Results 91 to 100 of about 1,028 (242)
Acta Crystallographica Section D, EarlyView.A structure of the flavin‐dependent single‐component tryptophan halogenase AetF bound to the non‐native tricyclic substrate tryptoline reveals a binding pose analogous to l‐tryptophan that directs C6‐first halogenation. Product analysis identifies 6,8‐dibromotryptoline as the final product.Flavin‐dependent halogenases (FDHs) offer a biocatalytic route ...
Simon Bork +3 more
wiley +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Field-effect sensitivity enhanced bilayer chiral sensor
, 2008 Organic thin-film transistor sensors have been recently attracting the attention of the plastic electronics community for their potential exploitation in novel sensing platforms.
P. G. ZAMBONIN +9 more
core
Enzyme–MOF Composites: Quantitative Benchmarking and Evaluation of Biocatalyst Performance
Advanced Synthesis &Catalysis, Volume 368, Issue 13, 2 July 2026.Rigorous evaluation of enzyme@MOF composites requires quantitative benchmarking. This study illustrates this approach by applying and comparing enzyme‐loading and activity‐assessment strategies for two structurally and functionally distinct enzymes, phenolic acid decarboxylase, and cytochrome c.
Annika J. Weber +9 more
wiley +1 more source
Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods
Chirality, Volume 38, Issue 7, July 2026.Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz +1 more
wiley +1 more source
Chirality, Volume 38, Issue 7, July 2026.A practical and straightforward approach to optically active erythro 3‐amino‐2‐hydroxy acids and its application to the enantioselective synthesis of 3‐phenylisoserine and of the marine natural product 3‐amino‐2‐hydroxy‐6‐methylheptanoic acid is reported.
Marilena Caporale +4 more
wiley +1 more source
Supramolecular Aggregates of Amino Acid‐Functionalized 1,8‐Naphthalimides for Chiral Recognition
Chemistry–Methods, Volume 6, Issue 7, July 2026.We synthesized three self‐assembling, amino acid‐functionalized 1,8‐naphthalimides. We studied their aggregation in solution and demonstrated their chiral recognition ability by fluorescence and resonance light scattering measurements. Notably, these fluorescent probes maintain their chiral recognition ability when incorporated in solid supports like ...
Salvatore Marullo, Francesca D’Anna
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis +2 more
wiley +2 more sources
Flavour Ester Synthesis by Immobilized Lipases: A Research Overview With Industrial Relevance
Flavour and Fragrance Journal, Volume 41, Issue 4, Page 721-741, July 2026.Research landscape of flavour ester synthesis by immobilized lipases, highlighting enzymatic routes, major research themes and aspects related to industrial relevance, including enzyme reuse, solvent‐free systems, process intensification and scale‐up potential.
Nicole Marasca +3 more
wiley +1 more source
Magnetic Resonance in Chemistry, Volume 64, Issue 7, Page 621-628, July 2026.TR‐NOAH‐NUS enables real‐time reaction monitoring and direct structural characterization of transient intermediates. Integration of NOAH supersequences with t0‐filling minimizes reaction monitoring deadtime and provides high temporal resolution for kinetic analysis.
Sara M. Guzman +4 more
wiley +1 more source