Results 1 to 10 of about 50,888 (242)

Simultaneous Semi-Mechanistic Population Pharmacokinetic Modeling Analysis of Enalapril and Enalaprilat Serum and Urine Concentrations From Child Appropriate Orodispersible Minitablets [PDF]

Frontiers in Pediatrics, 2019
Enalapril is recommended as the first line of therapy and is proven to improve survival rates for treatment of Pediatric Heart Failure; however, an approved drug and child appropriate dosage formulation is still absent. The present analysis was conducted
Muhammad Faisal, Willi Cawello, Bjoern B. Burckhardt, Jan de Hoon, Stephanie Laer, LENA Consortium   +5 more
doaj   +2 more sources

Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes [PDF]

eLife
Aging increases the risk of a myriad of chronic diseases, which are expensive and difficult to treat owing to their various risk factors. Repurposing existing medications has accelerated the development of therapies aimed at slowing aging. In this study,
Wencong Lyu, Haochen Wang, Zhehao Du, Ran Wei, Jianuo He, Fanju Meng, Jinlong Bi, Lijun Zhang, Chao Zhang, Yiting Guan, Wei Tao   +10 more
doaj   +2 more sources

Synergistic protective effects of remote ischemic postconditioning and enalapril on endothelial dysfunction in spontaneously hypertensive rats via inhibition of oxidative stress-mediated mitochondrial dysfunction

Blood Pressure
Purpose Hypertension-induced vascular injury involves endothelial dysfunction, inflammation, oxidative stress, and mitochondrial damage. While remote ischaemic postconditioning (RIPost) and Enalapril independently offer vascular protection, their ...
Wanfu Cui, Dan Rong, Peng Qu, Qinglei Zhong, Miaolei Gao, Xinzhu Tong   +5 more
doaj   +2 more sources

Safety and Efficacy of Enalapril Combined with Metoprolol in Patients of Hypertension Complicated with Coronary Heart Disease: A Randomised Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Enalapril, which inhibits Angiotensin-Converting Enzyme (ACE), is a commonly used drug for the treatment of hypertension. Metoprolol, a β-blocker, is widely prescribed for patients with cardiac diseases.
Ping Wang, Lijun Wang, Zhihui Liu, JI Feng   +3 more
doaj   +1 more source

Evaluation of the Hepatotoxicity Induced by Captopril and Enalapril in Rat Liver: A Comparative Study [PDF]

Basrah Journal of Veterinary Research, 2023
The aim of this study was to look into the toxicity of captopril and enalapril in high doses in the liver. The animals in this experiment were divided into five groups of ten each, with the first group serving as a control group, receiving only distilled
Mohammed Ibrahim, Waseem Hassan Hassan, Mohammed Saeed   +2 more
doaj   +1 more source

Cost-effectiveness of folic acid therapy for primary prevention of stroke in patients with hypertension

BMC Medicine, 2022
Background For hypertensive patients without a history of stroke or myocardial infarction (MI), the China Stroke Primary Prevention Trial (CSPPT) demonstrated that treatment with enalapril-folic acid reduced the risk of primary stroke compared with ...
Tiantian Zhang, Zhuoru Liang, Tengfei Lin, David J. Cohen, Alejandro Arrieta, Xiaobin Wang, Xianhui Qin, Binyan Wang, Yong Huo, Gordon G. Liu, Jie Jiang, Zugui Zhang   +11 more
doaj   +1 more source

Effect of moxifloxacin on pharmacokinetics of enalapril in rats [PDF]

E3S Web of Conferences, 2021
The purpose of this study was to investigate the effect of moxifloxacin on the pharmacokinetics of enalapril. Single administration experiment: 12 Wistar rats were randomly divided into two groups on average.
Jing Zhao, Jiarui Peng, Yinxia Zhang
doaj   +1 more source

COMPARISON OF PHARMACOKINETICS AND PHARMACODYNAMICS OF THE ORIGINAL AND GENERIC ENALAPRIL IN THE ELDERLY PATIENTS WITH ARTERIAL HYPERTENSION

Рациональная фармакотерапия в кардиологии, 2015
Aim. To study the pharmacokinetic, pharmacodynamic and pharmacoeconomic parameters of the original and generic enalaprils in the treatment of the elderly patients with hypertension (HT). Material and Methods.
O. P. Bobrova, M. M. Petrova
doaj   +3 more sources

Enalapril: Synthesis and properties [PDF]

Hemijska Industrija, 2004
Enalapril was originally synthesized by Merck Sharp and Dohme and is an angiotensin converting enzyme inhibitor. Thus, enalapril is used in the treatment of mild to severe hypertension. Enalapril is chemically (S)-1-[N-[1-(et-hoxycarbonyl)-3-phenylpropyl]
Mijin Dušan Ž., Stanković Milena, Petrović Slobodan D.   +2 more
doaj   +1 more source

Study of dissolution profiles of Аmlodipine tablets with enalapril

Ukrainian Scientific Medical Youth Journal, 2022
quality assurance in the production of medicines is a comprehensive concept. The quality of medicines must be guaranteed at all stages of production - from development, research and production to implementation and optimal use.
Nataliia Behei, Oksana Tryhubchak
doaj   +1 more source