Results 11 to 20 of about 51,525 (291)

Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker [PDF]

Basic and Clinical Neuroscience, 2021
Introduction: Multiple Sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As Myelin Basic Protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP
Mohammad Hossein Mirzaii-Dizgah, Mohammad Reza Mirzaii-Dizgah, Iraj Mirzaii-Dizgah   +2 more
doaj   +2 more sources

Myelin basic protein enhances axonal regeneration from neural progenitor cells [PDF]

Cell & Bioscience, 2021
Introduction Stem cell therapy using neural progenitor cells (NPCs) shows promise in mitigating the debilitating effects of spinal cord injury (SCI). Notably, myelin stimulates axonal regeneration from mammalian NPCs.
Zhengjian Yan, Lei Chu, Xiaojiong Jia, Lu Lin, Si Cheng   +4 more
doaj   +2 more sources

Amyloid fibrils of the myelin basic protein are an integral component of myelin in the vertebrate brain [PDF]

Scientific Reports
The myelin basic protein (MBP) is the most abundant intracellular protein of the myelin, which forms the electrically insulating sheath of axons of many actively functioning neurons. This protein binds the opposite membranes of the flattened processes of
Evgeniy I. Sysoev, Aleksandr A. Shenfeld, Tatyana A. Belashova, Anna A. Valina, Sergey P. Zadorsky, Alexey P. Galkin   +5 more
doaj   +2 more sources

Phase-Dependent Adsorption of Myelin Basic Protein to Phosphatidylcholine Lipid Bilayers [PDF]

Membranes
The dense packing of opposite cytoplasmic surfaces of the lipid-enriched myelin membrane, responsible for the proper saltatory conduction of nerve impulses through axons, is ensured by the adhesive properties of myelin basic protein (MBP).
Petra Maleš, Zlatko Brkljača, Ivo Crnolatac, Dražen Petrov, Danijela Bakarić   +4 more
doaj   +2 more sources

Myelin basic protein charge isomers change macrophage polarization

Journal of Inflammation Research, 2019
Elene Tsitsilashvili,1 Maia Sepashvili,1,2 Marika Chikviladze,1 Lali Shanshiashvili,1,2,* David Mikeladze1,2,* 1Institute of Chemical Biology, Ilia State University, Tbilisi, Georgia; 2Department of Biochemistry, I.
Tsitsilashvili E, Sepashvili M, Chikviladze M, Shanshiashvili L, Mikeladze D   +4 more
doaj   +1 more source

Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line [PDF]

Scientific Reports, 2017
Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm compartment between two cytoplasmic leaflets of stacked myelin membranes ...
Arne Raasakka, Salla Ruskamo, Julia Kowal, Robert Barker, Anne Baumann, Anne Martel, Jussi Tuusa, Matti Myllykoski, Jochen Bürck, Anne S. Ulrich, Henning Stahlberg, Petri Kursula   +11 more
doaj   +2 more sources

Myelin basic protein and occludin may be the biomarkers to diagnose leukoaraiosis and cognitive dysfunction [PDF]

Scientific Reports
Leukoaraiosis (LA) can lead to a range of clinical symptoms, with cognitive dysfunction being the most prominent. However, the biomarkers that could assist in the early diagnosis of LA and predict disease progression are lacking.
Yingping Chen, Hua Li, Junliang Lin, Huanjian Huang, Yingying Cao, Hong Zhou   +5 more
doaj   +2 more sources

Citrullinated isomer of myelin basic protein can induce inflammatory responses in astrocytes [PDF]

IBRO Neuroscience Reports
Purpose: During the course of demyelinating inflammatory diseases, myelin-derived proteins, including myelin basic protein(MBP), are secreted into extracellular space.
Marika Chikviladze, Nino Mamulashvili, Maia Sepashvili, Nana Narmania, Jeremy Ramsden, Lali Shanshiashvili, David Mikeladze   +6 more
doaj   +2 more sources

Nanoformulated Recombinant Human Myelin Basic Protein and Rituximab Modulate Neuronal Perturbations in Experimental Autoimmune Encephalomyelitis in Mice [PDF]

International Journal of Nanomedicine, 2022
Muhammed A Saad,1,2 Noha M Eissa,2 Mohammed A Ahmed,3 Aliaa N ElMeshad,3,4 Götz Laible,5– 7 Ahmed S Attia,8 Medhat A Al-Ghobashy,9,10 Rania M Abdelsalam,1,2 Muhammad Y Al-Shorbagy1,11 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo
Saad MA, Eissa NM, Ahmed MA, ElMeshad AN, Laible G, Attia AS, Al-Ghobashy MA, Abdelsalam RM, Al-Shorbagy MY   +8 more
doaj   +2 more sources

D-Aspartic acid in purified myelin and myelin basic protein

Biochemical and Biophysical Research Communications, 1986
The presence of the biologically uncommon D-isomer of aspartic acid in the white matter of human brains has been reported previously from this laboratory (1). We now report that the level of D-aspartate in human brains is higher in purified myelin than in white matter and is even higher in the myelin basic protein fraction.
G H, Fisher, N M, Garcia, I L, Payan, R, Cadilla-Perezrios, W A, Sheremata, E H, Man   +5 more
openaire   +3 more sources