Results 1 to 10 of about 6,833 (180)
Cold Temperature Encoding by Cutaneous TRPA1 and TRPM8-Carrying Fibers in the Mouse
Frontiers in Molecular Neuroscience, 2017 Previous research identified TRPM8 and TRPA1 cold transducers with separate functions, one being functional in the non-noxious range and the second one being a nociceptive transducer.
Zoltan Winter +4 more
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Physiological Reports, 2023 TRPM8 agonist has been reported to promote osteogenic differentiation of mesenchymal stem cells (MSCs), therefore we evaluated whether cooling‐induced activation of TRPM8 promotes myogenic differentiation of MSCs.
Ryo Takagi +5 more
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Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling
Molecular Brain, 2020 Postoperative shivering and cold hypersensitivity are major side effects of acute and chronic opioid treatments respectively. TRPM8 is a cold and menthol-sensitive channel found in a subset of dorsal root ganglion (DRG) nociceptors.
Mircea Iftinca +9 more
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Expression of temperature-sensitive ion channel TRPM8 in sperm cells correlates with vertebrate evolution [PDF]
PeerJ, 2015 Transient Receptor Potential cation channel, subfamily Melastatin, member 8 (TRPM8) is involved in detection of cold temperature, different noxious compounds and in execution of thermo- as well as chemo-sensitive responses at cellular levels.
Rakesh Kumar Majhi +10 more
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Two isoforms of Trpm8 in rat vas deferens
Біологічні студії, 2019 Trpm8 is a nonselective Ca2+-permeable ion channel activated by temperatures below 28 °C and cooling chemical compounds such as menthol and icilin. Trpm8 is expressed in sensory neurons where it functions for temperature detection. However, Trpm8 is also
K. Gulak, A. Kondratskyi
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Sensory discrimination between innocuous and noxious cold by TRPM8-expressing DRG neurons of rats
Molecular Pain, 2012 The TRPM8 channel is a principal cold transducer that is expressed on some primary afferents of the somatic and cranial sensory systems. However, it is uncertain whether TRPM8-expressing afferent neurons have the ability to convey innocuous and noxious ...
Sarria Ignacio +3 more
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PLoS ONE, 2021 Trpm8 (transient receptor potential cation channel, subfamily M, member 8) is expressed by sensory neurons and is involved in the detection of environmental cold temperatures.
Adriana Lelis Carvalho +7 more
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Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol
Journal of Neuroinflammation, 2022 Background No reports exist as to neuroprotective effects associated with topical activation of transient receptor potential melastatin 8 (TRPM8), a noted cold receptor.
Shiang-Suo Huang +9 more
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Wildlife Letters, 2023 Temperature influences all biological processes. In wild animals, the evolution of molecular thermosensors is crucial in ambient temperature adaption and habitat selection with species specificity.
Xiancui Lu +6 more
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Frontiers in Pharmacology, 2021 Epilepsy is a relatively common condition, but more than 30% of patients have refractory epilepsy that is inadequately controlled by or is resistant to multiple drug treatments.
Hiroshi Moriyama +10 more
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