Results 81 to 90 of about 50,888 (242)

Efficacy of pimobendan in the prevention of congestive heart failure or sudden death in doberman pinschers with preclinical dilated cardiomyopathy (the PROTECT study) [PDF]

, 2012
<p>Background: The benefit of pimobendan in delaying the progression of preclinical dilated cardiomyopathy (DCM) in Dobermans is not reported.</p> <p>Hypothesis: That chronic oral administration of pimobendan to Dobermans with ...
Boswood, A., Braz-Ruivo, L., Culshaw, G.J., Dukes-McEwan, J., Estrada, A., French, A.T., Gordon, S.G., Loureiro, J., O'Grady, M.R., O'Sullivan, M.L., Oyama, M.A., Patteson, M., Smith, A., Summerfield, N.T., Watson, P.J., Willis, R.   +15 more
core   +3 more sources

Physiologically‐Based Pharmacokinetic Modeling of the PARP Inhibitor Niraparib

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT A physiologically‐based pharmacokinetic (PBPK) model of niraparib and its primary metabolite using a relevant virtual cancer population is reported here. A series of in vitro experiments using liver S9, microsomes, and hepatocytes with various inhibitors and recombinant supersomes demonstrated that niraparib is specifically metabolized by ...
Gareth J. Lewis, Roxanne C. Jewell, Anu Shilpa Krishnatry, Kunal S. Taskar   +3 more
wiley   +1 more source

Enalapril e captopril revertem o edema e a hiperplasia renais causados pelo antimoniato de N-metilglucamina em camundongos C57BL/6

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2016
The aim of this study was to verify whether enalapril and captopril would reverse the renal damage caused by N-methylglucamine antimoniate in C57BL/6 mice. We used inbred C57BL/6 female mice, obtained from the Oswaldo Cruz Foundation (FIOCRUZ), Salvador,
S.S. Oliveira, L.L. Lopes, A.S. Damazo, D. Albuquerque   +3 more
doaj   +1 more source

Sequential Event Rate Monitoring

Statistics in Medicine, Volume 45, Issue 1-2, January 2026.
ABSTRACT Effective monitoring of event rates is essential for maintaining statistical power and study integrity in clinical trials, particularly when the primary endpoint involves time‐to‐event outcomes. We propose Sequential Event Rate Monitoring (SERM), a new and innovative approach for continuous monitoring of event rates.
Dong‐Yun Kim, Sung‐Min Han
wiley   +1 more source

Pancreatic ductal adenocarcinoma [PDF]

, 2013
A 61-year-old gentleman who lives with his wife and 20-year-old son, presented to the polyclinic with a four week history of pruritus. On examination he was found to be jaundiced and his LFTs were high.
Bezzina, Sarah, Debattista, Daniel
core  

Hyperfiltration and Metabolism Before and After a Low‐Calorie, Pre‐Gastric Bypass Surgery Diet: Significance for Concentrations of Hydrophilic and Lipophilic Drugs

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.
ABSTRACT Psychotropic drug concentrations increase/decrease with hydrophilicity/lipophilicity after a low‐calorie pre‐bariatric surgery diet. To investigate underlying mechanisms, body weight and serum creatinine/cystatin C changes over the diet period were characterized and suggested to reflect changes in glomerular filtration and metabolic capacity ...
Magnus A. B. Axelsson, Susanna M. Wallerstedt   +1 more
wiley   +1 more source

Enalapril therapy and thrombotic and inflammatory abnormalities in essential arterial hypertension

Кардиоваскулярная терапия и профилактика, 2005
Aim. During enalapril therapy in essential arterial hypertension (EAH) patients, to assess correction of the factors determining arterial thrombosis and inflammatory changes in arterial wall. Material and methods.
O. M. Moiseeva, O. A. Berkovich, S. V. Villevalde, I. V. Emelyanov   +3 more
doaj  

Risk of hyperkalemia in patients with moderate chronic kidney disease initiating angiotensin converting enzyme inhibitors or angiotensin receptor blockers : a randomized study [PDF]

, 2013
Background: Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers are renoprotective but both may increase serum potassium concentrations in patients with chronic kidney disease (CKD).
A Mimran, A Rastegar, AS Levey, B Pitt, Berta Renedo, BF Palmer, BF Palmer, BL Svarstad, BM Brenner, BS Heran, CE Mogensen, CR Moore, Daniel Serón, DB Mount, DE Morisky, E Espinel, E Porteri, EJ Lewis, EJ Lewis, Eugenia Espinel, FF Hou, G Mancia, G Maschio, GD Sanders, GL Bakris, HH Parving, Iván Gil, J Yasky, Joan Fort, Jorge Joven, K Takaichi, LC Reardon, MJ Fabia, MR Weir, MR Weir, MS Stevens, N El-Sherif, P Sharma, PH Pun, Pilar Suñé, PR Jarman, RA Preston, RS Mckelvie, RT Gansevoort, S De Denus, S Korgaonkar, S Kuriyama, S Omboni, S Oparil, SA Hunt, SP Crispim, SP Ponce, TH Jafar   +52 more
core   +1 more source

Pharmacotherapy Risks in Rare Genetic Diseases: Cross‐Referencing ACMG Secondary Findings v3.2 List With Clinical Databases

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Clinical genomics and pharmacogenomics have largely remained separate fields, though some genetic variants have overlapping disease risk and drug implications. However, the extent of this overlap is not well studied. To explore this gap, we cross‐referenced genes from the American College of Medical Genetics Secondary Findings v3.2 list with ...
Josiah D. Allen, Benjamin Q. Duong, Jordan Brady, Pamela Arn   +3 more
wiley   +1 more source

Gene Expression in Experimental Aortic Coarctation and Repair: Candidate Genes for Therapeutic Intervention? [PDF]

, 2015
Coarctation of the aorta (CoA) is a constriction of the proximal descending thoracic aorta and is one of the most common congenital cardiovascular defects.
Bozdag, Serdar, Eddinger, Thomas J., Kersten, Judy R., LaDisa, John F., Jr., Olson, Jessica, Ramchandran, Ramani   +5 more
core   +3 more sources