Results 1 to 10 of about 929 (112)

Comprehensive Atlas of the Myelin Basic Protein Interaction Landscape

Biomolecules, 2021
Intrinsically disordered myelin basic protein (MBP) is one of the key autoantigens in autoimmune neurodegeneration and multiple sclerosis particularly.
Evgeniya V. Smirnova, Tatiana V. Rakitina, Rustam H. Ziganshin, Georgij P. Arapidi, George A. Saratov, Anna A. Kudriaeva, Alexey A. Belogurov   +6 more
doaj   +3 more sources

Regional analysis of myelin basic protein across postnatal brain development of C57BL/6J mice

Frontiers in Neuroanatomy
Healthy brain development hinges on proper myelination, with disruption contributing to a wide array of neurological disorders. Immunohistochemical analysis of myelin basic protein (MBP) is a fundamental technique for investigating myelination and ...
Siddhi S. Ozarkar, Siddhi S. Ozarkar, Ridthi K. R. Patel, Ridthi K. R. Patel, Tasmai Vulli, Tasmai Vulli, Carlee A. Friar, Carlee A. Friar, Alain C. Burette, Alain C. Burette, Benjamin D. Philpot, Benjamin D. Philpot, Benjamin D. Philpot   +12 more
doaj   +3 more sources

Making Myelin Basic Protein -from mRNA transport to localized translation

Frontiers in Cellular Neuroscience, 2013
In the central nervous system (CNS) of most vertebrates, oligodendrocytes enwrap neuronal axons with extensions of their plasma membrane to form the myelin sheath. Several proteins are characteristically found in myelin of which Myelin Basic Protein (MBP)
Christina eMüller, Nina Marita Bauer, Isabelle eSchäfer, Robin eWhite   +3 more
doaj   +3 more sources

Adhesion Process of Biomimetic Myelin Membranes Triggered by Myelin Basic Protein

Frontiers in Chemistry, 2021
The myelin sheath—a multi-double-bilayer membrane wrapped around axons—is an essential part of the nervous system which enables rapid signal conduction.
Benjamin Krugmann, Benjamin Krugmann, Alexandros Koutsioubas, Luman Haris, Luman Haris, Samantha Micciulla, Didier Lairez, Aurel Radulescu, Stephan Förster, Andreas M. Stadler, Andreas M. Stadler   +10 more
doaj   +1 more source

Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients [PDF]

PeerJ, 2023
The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have been actively studied recently, but the mechanism of the catalytic properties of immunoglobulin molecules remains unknown.
Maria Zavialova, Daria Kamaeva, Laura Kazieva, Vladlen S. Skvortsov, Liudmila Smirnova   +4 more
doaj   +2 more sources

Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork. [PDF]

PLoS Biology, 2013
Rapid conduction of nerve impulses requires coating of axons by myelin. To function as an electrical insulator, myelin is generated as a tightly packed, lipid-rich multilayered membrane sheath.
Shweta Aggarwal, Nicolas Snaidero, Gesa Pähler, Steffen Frey, Paula Sánchez, Markus Zweckstetter, Andreas Janshoff, Anja Schneider, Marie-Theres Weil, Iwan A T Schaap, Dirk Görlich, Mikael Simons   +11 more
doaj   +1 more source

Autoantigen microarrays reveal myelin basic protein autoantibodies in morphea

Journal of Translational Medicine, 2022
Background Morphea is an autoimmune, sclerosing skin disorder. Despite the recent emphasis on immune dysregulation in morphea, the role of autoantibodies in morphea pathogenesis or utility as biomarkers are poorly defined.
Jane L. Zhu, Ricardo T. Paniagua, Henry W. Chen, Stephanie Florez-Pollack, Elaine Kunzler, Noelle Teske, Yevgeniya Byekova Rainwater, Quan-Zhen Li, Gregory A. Hosler, Wenhao Li, Denise M. O. Ramirez, Nancy L. Monson, Heidi T. Jacobe   +12 more
doaj   +1 more source

Enzymic methylation of myelin basic protein in myelin [PDF]

Biochemical Journal, 1991
Myelin fractions with different degrees of compaction were isolated from bovine brain, and post-translational methylation of membrane-associated proteins was studied. When the purified myelin-basic-protein-specific protein methylase I and S-adenosyl-L-[methyl-14C]methionine were added exogenously, the most compact myelin fraction exhibited higher ...
S K, Ghosh, N, Rawal, S K, Syed, W K, Paik, S D, Kim   +4 more
openaire   +2 more sources

SncRNA715 Inhibits Schwann Cell Myelin Basic Protein Synthesis. [PDF]

PLoS ONE, 2015
Myelin basic proteins (MBP) are major constituents of the myelin sheath in the central nervous system (CNS) and the peripheral nervous system (PNS). In the CNS Mbp translation occurs locally at the axon-glial contact site in a neuronal activity-dependent
Christina Müller, Nina M Hochhaus, Xavier Fontana, Heiko J Luhmann, Robin White   +4 more
doaj   +1 more source

Proteome Profile of Myelin in the Zebrafish Brain

Frontiers in Cell and Developmental Biology, 2021
The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Sophie B. Siems, Olaf Jahn, Laura J. Hoodless, Ramona B. Jung, Dörte Hesse, Wiebke Möbius, Wiebke Möbius, Tim Czopka, Hauke B. Werner   +8 more
doaj   +1 more source