Results 51 to 60 of about 61,946 (270)

Viruses: Friends and Foes [PDF]

, 2018
In this chapter, we will review how viruses can be used to positively affect joints and cartilage of their hosts. Many viruses are arthrogenic, and cause persistent and debilitating arthritis.
Rudd, Penny, Lara J. Herrero, Herrero, Lara, Penny A. Rudd   +3 more
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Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Current status on encephalitic alphavirus vaccines development: Advances, challenges, and global health perspectives

Infectious Medicine
Alphaviruses are a globally distributed group of arboviruses responsible for two distinct disease manifestations, namely inflammatory polyarthritis and encephalitis. Among the arthritogenic viruses, chikungunya virus (CHIKV) is the most prevalent and has
Xiaojing Yang, Yuying Ning, Chengnan Xu, Qianqian Zhang, Yangchao Dong, Yuan Wang, Fanglin Zhang, Yingfeng Lei, Wei Ye   +8 more
doaj   +1 more source

Powassan Virus Infection Detected by Metagenomic Next-Generation Sequencing, Ohio, USA

Emerging Infectious Diseases, 2023
We describe a 4-year-old male patient in Ohio, USA, who had encephalitis caused by Powassan virus lineage 2. Virus was detected by using metagenomic next-generation sequencing and confirmed with IgM and plaque reduction neutralization assays. Clinicians
Marjorie Farrington, Jamie Elenz, Matthew Ginsberg, Charles Y. Chiu, Steve Miller, Scott F. Pangonis   +5 more
doaj   +1 more source

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

The Case of a 40‐Year‐Old Man With New‐Onset Status Epilepticus in the Setting of HIV Infection

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 40‐year‐old man from Andhra Pradesh in India, while on regular antiretroviral treatment (ART) for long‐standing HIV infection presented with a 1‐day history of new‐onset status epilepticus. CT and MRI brain showed multifocal cerebral ring lesions, some of which demonstrated characteristic ‘hole‐with‐a‐dot’ sign.
Vadde Akhil, Ramachandiran Nandhagopal
wiley   +1 more source

A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species [PDF]

, 2006
The V protein of the paramyxovirus Nipah virus (NiV) has been shown to antagonize the interferon (IFN) response in human cells via sequestration of STAT1 and STAT2.
Goodbourn, S, Steve Goodbourn, Stock, N, Wang, LF, Richard Randall, Kathrin Hagmaier, Hagmaier, K, Lin-Fa Wang, Randall, R, Randall, Richard Edward, Nicola Stock, Wang, L-F   +11 more
core   +1 more source

Japanese Encephalitis Virus Genotype Replacement, Taiwan, 2009–2010

Emerging Infectious Diseases, 2011
Genotype I of Japanese encephalitis virus first appeared in Taiwan in 2008. Phylogenetic analysis of 37 viruses from pig farms in 2009–2010 classified these viruses into 2 unique subclusters of genotype I viruses and suggested multiple introductions and ...
Yi-Ying Chen, Yi-Chin Fan, Wu-Chun Tu, Rey-Yi Chang, Chen-Chang Shih, In-Houng Lu, Maw-Shien Chien, Wei-Cheng Lee, Ter-Hsin Chen, Gwong-Jen Chang, Shyan-Song Chiou   +10 more
doaj   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Sequence analysis of the small (s) RNA segment of viruses in the genus Orthobunyavirus [PDF]

, 2007
Viruses in the genus Orthobunyavirus (family Bunyaviridae) are classified serologically into 18 serogroups. The viruses have a tripartite genome of negative sense RNA composed of large (L), medium (M) and small (S) segments.
Mohamed, Maizan
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