Park BW, Lee HR, Jung GA, Lee S, Sim WS, Lee H, Kim J, Shin S, Lee C, Park S, Kang YJ, Lee JW, Kim HJ, Kwon YK, Park HJ, Oh IH.   +16 more
europepmc   +1 more source

Spermine attenuates TGF-β-induced EMT by downregulating fibronectin [PDF]

Huidong Liu, Ye-Guang Chen
openalex   +1 more source

Microenvironment‐Guided Evolution of ssDNA‐SWCNT Probes for Selective Recognition of Aggressive Prostate Cancer Phenotypes

Advanced Science, EarlyView.
Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee, Seok‐Hyeon Lee, Yunseo Jung, Jeongho Lee, Min‐Seo Choi, SaeOck Oh, Sungjee Kim, Byoung Soo Kim, Sanghwa Jeong   +8 more
wiley   +1 more source

Integrative Spatial Transcriptomics and Experimental Validation Reveal UBC-Mediated EMT Associated with Immune Evasion in Hepatocellular Carcinoma. [PDF]

Immunotargets Ther
Li X, Qin X, Shi K, Lu G, Tian G, Chen Y, Yao R.   +6 more
europepmc   +1 more source

Mathematical strategies for predicting resistant subpopulations from scRNAseq data of a PANC-1 3D tissue model: Insight into gemcitabine resistance and TGFB1-induced invasion and EMT

Aylin Caliskan, Samantha A. W. Crouch, Jesús Guillermo Nieves Pereira, Thomas Dandekar, Gudrun Dandekar, Tim Breitenbach   +5 more
openalex   +1 more source

Micro‐Organ Chip Deciphers Tumor‐Derived G‐CSF as Remote Commander of Lung Pre‐Metastatic Niche via VEGFA‐KDR Cascade

Advanced Science, EarlyView.
Breast cancer reprograms the lung into a receptive pre‐metastatic niche via a novel G‐CSF–VEGFA–KDR signaling axis. Using a micro‐organ chip that enables contact‐independent coculture, this study uncovers how tumor‐secreted G‐CSF activates lung capillary KDR to drive angiogenesis and prime the soil for metastasis—without direct tumor contact.
Jingxin Zhang, Xiaoying Huang, Lingchuan Ma, Zixing Chen, Tianyao Li, Lijian Wang, Yutong Guo, Hu Xu, Junqi Li, Jiang‐Jiang Qin, Xiang Wang, Yuhong Cao, Kai Miao   +12 more
wiley   +1 more source

Overexpression of EMT-related transcription factors SNAI1 and ZEB1 is associated with more aggressive clinicopathological features of pancreatic cancer. [PDF]

PLoS One
Urbonas K, Stachneviciute G, Jasukaitiene A, Ignatavicius P, Dambrauskas Z, Gulbinas A, Barauskas G.   +6 more
europepmc   +1 more source

MCF-7 Cells Expressing Nuclear Associated Lysyl Oxidase-like 2 (LOXL2) Exhibit an Epithelial-to-Mesenchymal Transition (EMT) Phenotype and Are Highly Invasive in Vitro [PDF]

, 2013
Hee-Jung Moon, Joel Finney, Li Xu, David Moore, Danny R. Welch, Minae Mure   +5 more
openalex   +1 more source