Results 1 to 10 of about 6,319 (105)

The Underlying Mechanism of Modulation of Transient Receptor Potential Melastatin 3 by protons [PDF]

Frontiers in Pharmacology, 2021
Transient receptor potential melastatin 3 channel (TRPM3) is a calcium-permeable nonselective cation channel that plays an important role in modulating glucose homeostasis in the pancreatic beta cells.
Md Zubayer Hossain Saad, Md Zubayer Hossain Saad, Liuruimin Xiang, Liuruimin Xiang, Liuruimin Xiang, Yan-Shin Liao, Leah R. Reznikov, Jianyang Du, Jianyang Du   +8 more
doaj   +2 more sources

Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients [PDF]

Molecular Medicine, 2022
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystemic condition associated with post-infectious onset, impaired natural killer (NK) cell cytotoxicity and impaired ion channel function, namely Transient Receptor ...
Etianne Martini Sasso, Katsuhiko Muraki, Natalie Eaton-Fitch, Peter Smith, Olivia Ly Lesslar, Gary Deed, Sonya Marshall-Gradisnik   +6 more
doaj   +2 more sources

Identification of transient receptor potential melastatin 3 proteotypic peptides employing an efficient membrane protein extraction method for natural killer cells [PDF]

Frontiers in Physiology, 2022
Introduction: Mutations and misfolding of membrane proteins are associated with various disorders, hence they make suitable targets in proteomic studies.
Chandi T. Magawa, Chandi T. Magawa, Natalie Eaton-Fitch, Natalie Eaton-Fitch, Cassandra Balinas, Cassandra Balinas, Etianne Martini Sasso, Etianne Martini Sasso, Etianne Martini Sasso, Kiran Thapaliya, Kiran Thapaliya, Leighton Barnden, Leighton Barnden, Rebekah Maksoud, Rebekah Maksoud, Rebekah Maksoud, Breanna Weigel, Breanna Weigel, Breanna Weigel, Penny A. Rudd, Lara J. Herrero, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik   +22 more
doaj   +2 more sources

Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits [PDF]

eLife, 2017
Transient receptor potential melastatin 3 (TRPM3) channels are activated by heat, and chemical ligands such as pregnenolone sulphate (PregS) and CIM0216.
Doreen Badheka, Yevgen Yudin, Istvan Borbiro, Cassandra M Hartle, Aysenur Yazici, Tooraj Mirshahi, Tibor Rohacs   +6 more
doaj   +2 more sources

Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment [PDF]

Frontiers in Immunology, 2021
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating multi-systemic chronic condition of unknown aetiology classified as an immune dysfunction syndrome and neurological disorder.
Helene Cabanas, Helene Cabanas, Katsuhiko Muraki, Katsuhiko Muraki, Natalie Eaton-Fitch, Natalie Eaton-Fitch, Donald Ross Staines, Donald Ross Staines, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik   +9 more
doaj   +2 more sources

Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants [PDF]

PLoS ONE
Gulf War Illness (GWI) is a chronic condition characterized by multisystem symptoms that still affect up to one-third of veterans who engaged in combat in the Gulf War three decades ago.
Sonya Marshall-Gradisnik, Etianne Martini Sasso, Natalie Eaton-Fitch, Peter Smith, James N. Baraniuk, Katsuhiko Muraki   +5 more
doaj   +4 more sources

Transient Receptor Potential Melastatin-3 (TRPM3) Mediates Nociceptive-Like Responses in Hydra vulgaris. [PDF]

PLoS ONE, 2016
The ability of mammals to feel noxious stimuli lies in a heterogeneous group of primary somatosensory neurons termed nociceptors, which express specific membrane receptors, such as the Transient Receptor Potential (TRP) family.
Valentina Malafoglia, Lorenzo Traversetti, Floriano Del Grosso, Massimiliano Scalici, Filomena Lauro, Valeria Russo, Tiziana Persichini, Daniela Salvemini, Vincenzo Mollace, Massimo Fini, William Raffaeli, Carolina Muscoli, Marco Colasanti   +12 more
doaj   +2 more sources

Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients [PDF]

Molecular Medicine, 2018
Background Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME) is a debilitating disorder that is accompanied by reduced cytotoxic activity in natural killer (NK) cells. NK cells are an essential innate immune cell, responsible for recognising
Hélène Cabanas, Katsuhiko Muraki, Natalie Eaton, Cassandra Balinas, Donald Staines, Sonya Marshall-Gradisnik   +5 more
doaj   +2 more sources

Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients [PDF]

Frontiers in Immunology, 2019
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a seriously long-term and debilitating illness of unknown cause hallmarked by chronic pain and fatigue, memory and concentration impairment, and inflammation.
Helene Cabanas, Helene Cabanas, Helene Cabanas, Katsuhiko Muraki, Katsuhiko Muraki, Donald Staines, Donald Staines, Donald Staines, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik   +10 more
doaj   +2 more sources

Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients [PDF]

Molecular Medicine, 2019
Background Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a complex multifactorial disorder of unknown cause having multi-system manifestations.
H. Cabanas, K. Muraki, C. Balinas, N. Eaton-Fitch, D. Staines, S. Marshall-Gradisnik   +5 more
doaj   +2 more sources