Identification of Myelin Basic Protein Proximity Interactome Using TurboID Labeling Proteomics [PDF]
Cells, 2023 Myelin basic protein (MBP) is one of the key structural elements of the myelin sheath and has autoantigenic properties in multiple sclerosis (MS).
Evgeniya V. Smirnova +6 more
doaj +4 more sources
Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients [PDF]
PeerJ, 2023 The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have been actively studied recently, but the mechanism of the catalytic properties of immunoglobulin molecules remains unknown.
Maria Zavialova +4 more
doaj +4 more sources
Structural homology of myelin basic protein and muscarinic acetylcholine receptor: Significance in the pathogenesis of complex regional pain syndrome [PDF]
Molecular Pain, 2018 Complex regional pain syndrome is an extremely painful condition that develops after trauma to a limb. Complex regional pain syndrome exhibits autoimmune features in part mediated by autoantibodies against muscarinic‐2 acetylcholine (M2) receptor.
Veronica I Shubayev +2 more
doaj +2 more sources
Autoantigen microarrays reveal myelin basic protein autoantibodies in morphea [PDF]
Journal of Translational Medicine, 2022 Background Morphea is an autoimmune, sclerosing skin disorder. Despite the recent emphasis on immune dysregulation in morphea, the role of autoantibodies in morphea pathogenesis or utility as biomarkers are poorly defined.
Jane L. Zhu +12 more
doaj +2 more sources
Comprehensive Atlas of the Myelin Basic Protein Interaction Landscape [PDF]
Biomolecules, 2021 Intrinsically disordered myelin basic protein (MBP) is one of the key autoantigens in autoimmune neurodegeneration and multiple sclerosis particularly.
Evgeniya V. Smirnova +6 more
doaj +2 more sources
Adhesion Process of Biomimetic Myelin Membranes Triggered by Myelin Basic Protein [PDF]
Frontiers in Chemistry, 2021 The myelin sheath—a multi-double-bilayer membrane wrapped around axons—is an essential part of the nervous system which enables rapid signal conduction.
Benjamin Krugmann +10 more
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Myelin Basic Protein Post-Translational Modifications Orchestrate Astrocyte Regulatory Networks [PDF]
NeuroSciMultiple sclerosis (MS) pathogenesis involves not only immune-mediated myelin injury but also glial responses. We examined how three charge isomers of myelin basic protein (MBP)—native (C1), phosphorylated (C4), and citrullinated (C8)—modulate rat ...
Jeremy Ramsden +4 more
doaj +2 more sources
Regional analysis of myelin basic protein across postnatal brain development of C57BL/6J mice [PDF]
Frontiers in NeuroanatomyHealthy brain development hinges on proper myelination, with disruption contributing to a wide array of neurological disorders. Immunohistochemical analysis of myelin basic protein (MBP) is a fundamental technique for investigating myelination and ...
Siddhi S. Ozarkar +12 more
doaj +2 more sources
Myelin Basic Protein and a Multiple Sclerosis-related MBP-peptide Bind to Oligonucleotides [PDF]
Molecular Therapy: Nucleic Acids, 2014 Aptamer ligands for myelin basic protein (MBP) were obtained using the systematic evolution of ligand by exponential enrichment (SELEX) method. Two clones were isolated from a pool of oligonucleotides and tested for MBP targeting.
Guido Tomás Rozenblum +2 more
doaj +2 more sources
Myelin Basic Protein and Cardiac Sympathetic Neurodegeneration in Nonhuman Primates [PDF]
Neurology Research International, 2021 Minimal myelination is proposed to be a contributing factor to the preferential nigral neuronal loss in Parkinson’s disease (PD). Similar to nigral dopaminergic neurons, sympathetic neurons innervating the heart have long, thin axons which are ...
Jeanette M. Metzger +8 more
doaj +2 more sources