Results 11 to 20 of about 6,833 (180)
Cell Reports, 2019 Summary: Activation of Gαq-coupled receptors by inflammatory mediators inhibits cold-sensing TRPM8 channels, aggravating pain and inflammation. Both Gαq and the downstream hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) inhibit TRPM8. Here, I
Xuming Zhang
exaly +3 more sources
Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians [PDF]
FEBS Open BioSensing environmental temperature is a complex process involving an array of channels expressed by nociceptive sensory neurons but is critical to allow animals to move away from suboptimal environments and find environments with ideal temperatures ...
Tadahiro Sawao +3 more
doaj +2 more sources
Cells, 2014 The transient receptor potential melastatin-subfamily member 8 (TRPM8) channels control Ca2+ homeostasis. Recent studies indicate that TRPM8 channels are aberrantly expressed and required for cellular proliferation in pancreatic adenocarcinoma.
Zhaohai Yang, Arthur Berg
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HPLC Purification of TRPM8 and Experimental Confirmation of Its Cholesterol Affinity on Synthetic Lipid Raft-like Models [PDF]
LifeThis study presents the successful expression, purification, and functional characterization of the human TRPM8 ion channel, a key player in temperature sensing and pain modulation.
Clotilde Beatrice Angelucci +6 more
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Structures of a mammalian TRPM8 in closed state
Nature Communications, 2022 The mechanism of cold-activated TRPM8 channel activation remains unclear. Here, authors have determined structures of mouse TRPM8 in apo or ligand-bound states, providing insights into the activation of TRPM8 structures in different states.
Cheng Zhao +7 more
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Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice
Molecular Metabolism, 2023 Objective: Mice with global deletion of the transient receptor potential channel melastatin family member 8 (TRPM8) are obese, and treatment of diet-induced obese (DIO) mice with TRPM8 agonists decrease body weight.
D. Liskiewicz +14 more
doaj +1 more source
Cell Death and Disease, 2022 Transient receptor potential melastatin 8 (TRPM8) functions as a Ca2+-permeable channel in the plasma membrane (PM). Dysfunction of TRPM8 is associated with human pancreatic cancer and several other diseases in clinical patients, but the underlying ...
Yuan Huang +15 more
doaj +1 more source
Headache: The Journal of Head and Face Pain, 2016 Migraine is among the most common diseases on earth and one of the most disabling, the latter due in large part to poor treatment efficacy. Development of new therapeutics is dependent on the identification of mechanisms contributing to migraine and discovery of targets for new drugs.
Greg, Dussor, Yu-Qing, Cao
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Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling. [PDF]
PLoS ONE, 2011 We have shown that cutaneous cooling-sensitive receptors can work as thermostats of skin temperature against cooling. However, molecule of the thermostat is not known. Here, we studied whether cooling-sensitive TRPM8 channels act as thermostats. TRPM8 in
Koji Tajino +5 more
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The Role and Function of TRPM8 in the Digestive System
BiomoleculesTransient receptor potential (TRP) melastatin member 8 (TRPM8) is a non-selective cation channel that can be activated by low temperatures (8–26 °C), cooling agents (including menthol analogs such as menthol, icilin, and WS-12), voltage, and ...
Zunan Wu +6 more
doaj +3 more sources