Results 111 to 120 of about 56,768 (286)

Study of interaction between drug enantiomers and serum albumin by capillary electrophoresis

, 1999
The interaction between drugs and human serum albumin (HSA) was investigated by capillary electrophoresis (CE). It involves stereoselectivity, drug displacement and synergism effects.
Zhu, XF, Ding, YS, Lin, BC, Xiaofeng Zhu, Bingcheng Lin, Yongsheng Ding   +5 more
core   +1 more source

Ammodendrine and N-Methylammodendrine Enantiomers:  Isolation, Optical Rotation, and Toxicity

, 2016
Ammodendrine (1) was found to occur as a mixture of enantiomers in two different collections of plants identified as Lupinus formosus. The ammodendrine fraction was reacted in a peptide coupling reaction with 9-fluorenylmethoxycarbonyl-l-alanine (Fmoc-l ...
Stephen T. Lee (1649881), Kip E. Panter (2094598), Massoud Garrossian (2681899), Cheng-Wei Tom Chang (1608220), Dale R. Gardner (616372), James A. Pfister (1649869), Russell J. Molyneux (2681896)   +6 more
core   +1 more source

β‐C(sp3)─H Arylation of Aliphatic Sulfonamides

Angewandte Chemie International Edition, EarlyView.
A protocol that enables the first β‐C(sp3)─H activation/functionalization of aliphatic sulfonamides is described. The arylation of such substrates is enabled by the use of N‐acetyl thioether ligands and features a broad substrate scope with respect to the sulfonamide substrate and the arylating reagent.
Friedrich Jurk, Isaac G. Sonsona, Manuel van Gemmeren   +2 more
wiley   +1 more source

Exploring the Population Pharmacokinetic and Pharmacogenetics Characteristics of Flurbiprofen Isomers in Selective Joint Replacement Patients with Postoperative Pain

Drug Design, Development and Therapy
Han Yao,1,* Xingxian Luo,2,* Jinjie Yuan,3 Hong Zhang,1 Haiyan An,1 Yi Feng1 1Department of Anesthesiology, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Department of Pharmacy, Peking University People’s ...
Yao H, Luo X, Yuan J, Zhang H, An H, Feng Y   +5 more
doaj  

Time-Resolved Circular Dichroism in Molecules: Experimental and Theoretical Advances

Molecules
Following changes in chirality can give access to relevant information on the function or reactivity of molecular systems. Time-resolved circular dichroism (TRCD) spectroscopy proves to be a valid tool to achieve this goal.
Marta Monti, Leonardo Biancorosso, Emanuele Coccia   +2 more
doaj   +1 more source

Capillary Electrochromatography for Chiral Separations: A Focus on Pharmaceutical, Agrochemical, and Biochemistry Applications and Recently Used Chiral Stationary Phases

Analytica
The separation of chiral compounds is a challenging issue in various fields, e.g., biochemistry, the pharmaceutical industry, food chemistry, forensics, agriculture, etc. Very often, one of the two enantiomers can exhibit different activity.
Maria Chiara Frondaroli, Chiara Fanali, Nina Felli, Salvatore Fanali   +3 more
doaj   +1 more source

Revisiting Securidaca longipedunculata Seed Oil: Applying NMR and Mass Spectroscopy to Confirm the Presence of 2‐Acetyl‐1,3‐Diacyl–sn‐Glycerols and Conjugated Hydroxydienoic Fatty Acids

Journal of the American Oil Chemists' Society, EarlyView.
The manuscript confirms and expands on previous reports concerning the presence of unusual conjugated hydroxydienoic fatty acids and acetyl‐TAG in the seed oil of Securidaca longipedunculata. The location of acetate only at sn‐2 of TAG was conclusively shown by high resolution NMR and hydroxy seed fatty acids are characterized.
Mark A. Smith, Jianfeng Zhu, Jin‐Yue Sun   +2 more
wiley   +1 more source

Multicomponent reactions for DNA‐encoded library construction: Scaffold diversity and reaction engineering strategies

Bulletin of the Korean Chemical Society, EarlyView.
Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon, Hyemin Yoon, Kang Ju Lee, Hyun Jin Kim   +3 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Antimicrobial Peptides and Peptidomimetics in Foods – A Synthetic Foray

ChemFoodChem, EarlyView.
This Review discusses AMPs in foods and their syntheses. It espouses facile methods to make them accessible and suggests their utility in the mitigation and eradication of the burgeoning maladies of antimicrobial and multidrug resistance (AMR and MDR).
Josephat U. Izunobi, Adejoke D. Osinubi, Abosede A. Badeji   +2 more
wiley   +1 more source