Results 131 to 140 of about 48,679 (293)
Chiral Chromenes: Synthesis, Separation of Enantiomers and Barriers to Racemization
, 1993 2ff-Chromenes 3 and 4 have been synthesized by reduction of the appropriate lactone with diisobutylaluminium hydride and subsequent O-alkyla- tion of the resulting lactols.
Mannschreck, Albrecht +14 more
core +1 more source
Pharmacokinetic Differences Between Lansoprazole Enantiomers in Rats
, 1998 Because limited information is available about potential differences between the pharmacokinetics and pharmacodynamics of the enantiomers of lansoprazole, the enantioselective pharmacokinetics of the compound have been investigated in rats.
Kazuto Yasuda +3 more
core +1 more source
The separation of specific enantiomers of anticancer reagent cytarabine using HPLC.
During the research and development stage of any drug candidate, there is a growing need to investigate the properties of existing enantiomers, if the drug possesses chirality.
Kamble, Shweta Ashok
core
Drug Design, Development and TherapyHan Yao,1,* Xingxian Luo,2,* Jinjie Yuan,3 Hong Zhang,1 Haiyan An,1 Yi Feng1 1Department of Anesthesiology, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Department of Pharmacy, Peking University People’s ...
Yao H +5 more
doaj
Drugs and Drug CandidatesThe review explores the critical role of chirality in the pharmacology of antidepressant drugs, focusing on how the stereochemistry of these compounds influences their biological activity and therapeutic outcomes.
Gabriel Hancu +2 more
doaj +1 more source
In pharmaceutical R & D, drug stereochemistry, and consequently the rotation of enantiomers, is very important. Because they act as chiral selectors in vivo, biomacromolecules have been extensively used as chiral selectors for the liquid chromatographic (
Salmon, Andrew B
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A Chiral Saddle‐Shaped Nanographene With Two Heptagon‐Embedded [4]Helicenes
Angewandte Chemie International Edition, EarlyView.We present a novel synthetic strategy toward a chiral saddle‐shaped nanographene (cSNG) via a two‐step oxidation of a prochiral anthracene precursor. The Scholl‐type oxidation first yields a key intermediate with sp3‐defect heptagons, and subsequent oxidative dehydrogenation affords fully conjugated cSNG.
Felix Trautner +11 more
wiley +1 more source
Affinity of Rimantadine Enantiomers against Influenza A/M2 Protein Revisited
, 2017 Recent findings from solid state NMR (ssNMR) studies suggested that the (R)-enantiomer of rimantadine binds to the full M2 protein with higher affinity than the (S)-enantiomer.
Jun Wang (5906) +9 more
core +1 more source
11-Hydroxyeicosatetraenoics induces cellular hypertrophy in an enantioselective manner
Frontiers in PharmacologyBackgroundR/S enantiomers of 11-hydroxyeicosatertraenoic acid (11-HETE) are formed from arachidonic acid by enzymatic and non-enzymatic pathways. 11-HETE is predominately formed by the cytochrome P450 1B1 (CYP1B1).
Sara A. Helal +3 more
doaj +1 more source
Plasma-Protein Binding of the Enantiomers of Hydroxychloroquine and Metabolites
, 1993 The in vitro binding of the enantiomers of hydroxychloroquine and its three major metabolites in pooled plasma obtained from four healthy volunteers and the binding of the enantiomers of hydroxychloroquine to purified plasma proteins has been ...
Tett, SE, McLachlan, AJ, Cutler, DJ
core +1 more source