Results 61 to 70 of about 52,821 (176)

Eugenol‐Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Arboviruses represent an ongoing global health challenge, particularly in tropical regions where diseases caused by Chikungunya virus (CHIKV) and Mayaro virus (MAYV) continue to emerge. Given the absence of licensed antiviral therapies, the identification of effective small molecules remains critical.
Adriana Cotta Cardoso Reis, Amália Luíza de Sousa da Silva, Camila Portruneli, Augusto Vieira Pontes Silva, Saulo Fehelberg Pinto Braga, Igor Rodrigues Lapa, Thiago Belarmino de Souza, Lucas Lopardi Franco, Diogo Teixeira Carvalho, Geraldo Célio Brandão   +9 more
wiley   +1 more source

Insights into adjunctive corticosteroid therapy in fulminant herpes simplex virus encephalitis: case analysis with contrasting outcomes [PDF]

Herpes simplex virus (HSV) encephalitis, predominantly caused by HSV-1, presents with significant morbidity and mortality challenges. This research investigates the particular role of adjunctive corticosteroid therapy in fulminant HSV encephalitis ...
Nawal Abdelghaffar, Hussein Algahtani, Bader Shirah, Hussam A. Jamaluddin   +3 more
core   +2 more sources

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
core   +1 more source

Mono-WNV and combined WNV/TBEV inactivated vaccine efficacy against a wide range of WNV and TBEV strains

Frontiers in Immunology
West Nile virus (WNV) is widespread throughout the world. Occasionally, it causes outbreaks of the West Nile fever (WNF) disease, which can lead to severe CNS damage or death.
Ksenia Tuchynskaya, Mikhail Vorovitch, Mikhail Vorovitch, Yuriy Kruglov, Guzal Mostipanova, Ivan Kholodilov, Alla Ivanova, Victoria Kuchina, Anastasia Rogova, Galina Karganova, Galina Karganova   +10 more
doaj   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Exploring Genomic, Geographic and Virulence Interactions among Epidemic and Non-Epidemic St. Louis Encephalitis Virus (Flavivirus) Strains. [PDF]

PLoS ONE, 2015
St. Louis encephalitis virus (SLEV) is a re-emerging arbovirus in South America. In 2005, an encephalitis outbreak caused by SLEV was reported in Argentina.
Luis A Diaz, Sandra E Goñi, Javier A Iserte, Agustín I Quaglia, Amber Singh, Christopher H Logue, Ann M Powers, Marta S Contigiani   +7 more
doaj   +1 more source

Molecular and Serological Screening of West Nile and Usutu Virus in Birds and Humans: A Sentinel Study in Finland

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
We developed sensitive real‐time PCR assays for West Nile virus and Usutu virus to screen bird and human samples in Finland. Although no positive samples were detected, active migratory flyways and recent cases in neighbouring countries highlight the risk of future introduction and the need for continued surveillance.
Ruut Joensuu, Maija T. Suvanto, Sanna Sainmaa, Viktor Olander, Roope Nykänen, Essi M. Korhonen, Anne J. Jääskeläinen   +6 more
wiley   +1 more source

The impact of temperature and insect-specific viruses on the transmission of alphaviruses by Aedes japonicus japonicus

Microbiology Spectrum
Arthropod-borne virus (arbovirus) infections are increasing globally, and invasive mosquito species are spreading. Since the end of the last century, Aedes japonicus has continued to spread in Europe as well as in North America.
Stephanie Jansen, Dániel Cadar, Jana Christina Hey, Michelle Helms, Unchana Lange, Balázs Horváth, Hanna Jöst, Wolf-Peter Pfitzner, Jonas Schmidt-Chanasit, Renke Lühken, Anna Heitmann   +10 more
doaj   +1 more source

Mosquito feeding patterns in the context of West Nile and eastern equine encephalitis viruses in eastern Ontario, Canada

Medical and Veterinary Entomology, Volume 40, Issue 3, Page 634-646, September 2026.
Mosquitoes in Eastern Ontario, Canada, readily fed on bloodmeal hosts consistent with patterns observed in other regions of North America. Enzootic and bridge vector mosquitoes fed on amplification hosts like American Robins (Turdus migratorius) together with humans, highlighting a potential route for WNV and EEEV transmission to human populations. Our
Colton R. A. Stephens, Mark R. Forbes, Scott Wilson, Antoinette Ludwig, David R. Lapen, Greg W. Mitchell   +5 more
wiley   +1 more source

Schwere Frühsommermeningoencephalitis (FSME) sechs Jahre nach korrekter Impfung [PDF]

, 2009
A case of severe tick-borne encephalitis (TBE) 6 years after correct vaccination – could it have been prevented by a search for seroconversion after vaccination?
S Rüttimann, A Kind, Kind, A., Rüttimann, S.   +3 more
core   +1 more source