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Transcriptional Fingerprint of Hypomyelination in and () Mice
ASN Neuro, 2016 The transcriptional program that controls oligodendrocyte maturation and central nervous system (CNS) myelination has not been fully characterized. In this study, we use high-throughput RNA sequencing to analyze how the loss of a key transcription factor,
Joshua D. Aaker +6 more
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Morphological study of Schwann cells remyelination in contused spinal cord of rats
Chinese Journal of Traumatology, 2013 【Abstract】Objective: To study the role and effect of Schwann cells (SCs) remyelination in contused spinal cord. Methods: Green fluorescence protein expressing-SCs were transplanted into the epicenter, rostral and caudal tis-sues of the injury ...
LI Yue +5 more
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Scientific ReportsLeukoaraiosis (LA) can lead to a range of clinical symptoms, with cognitive dysfunction being the most prominent. However, the biomarkers that could assist in the early diagnosis of LA and predict disease progression are lacking.
Yingping Chen +5 more
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Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2019 Introduction: Multiple sclerosis (MS) is a common neurodegenerative disease leading to the movement disorder and destruction of myelin. Physical exercise delays the onset of neurodegenerative processes by preventing the destruction of myelin and ...
Maryam Naghibzadeh +3 more
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A Rapid Method for Purification of Myelin Basic Protein
Journal of Neurochemistry, 1986Abstract: A rapid procedure for purification of myelin basic protein has been developed. White matter is delipidated with 2‐butanol, and the residue is extracted at pH 7.5 and 8.5. Myelin basic protein is solubilized by extraction in acetate buffer, pH 4.5.
Tiziana Bellini +2 more
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Myelin basic protein interacts with the myelin-specific ganglioside GM4
Brain Research, 1981Demyelinated plaques in multiple sclerosis have decreased amounts of both myelin basic protein and sialosylgalactosylceramide (GM4), a ganglioside specifically localized in myelin and oligodendroglia of the central nervous system. We have found that myelin basic protein is capable of releasing large quantities of entrapped [14C]glucose from ...
J D Reid
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Myelin breakdown and basic protein
Experimental Neurology, 1974Abstract The purpose of the present work was to study the mechanisms of myelin breakdown in experimental conditions and the fate of protein components in myelin, especially that of myelin basic protein which is known to be important in demyelinative disorders. The results showed that when myelin was incubated alone without any added enzymes there was
M, Röyttä +4 more
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Autoimmunity to Myelin Basic Protein
1982Experimental allergic encephalomyelitis (EAE) is an autoimmune central nervous system (CNS) disease which has been studied extensively, and has provided insight into mechanisms of immune tissue damage and immunologic self-tolerance. In addition, EAE serves as a prototype for human demyelinating diseases such as multiple sclerosis1.
R H, Swanborg, J H, Holda, J A, Killen
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Scandinavian Journal of Immunology, 1982
Our attention was first directed to a study of myelin proteins because of our interest in the induction of experimental allergic encephalomyelitis (EAE) and the fact that Kabat et al. (11) and Morgan (26) had reported that white matter was more encephalitogenic than gray matter.
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Our attention was first directed to a study of myelin proteins because of our interest in the induction of experimental allergic encephalomyelitis (EAE) and the fact that Kabat et al. (11) and Morgan (26) had reported that white matter was more encephalitogenic than gray matter.
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