Results 201 to 210 of about 49,920 (244)
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Experimental Autoimmune Encephalomyelitis in the Rat
Current Protocols in Immunology, 2009AbstractThere are several diverse rat models of experimental autoimmune encephalomyelitis (EAE) that can be used to investigate the pathogenesis and regulation of autoimmunity against CNS myelin. The disease course of these models ranges from an acute monophasic disease with limited demyelination to a chronic relapsing or chronic progressive course ...
Mark, Mannie +2 more
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Experimental Autoimmune Encephalomyelitis in the Rat
Current Protocols in Immunology, 1996AbstractThis unit details the materials and methods required for both active induction and adoptive transfer of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse strain using intact proteins or peptides from the two major myelin proteins: proteolipid protein (PLP) and myelin basic protein (MBP).
Robert H, Swanborg, Jolie A, Stepaniak
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Experimental Autoimmune Encephalomyelitis in the Mouse
Current Protocols in Immunology, 2010AbstractThis unit details the materials and methods required for both active induction and adoptive transfer of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse strain using intact proteins or peptides from the two major myelin proteins: proteolipid protein (PLP) and myelin basic protein (MBP).
Stephen D, Miller +2 more
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Genetics of Experimental Autoimmune Encephalomyelitis
1999The genetic basis for susceptibility to experimental autoimmune encepha- lomyelitis (EAE) has been the subject of intense study for several decades. In spite of this long history, however, the eVort has only yielded small hints and contradictory leads to which genes influence susceptibility to this autoimmune disease.
J A, Encinas, V K, Kuchroo
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Experimental Autoimmune Encephalomyelitis in Primates
2008Due to their genetic and immunological proximity to humans, the common marmoset, Callithrix jacchus, provides an important bridge between rodent-based research and the human disease. Experimental autoimmune encephalomyelitis (EAE) induced in the outbred common marmoset provides a highly reproducible model of multiple sclerosis (MS) phenotypically ...
Smith, Paul A. +2 more
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Experimental Autoimmune Encephalomyelitis in Marmosets
2014Experimental autoimmune encephalomyelitis (EAE) in the common marmoset, a small-bodied Neotropical primate, is a well-known and validated animal model for multiple sclerosis (MS). This model can be used for exploratory research, i.e., investigating the pathogenic mechanisms involved in MS, and applied research, testing the efficacy of new potential ...
S Anwar, Jagessar +4 more
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Inheritance of susceptibility to experimental autoimmune encephalomyelitis
Journal of Neuroscience Research, 1996Experimental autoimmune encephalomyelitis is a disease of the central nervous system that can be readily induced in a variety of species by immunization with myelin proteins. It is one of the most commonly studied models of cell-mediated autoimmune disease and consequently has been important in the elucidation of many immunological functions in vivo ...
J A, Encinas, H L, Weiner, V K, Kuchroo
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Experimental Autoimmune Encephalomyelitis
2003Much of our present understanding of the pathogenesis in multiple sclerosis (MS) and other disorders of the central nervous system (CNS) is based on information gained through studying experimental animal models. Whereas the investigation of human tissue samples—obtained by biopsies or postmortem—can provide only a focused view at one given time-point ...
Hans-Peter Hartung, Bernd C. Kieseier
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Neuroendocrine Influences on Experimental Autoimmune Encephalomyelitis
Annals of the New York Academy of Sciences, 1998Abstract: Experimental autoimmune encephalomyelitis (EAE), a model for human multiple sclerosis, is an inflammatory disease of the CNS mediated by autoreactive T lymphocytes directed against the neuroantigen, myelin basic protein (MBP). EAE is inducible in the Lewis rat, which exhibits an acute monophasic disease, and in selected mouse strains, which ...
C C, Whitacre, K, Dowdell, A C, Griffin
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Suppression of experimental autoimmune encephalomyelitis by sulfasalazine
Acta Neurologica Scandinavica, 2009It has recently been suggested that the sulfidopeptide leukotriene C4 (LTC4), a 5-lipoxygenase product of the arachidonic acid metabolism and one of the most potent mediators of vascular permeability, might be involved in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).
M, Prosiegel +5 more
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