Results 41 to 50 of about 114,193 (236)

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Novel Picornavirus in Lambs with Severe Encephalomyelitis

Emerging Infectious Diseases, 2019
Using metagenomic analysis, we identified a novel picornavirus in young preweaned lambs with neurologic signs associated with severe nonsuppurative encephalitis and sensory ganglionitis in 2016 and 2017 in the United Kingdom.
Leonie F. Forth, Sandra F.E. Scholes, Patricia A. Pesavento, Kenneth Jackson, Adrienne Mackintosh, Amanda Carson, Fiona Howie, Kore Schlottau, Kerstin Wernike, Anne Pohlmann, Dirk Höper, Martin Beer   +11 more
doaj   +1 more source

Magnetic resonance imaging in five patients with a tumefactive demyelinating lesion in the central nervous system [PDF]

Arquivos de Neuro-Psiquiatria, 1999
Five patients with a tumefactive lesion were clinically followed from 1992 to 1993. Four patients were female; age ranged from 32 to 57 years, the duration of symptoms varied from 3 days to 3 years.
HELGA C. ALMEIDA SILVA, DAGOBERTO CALLEGARO, PAULO E. MARCHIORI, MILBERTO SCAFF, ANA MARIA C. TSANACLIS   +4 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Clinical features and outcome of acute disseminated encephalomyelitis (ADEM): An outlook from South India

Annals of Indian Academy of Neurology, 2006
Introduction: Acute disseminated encephalomyelitis (ADEM) is an uncommon inflammatory demyelinating encephalomyelitis that may follow infections, vaccinations or occur spontaneously.
Maramattom Boby, Sarada C
doaj  

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Post Flu Shot Confusion – think ADEM!

Southwest Respiratory and Critical Care Chronicles, 2015
A 57-year-old Caucasian man with hypertension and diabetes presented with left arm weakness and headache for one day. He had an influenza vaccination 10 days prior to presentation.
Nanjunda Murthy Jyoti Prabha, Sanket R Thakore, Akram Zaqooq   +2 more
doaj  

Recurrent myelin oligodendrocyte glycoprotein⁃IgG⁃associated optic neuritis⁃encephalomyelitis: one case report

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
DOI:10.3969/j.issn.1672⁃6731.2020.10 ...
Jing SHA, Aishanjiang Yusufujiang, Mayinuer Maimaiti, Hong⁃yan LI   +3 more
doaj  

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Enterovirus A71 Infection and Neurologic Disease, Madrid, Spain, 2016

Emerging Infectious Diseases, 2019
We conducted an observational study from January 2016 through January 2017 of patients admitted to a reference pediatric hospital in Madrid, Spain, for neurologic symptoms and enterovirus infection.
Carmen Niño Taravilla, Isabel Pérez-Sebastián, Alberto García Salido, Claudia Varela Serrano, Verónica Cantarín Extremera, Anna Duat Rodríguez, Laura López Marín, Mercedes Alonso Sanz, Olga María Suárez Traba, Ana Serrano González   +9 more
doaj   +1 more source