Results 21 to 30 of about 1,028 (211)

Identification of Myelin Basic Protein Proximity Interactome Using TurboID Labeling Proteomics

Cells, 2023
Myelin basic protein (MBP) is one of the key structural elements of the myelin sheath and has autoantigenic properties in multiple sclerosis (MS).
Evgeniya V. Smirnova, Tatiana V. Rakitina, Rustam H. Ziganshin, George A. Saratov, Georgij P. Arapidi, Alexey A. Belogurov, Anna A. Kudriaeva   +6 more
doaj   +1 more source

Central and peripheral dysmyelination in a 3‐year‐old girl with ring chromosome 18

Clinical Case Reports, 2019
Myelin basic protein (MBP) contributes to peripheral and central nervous system myelin. Developmental myelinopathies exist on a clinical spectrum, but MBP is not included on leukodystrophy or CMT gene panels.
Dawn Brianna Lammert, David Miedema, Josiree Ochotorena, Nienke Dosa, Kalliopi Petropoulou, Roger Robert Lebel, Ai Sakonju   +6 more
doaj   +1 more source

CONTENTS OF SERUM MYELIN BASIC PROTEIN-IGG ANTIBODIES COMPLEXES IN NORMAL PREGNANCY AND GESTOSIS

Медицинская иммунология, 2014
Serum levels of myelin basic protein (MBP)-bound immune complexes were studied in blood sera from women with gestosis, as compared with those in normal pregnancy and non-pregnant woman.
V. G. Levchenko, N. V. Maltseva, O. F. Lykova, T. V. Konysheva, V. N. Zorina   +4 more
doaj   +1 more source

Endogenous interferon-β-inducible gene expression and interferon-β-treatment are associated with reduced T cell responses to myelin basic protein in multiple sclerosis.

PLoS ONE, 2015
Autoreactive CD4+ T-cells are considered to play a major role in the pathogenesis of multiple sclerosis. In experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, exogenous and endogenous type I interferons restrict disease ...
Lars Börnsen, Jeppe Romme Christensen, Rikke Ratzer, Chris Hedegaard, Helle B Søndergaard, Martin Krakauer, Dan Hesse, Claus H Nielsen, Per S Sorensen, Finn Sellebjerg   +9 more
doaj   +1 more source

Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils

Laboratory Animal Research, 2017
Myelin degeneration is one of the characteristics of aging and degenerative diseases. This study investigated age-related alterations in expression of myelin basic protein (MBP) in the hippocampal subregions (dentate gyrus, CA2/3 and CA1 areas) of ...
Ji Hyeon Ahn, Tae-Kyeong Lee, Joon Ha Park, Jeong Hwi Cho, In Hye Kim, Jae Chul Lee, Seongkweon Hong, Yong Hwan Jeon, Il Jun Kang, Young Joo Lee, Moo-Ho Won, Choong-Hyun Lee   +11 more
doaj   +1 more source

Oligodendrocytes in HIV-associated pain pathogenesis

Molecular Pain, 2016
Background Although the contributions of microglia and astrocytes to chronic pain pathogenesis have been a focal point of investigation in recent years, the potential role of oligodendrocytes, another major type of glial cells in the CNS that generates ...
Yuqiang Shi PhD, Jianhong Shu PhD, Zongsuo Liang PhD, Subo Yuan MD, PhD, Shao-Jun Tang PhD   +4 more
doaj   +1 more source

How Does Protein Zero Assemble Compact Myelin?

Cells, 2020
Myelin protein zero (P0), a type I transmembrane protein, is the most abundant protein in peripheral nervous system (PNS) myelin—the lipid-rich, periodic structure of membrane pairs that concentrically encloses long axonal segments.
Arne Raasakka, Petri Kursula
doaj   +1 more source

Autophagic degradation of CNS myelin maintains axon integrity

Cell Stress, 2022
(Macro)autophagy is a major lysosome-dependent degradation mechanism which engulfs, removes and recycles unwanted cytoplasmic material, including damaged organelles and toxic protein aggregates.
Niki Ktena, Stefanos Ioannis Kaplanis, Irina Kolotuev, Alexandros Georgilis, Emmanouela Kallergi, Vasiliki Stavroulaki, Vassiliki Nikoletopoulou, Maria Savvaki, Domna Karagogeos   +8 more
doaj   +1 more source

Lethal adulthood myelin breakdown by oligodendrocyte-specific Ddx54 knockout

iScience, 2023
Summary: Multiple sclerosis (MS) is a leading disease that causes disability in young adults. We have previously shown that a DEAD-box RNA helicase Ddx54 binds to mRNA and protein isoforms of myelin basic protein (MBP) and that Ddx54 siRNA blocking ...
Hiroaki Oizumi, Yuki Miyamoto, Chika Seiwa, Masahiro Yamamoto, Nozomu Yoshioka, Seiichi Iizuka, Tomohiro Torii, Katsuya Ohbuchi, Kazushige Mizoguchi, Junji Yamauchi, Hiroaki Asou   +10 more
doaj   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source