Results 131 to 140 of about 56,768 (286)

A Trans‐1,2‐Diphenyl‐Substituted EDTA Platform for High‐Relaxivity Mn(II) MRI Probes

open access: yesChemistry – A European Journal, EarlyView.
Symmetric diphenyl substitution of the EDTA backbone enhances the rigidity of the Mn(II) complex and enables strong multisite interactions, providing a versatile platform for further functionalisation and conjugation towards high‐performance Mn(II)‐based MRI contrast agents.
Federico Forgione   +7 more
wiley   +1 more source

Recent Progress in Detecting Enantiomers in Food

open access: yes
The analysis of enantiomers in food has significant implications for food safety and human health. Conventional analytical methods employed for enantiomer analysis, such as gas chromatography and high-performance liquid chromatography, are characterized ...
Changlong Hao
core   +1 more source

Peroullazines: Synthesis, Structure, and Optoelectronic Properties

open access: yesChemistry – A European Journal, EarlyView.
Peroullazines, longitudinally π‐extended ullazines featuring a peropyrene‐sized framework, are more electron‐rich than the corresponding peropyrene systems and exhibit optical gaps approaching those of teropyrenes. Regioselective pyridinic nitrogen incorporation further enables frontier‐orbital‐controlled tuning of their optoelectronic properties ...
Ricardo Molenda   +3 more
wiley   +1 more source

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul   +5 more
wiley   +1 more source

Nadifloxacin: Multimilligram Enantioresolution and Enantioselective Ecotoxicological Studies. [PDF]

open access: yesChirality
Oliveira IE   +9 more
europepmc   +1 more source

Tramadol Co‐Administration with Oxycodone or Hydrocodone Increases Opioid Burden without Improving Postoperative Pain Control

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Tramadol is frequently co‐prescribed with oxycodone or hydrocodone after surgery under the assumption that its dual mechanism of action provides an opioid‐sparing benefit. However, evidence supporting this practice is limited and inconsistent. We conducted a secondary analysis of the multicenter IGNITE ADOPT‐PGx pragmatic trial of patients undergoing ...
Noor A. Nahid   +302 more
wiley   +1 more source

Reprocessing Mass Spectra from Therapeutic Drug Monitoring to Unveil Proton Pump Inhibitor Use and Quantify Phenoconversion of Escitalopram Metabolism in CYP2C19‐Genotyped Patients

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Escitalopram is a frequently prescribed antidepressant drug. CYP2C19 genotype is a major determinant of escitalopram metabolism and treatment outcome. However, real‐life studies show a high degree of genotype–phenotype mismatch in escitalopram metabolism.
Kristine Hole   +3 more
wiley   +1 more source

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