Results 41 to 50 of about 51,525 (291)

Oligodendrocytes in HIV-associated pain pathogenesis

Molecular Pain, 2016
Background Although the contributions of microglia and astrocytes to chronic pain pathogenesis have been a focal point of investigation in recent years, the potential role of oligodendrocytes, another major type of glial cells in the CNS that generates ...
Yuqiang Shi PhD, Jianhong Shu PhD, Zongsuo Liang PhD, Subo Yuan MD, PhD, Shao-Jun Tang PhD   +4 more
doaj   +1 more source

Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils

Laboratory Animal Research, 2017
Myelin degeneration is one of the characteristics of aging and degenerative diseases. This study investigated age-related alterations in expression of myelin basic protein (MBP) in the hippocampal subregions (dentate gyrus, CA2/3 and CA1 areas) of ...
Ji Hyeon Ahn, Tae-Kyeong Lee, Joon Ha Park, Jeong Hwi Cho, In Hye Kim, Jae Chul Lee, Seongkweon Hong, Yong Hwan Jeon, Il Jun Kang, Young Joo Lee, Moo-Ho Won, Choong-Hyun Lee   +11 more
doaj   +1 more source

Autophagic degradation of CNS myelin maintains axon integrity

Cell Stress, 2022
(Macro)autophagy is a major lysosome-dependent degradation mechanism which engulfs, removes and recycles unwanted cytoplasmic material, including damaged organelles and toxic protein aggregates.
Niki Ktena, Stefanos Ioannis Kaplanis, Irina Kolotuev, Alexandros Georgilis, Emmanouela Kallergi, Vasiliki Stavroulaki, Vassiliki Nikoletopoulou, Maria Savvaki, Domna Karagogeos   +8 more
doaj   +1 more source

Endogenous interferon-β-inducible gene expression and interferon-β-treatment are associated with reduced T cell responses to myelin basic protein in multiple sclerosis.

PLoS ONE, 2015
Autoreactive CD4+ T-cells are considered to play a major role in the pathogenesis of multiple sclerosis. In experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, exogenous and endogenous type I interferons restrict disease ...
Lars Börnsen, Jeppe Romme Christensen, Rikke Ratzer, Chris Hedegaard, Helle B Søndergaard, Martin Krakauer, Dan Hesse, Claus H Nielsen, Per S Sorensen, Finn Sellebjerg   +9 more
doaj   +1 more source

Lethal adulthood myelin breakdown by oligodendrocyte-specific Ddx54 knockout

iScience, 2023
Summary: Multiple sclerosis (MS) is a leading disease that causes disability in young adults. We have previously shown that a DEAD-box RNA helicase Ddx54 binds to mRNA and protein isoforms of myelin basic protein (MBP) and that Ddx54 siRNA blocking ...
Hiroaki Oizumi, Yuki Miyamoto, Chika Seiwa, Masahiro Yamamoto, Nozomu Yoshioka, Seiichi Iizuka, Tomohiro Torii, Katsuya Ohbuchi, Kazushige Mizoguchi, Junji Yamauchi, Hiroaki Asou   +10 more
doaj   +1 more source

A Nanoscale Model System for the Human Myelin Sheath

, 2021
Here, we for the first time establish nanodiscs with the challenging lipid composition of myelin of the peripheral or central nervous systems, respectively (PNS and CNS, both containing >40% cholesterol, which so far has been thought to be detrimental ...
David, Haselberger, Carla, Schmidt, Tommy, Hofmann, Annette, Meister, Panagiotis L., Kastritis, Lisa, Müller, Kevin, Janson, Carolyn, Vargas, Matthias, Hoffmann, Sandro, Keller, Dariush, Hinderberger, manabendra, das   +11 more
core   +1 more source

How Does Protein Zero Assemble Compact Myelin?

Cells, 2020
Myelin protein zero (P0), a type I transmembrane protein, is the most abundant protein in peripheral nervous system (PNS) myelin—the lipid-rich, periodic structure of membrane pairs that concentrically encloses long axonal segments.
Arne Raasakka, Petri Kursula
doaj   +1 more source

Myelin basic protein peptide 45–89 induces the release of nitric oxide from microglial cells. [PDF]

, 2002
Continuous (24 h) exposure of mixed oligodendrocyte/microglial cells to peptides 45–89 derived from citrullinated C8 isoforms of myelin basic protein (MBP) induces cell death.
Pichkhadze, B., Machaidze, G., Mikeladze, D., Shanshiashvili, L., Ramsden, Jeremy J.   +4 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source