Results 21 to 30 of about 6,833 (180)

TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α

Cell Death and Disease, 2022
Impairment of liver regeneration leads to severe morbidity in acute and chronic severe liver disease. Transient receptor potential melastain 8 (TRPM8) is involved in a variety of processes, including temperature sensing, ion homeostasis, and cell ...
Xiaohua Lei, Qiang Liu, Wei Qin, Qing Tong, Zhenghao Li, Wendi Xu, Guoxing Liu, Jie Fu, Ju Zhang, Tao Kuang, Yaoli Shao, Chun Liu, Yu Fang, Zhenyu Cao, Likun Yan, Zhiqiang Liu, Siyuan Liu, Hirofumi Yamamoto, Masaki Mori, Xin M. Liang, Xundi Xu   +20 more
doaj   +1 more source

Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activation. [PDF]

PLoS ONE, 2014
The mammalian transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia. TRPM8 is activated by cold temperature or compounds that cause a cooling sensation, such as menthol or icilin.
Silke Miller, Sara Rao, Weiya Wang, Hantao Liu, Judy Wang, Narender R Gavva   +5 more
doaj   +1 more source

Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy

Frontiers in Oncology, 2020
The calcium-permeable cation channel TRPM8 (transient receptor potential melastatin 8) is a member of the TRP superfamily of cation channels that is upregulated in various types of cancer with high levels of autophagy, including prostate, pancreatic ...
Yuan Huang, Shi Li, Zhenhua Jia, Weiwei Zhao, Cefan Zhou, Rui Zhang, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Jingfeng Tang   +9 more
doaj   +1 more source

Structure of human TRPM8 channel

Communications Biology, 2022
SUMMARY TRPM8 is a calcium ion channel that is activated by multiple factors, such as temperature, voltage, pressure, and osmolality. It is a therapeutic target for anticancer drug development, and its modulators can be utilized for several pathological conditions.
Sergii Palchevskyi, Mariusz Czarnocki-Cieciura, Giulio Vistoli, Silvia Gervasoni, Elżbieta Nowak, Andrea R. Beccari, Marcin Nowotny, Carmine Talarico   +7 more
openaire   +5 more sources

Targeting TRPM8 for Pain Relief [PDF]

The Open Pain Journal, 2013
Transient receptor potential melastatin 8 (TRPM8) is a non-selective cation channel activated by cold temperature and cooling agents. TRPM8 is expressed in peripheral cold thermoreceptors and plays a fundamental role in sensing mild, cool temperatures.
Fernández-Peña, Carlos, Viana, Félix
openaire   +2 more sources

TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling

Cell & Bioscience, 2022
Background Liver fibrosis represent a major global health care burden. Data emerging from recent advances suggest TRPM8, a member of the transient receptor potential (TRP) family of ion channels, plays an essential role in various chronic inflammatory ...
Qiang Liu, Xiaohua Lei, Zhenyu Cao, Ju Zhang, Likun Yan, Jie Fu, Qing Tong, Wei Qin, Yaoli Shao, Chun Liu, Zhiqiang Liu, Zicheng Wang, Yuan Chu, Ge Xu, Siyuan Liu, Xueyi Wen, Hirofumi Yamamoto, Masaki Mori, Xin. M. Liang, Xundi Xu   +19 more
doaj   +1 more source

TRPM8 Channel Promotes the Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells

Frontiers in Cell and Developmental Biology, 2021
Various families of ion channels have been characterized in mesenchymal stem cells (MSCs), including some members of transient receptor potential (TRP) channels family.
Juan C. Henao, Adriana Grismaldo, Alfonso Barreto, Viviana M. Rodríguez-Pardo, Claudia Camila Mejía-Cruz, Efrain Leal-Garcia, Rafael Pérez-Núñez, Patricio Rojas, Ramón Latorre, Ingrid Carvacho, Yolima P. Torres   +10 more
doaj   +1 more source

Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice. [PDF]

PLoS ONE, 2011
TRPM8 (Transient Receptor Potential Melastatin-8) is a cold- and menthol-gated ion channel necessary for the detection of cold temperatures in the mammalian peripheral nervous system.
Wendy M Knowlton, Richard L Daniels, Radhika Palkar, Daniel D McCoy, David D McKemy   +4 more
doaj   +1 more source

Cooling the Itch via TRPM8 [PDF]

Journal of Investigative Dermatology, 2018
Cooling is an effective temporary remedy for itch, bringing welcome relief to itchy insect bites, nettle stings, poison ivy, atopic dermatitis, and psoriasis. Menthol, causing a cooling sensation, has similar itch-relieving effects. Palkar et al. demonstrate that TRPM8, a menthol- and cold-activated ion channel, is essential for cooling to relieve itch,
Boyi, Liu, Sven-Eric, Jordt
openaire   +2 more sources

Menthol evokes Ca2+ signals and induces oxidative stress independently of the presence of TRPM8 (menthol) receptor in cancer cells

Redox Biology, 2018
Menthol is a naturally occurring monoterpene alcohol possessing remarkable biological properties including antipruritic, analgesic, antiseptic, anti-inflammatory and cooling effects.
Mustafa Nazıroğlu, Walter Blum, Katalin Jósvay, Bilal Çiğ, Thomas Henzi, Zoltán Oláh, Csaba Vizler, Beat Schwaller, László Pecze   +8 more
doaj   +1 more source