Results 61 to 70 of about 5,959 (257)
Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES
Advanced Science, EarlyView.In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu +5 more
wiley +1 more source
Immunodominant fragments of myelin basic protein initiate T cell-dependent pain
Journal of Neuroinflammation, 2012 Background The myelin sheath provides electrical insulation of mechanosensory Aβ-afferent fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath.
Liu Huaqing +9 more
doaj +1 more source
Advanced Science, EarlyView.Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li +13 more
wiley +1 more source
Effect of Sox10 on remyelination of the hippocampus in cuprizone‐induced demyelinated mice
Brain and Behavior, 2020 Objective The low number of oligodendrocytes (OLs) in the hippocampus of patients with schizophrenia suggests that hippocampal demyelination is changed in this condition. Sox10 is expressed throughout OL development.
Yu Shao +7 more
doaj +1 more source
Devic mouse: a spontaneous double-transgenic mouse model of human opticospinal multiple sclerosis and autoimmune T- B cell cooperation [PDF]
, 2007 Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS). Myelin antigen(s) specific T cells, B cells, and antibodies are thought to play a role in the pathogenesis of MS.
Krishnamoorthy, Gurumoorthy
core
, 1999 Myelin-associated oligodendrocytic basic protein (MOBP) and myelin basic protein (MBP) share many structural similarities. MOBP is synthesised by mature oligodendrocytes and localised at the major dense line (MDL), suggesting a role in the myelin ...
Davies, R.Wayne +7 more
core +1 more source
Endogenous phosphorylation of basic protein in myelin of varying degrees of compaction [PDF]
, 1988 Fractions containing myelin of varying degrees of compaction were prepared from human white matter. Protein kinase activity in these fractions was measured by using both endogenous and exogenous myelin basic protein (MBP) as substrates.
Schulz, Patricia +2 more
core +1 more source
Advanced Science, EarlyView.A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu +8 more
wiley +1 more source
Advanced Science, EarlyView.This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun +14 more
wiley +1 more source
Analysis of Myelin Basic Protein Fragmentation by Proteasome [PDF]
Acta Naturae, 2009 The proteasome is a high molecular protein complex whose purpose is specific protein degradation in eukaryotic cells. One of the proteasome functions is to produce peptides, which will then be presented on the outer cell membrane using main histocompatibility complex (MHC) molecules of the first or second class.
Bacheva, A. +6 more
openaire +3 more sources