Results 41 to 50 of about 23,620 (209)

Projecting the benefit of vericiguat in PARADIGM‐HF and DAPA‐HF populations: Insights from the VICTORIA trial

ESC Heart Failure, Volume 12, Issue 2, Page 1479-1484, April 2025.
Abstract Aims The VICTORIA trial demonstrated a significant reduction in the primary composite outcome of heart failure (HF) hospitalization or cardiovascular death with vericiguat relative to placebo in high‐risk HF. This study aimed to contextualize treatment effects of vericiguat in populations with varying risk profiles simulated from the PARADIGM ...
Veraprapas Kittipibul, Robert J. Mentz, Rebecca Young, Javed Butler, Justin A. Ezekowitz, Carolyn S.P. Lam, Piotr Ponikowski, Adriaan Voors, Stefano Corda, Ciaran McMullan, Christopher M. O'Connor, Kevin J. Anstrom, Paul W. Armstrong, for the VICTORIA Study Group   +13 more
wiley   +1 more source

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan, Meryem İlkay Karagül, Hatice Oruç Demirbağ, Ebru Balli   +3 more
wiley   +1 more source

Influence of combined antihypertensive therapy on plasmatic,vascular-thrombocytic hemostasis and lipid peroxidation in patientswith metabolic syndrome and arterial hypertension

Бюллетень сибирской медицины, 2007
The impact of antihypertensive therapy with the angiotensin-converting enzyme inhibitor enalapril (enap) and with enalapril in combination with the long-acting calcium channel blocker verapamil SR (isoptin SR) on changes of plasmatic, vascular ...
N. M. Krasnova, E. A. Bushkova
doaj   +1 more source

ACE‐inhibitory peptide Leu‐Tyr‐Ala in skeletal muscle actin exhibits anti‐aging effects through the inhibition of acn‐1 in Caenorhabditis elegans

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Inhibitors of angiotensin‐converting enzyme (ACE) are used in pharmaceuticals and functional foods. Captopril, a well‐known ACE inhibitor, extends the lifespan of the nematode Caenorhabditis elegans. Bioactive peptides derived from food sources are considered safe ACE inhibitors.
Issei Yokoyama, Minori Yamane, Kanaho Watanabe, Abdul Fatah, Yusuke Komiya, Jun Nagasao, Keizo Arihara   +6 more
wiley   +1 more source

Avaliação da qualidade de cápsulas manipuladas de antihipertensivos: validação de metodologias analíticas: Titulométrica, espectrofotométrica e cromatográfica [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.O presente trabalho apresenta metodologias de avaliação dos parâmetros qualitativos e quantitativos de cápsulas de três ...
Külkamp, Irene Clemes
core  

Análisis coste efectividad del tratamiento con, enalapril de la insuficiencia cardíaca crónica n en españa

, 1996
SummaryThe aim of this study is to analyse in terms of cost-effectiveness the utilisation of enalapril as part of chronic heart failure therapy in Spain.
Antón Botella, F., Echevarría Echarri, L., Antoñanzas Villar, F., Antoñanzas Villar, F. [0000-0001-6122-9130]   +3 more
core   +1 more source

The effect of antihypertensive treatment on longitudinal changes in PLGF and sFlt‐1 in women with new onset hypertension in pregnancy

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In pregnant women with new‐onset hypertension starting antihypertensives, some achieve tight BP control within a week (Group 1‐blue line), while others respond slower (Group 2‐red line). Group 1 showed higher Log10PLGF levels, but Log10sFlt‐1 did not differ between groups. Over time, Log10PLGF declined in both groups, while Log10sFlt‐1 remained stable.
Edward Tyrell, Katherine G. Y. Lau, Martyna Bednorz, Kypros H. Nicolaides, Nikos A. Kametas   +4 more
wiley   +1 more source

Simultaneous Semi-Mechanistic Population Pharmacokinetic Modeling Analysis of Enalapril and Enalaprilat Serum and Urine Concentrations From Child Appropriate Orodispersible Minitablets

Frontiers in Pediatrics, 2019
Enalapril is recommended as the first line of therapy and is proven to improve survival rates for treatment of Pediatric Heart Failure; however, an approved drug and child appropriate dosage formulation is still absent. The present analysis was conducted
Muhammad Faisal, Willi Cawello, Bjoern B. Burckhardt, Jan de Hoon, Stephanie Laer, LENA Consortium   +5 more
doaj   +1 more source

Hot-Melt Extrusion of the Thermo-Sensitive Peptidomimetic Drug Enalapril Maleate

Pharmaceutics, 2022
The aim of this research was the production of extrudates for the treatment of hypertension and heart failure and the investigation of the degradation of the peptidomimetic drug enalapril maleate (EM) during hot-melt extrusion (HME).
Lena Hoffmann, Jörg Breitkreutz, Julian Quodbach   +2 more
doaj   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source