Results 11 to 20 of about 1,028 (211)
Overview of myelin, major myelin lipids, and myelin-associated proteins
Frontiers in Chemistry, 2023 Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains the main characteristics of biological membranes, such as lipid bilayer, but differs from them in several important respects.
Alexander Kister, Ilya Kister
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Journal of Genetic Engineering and Biotechnology, 2022 Background Myelin basic protein (MBP) is one of the most important structural components of the myelin sheaths in both central and peripheral nervous systems. MBP has several functions including organization of the myelin membranes, reorganization of the
Juan Sebastian Cruz-Méndez +3 more
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Molecular Pain, 2018 Complex regional pain syndrome is an extremely painful condition that develops after trauma to a limb. Complex regional pain syndrome exhibits autoimmune features in part mediated by autoantibodies against muscarinic‐2 acetylcholine (M2) receptor.
Veronica I Shubayev +2 more
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Phosphorylation of Myelin Basic Protein
Journal of Biological Chemistry, 1974 Myelin membranes prepared from rat brain possess both the enzyme and substrates to incorporate 32P from [γ-32P]ATP into membrane protein constituents. Of the myelin polypeptides, only the two basic proteins were phosphorylated; and both components appeared to be equally good substrates for endogenous or added protein kinases.
A J, Steck, S H, Appel
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Chronic Stress, 2018 Background Astrocytes and oligodendrocytes are pathologically altered in dorsolateral prefrontal and orbitofrontal cortices in major depressive disorder.
José Javier Miguel-Hidalgo +3 more
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Myelin basic protein enhances axonal regeneration from neural progenitor cells
Cell & Bioscience, 2021 Introduction Stem cell therapy using neural progenitor cells (NPCs) shows promise in mitigating the debilitating effects of spinal cord injury (SCI). Notably, myelin stimulates axonal regeneration from mammalian NPCs.
Zhengjian Yan +4 more
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Myelin Basic Protein and Cardiac Sympathetic Neurodegeneration in Nonhuman Primates
Neurology Research International, 2021 Minimal myelination is proposed to be a contributing factor to the preferential nigral neuronal loss in Parkinson’s disease (PD). Similar to nigral dopaminergic neurons, sympathetic neurons innervating the heart have long, thin axons which are ...
Jeanette M. Metzger +8 more
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Lipid and basic protein interaction in myelin [PDF]
Biochemical Journal, 1974 1. Purified myelin labelled with [3H]myo-inositol or [1-14C]acetate was incubated with trypsin or acetylated trypsin at 37°C, pH8.0 for 30min. 2. After incubation and centrifugation analysis of the myelin pellet showed marked digestion of basic protein on polyacrylamide-gel electrophoresis. Proteolipid and Wolfgram proteins remained unchanged. 3.
N L, Banik, A N, Davison
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Molecular Pain, 2017 Background Calpain is a calcium-dependent cysteine protease, and inhibition of calpain by pre-treatment with MDL28170 attenuated the rat mechanical allodynia in a variety of pain models. Postherpetic neuralgia (Shingles) is a neuropathic pain conditioned
Xiao-Cui Yuan +12 more
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Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases
Cell Reports, 2016 Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to target myelin ...
Marie-Theres Weil +13 more
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