Results 191 to 200 of about 75,080 (214)

Experimental Autoimmune Encephalomyelitis in Marmosets

2014
Experimental autoimmune encephalomyelitis (EAE) in the common marmoset, a small-bodied Neotropical primate, is a well-known and validated animal model for multiple sclerosis (MS). This model can be used for exploratory research, i.e., investigating the pathogenic mechanisms involved in MS, and applied research, testing the efficacy of new potential ...
S Anwar, Jagessar, Karin, Dijkman, Jordon, Dunham, Bert A, 't Hart, Yolanda S, Kap   +4 more
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Experimental Autoimmune Encephalomyelitis in the Rat

Current Protocols in Immunology, 2009
AbstractThere are several diverse rat models of experimental autoimmune encephalomyelitis (EAE) that can be used to investigate the pathogenesis and regulation of autoimmunity against CNS myelin. The disease course of these models ranges from an acute monophasic disease with limited demyelination to a chronic relapsing or chronic progressive course ...
Mark, Mannie, Robert H, Swanborg, Jolie A, Stepaniak   +2 more
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Neuroendocrine Influences on Experimental Autoimmune Encephalomyelitis

Annals of the New York Academy of Sciences, 1998
Abstract: Experimental autoimmune encephalomyelitis (EAE), a model for human multiple sclerosis, is an inflammatory disease of the CNS mediated by autoreactive T lymphocytes directed against the neuroantigen, myelin basic protein (MBP). EAE is inducible in the Lewis rat, which exhibits an acute monophasic disease, and in selected mouse strains, which ...
C C, Whitacre, K, Dowdell, A C, Griffin
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Gene Therapy in Experimental Autoimmune Encephalomyelitis

Journal of Clinical Immunology, 2000
Gene therapy traditionally has been associated with "gene replacement." where exogenous recombinant DNA is introduced ex vivo into somatic cells that are then introduced back into the patient as a way to correct an inherited genetic defect. However, several novel gene therapy strategies for treating autoimmune diseases recently have emerged. Strategies
P M, Mathisen, V K, Tuohy
openaire   +2 more sources

Experimental Autoimmune Encephalomyelitis in the Rat

Current Protocols in Immunology, 1996
AbstractThis unit details the materials and methods required for both active induction and adoptive transfer of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse strain using intact proteins or peptides from the two major myelin proteins: proteolipid protein (PLP) and myelin basic protein (MBP).
Robert H, Swanborg, Jolie A, Stepaniak
openaire   +2 more sources

Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, 2019
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS.
Natalia S, Novikova, Anastasia S, Diatlova, Kristina Z, Derevtsova, Elena A, Korneva, Tamara V, Viktorovna, Yuri, Ostrinki, Lital, Abraham, Shir, Quinn, Yahel, Segal, Leonid P, Churilov, Miri, Blank, Yehuda, Shoenfeld, Rina, Aharoni, Howard, Amital   +13 more
openaire   +2 more sources

Experimental autoimmune encephalomyelitis

1995
Experimental Autoimmune Encephalomyelitis (EAE) is the prototype for cell-mediated autoimmune disease in general, and is the best animal model of human CNS inflammatory demyelinating disease. It has three forms, which vary in clinical course and neuropathology: acute EAE, hyperacute EAE and chronic relapsing EAE.
openaire   +1 more source

Behavioral aspects of experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, 2000
Acute inflammation is known to induce a depressive-like sickness behavior syndrome in humans and in experimental animals. In the present study, we sought to determine whether a chronic neuroautoimmune inflammation is also associated with a similar behavioral syndrome.
Y, Pollak, H, Ovadia, I, Goshen, R, Gurevich, K, Monsa, R, Avitsur, R, Yirmiya   +6 more
openaire   +2 more sources

Experimental Autoimmune Encephalomyelitis in the Mouse

Current Protocols in Immunology, 2010
AbstractThis unit details the materials and methods required for both active induction and adoptive transfer of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse strain using intact proteins or peptides from the two major myelin proteins: proteolipid protein (PLP) and myelin basic protein (MBP).
Stephen D, Miller, William J, Karpus, Todd Scott, Davidson   +2 more
openaire   +2 more sources

Experimental Murine Autoimmune Encephalomyelitis

1979
Experimental autoimmune (allergic) encephalomyelitis is an inflammatory and demyelinating disease of the central nervous system (CNS) mediated by the cellular component of the immune response. EAE is induced in laboratory animals when CNS tissue homogenates or myelin are injected together with oil adjuvants containing mycobacteria (Freund’s complete ...
D. S. Linthicum, I. R. Mackay, P. R. Carnegie   +2 more
openaire   +1 more source