Results 31 to 40 of about 6,833 (180)

Endogenous Trigeminal Neurons Induce Schwann Differentiation of Donor Stem Cells in Dental Pulp Regeneration via Reciprocal Extracellular Vesicles Interplay

Exploration, EarlyView.
Our study demonstrates that the host TG coordinates with heterologously implanted SHED to regenerate functional dental pulp through reciprocal EVs’ interplay. EVs derived from implanted stem cells migrate to the host TG to activate axonal regeneration.
Wanmin Zhao, Wenzhe Wang, Jia Guo, Jiani Liu, Wei Wang, Dihao Tao, Jiayi Dong, Zhonghan Li, Shiyu Liu, Songtao Shi, Tao Chen, Yan Jin, Bei Li   +12 more
wiley   +1 more source

Ligand Stoichiometry of TRPM8 [PDF]

Biophysical Journal, 2010
Temperature-sensitive TRP channels (thermoTRPs) play a key role in somatosensory thermosensation. Several thermoTRPs, including the heat-activated TRPV1 and the cold-activated TRPM8, are not only sensitive to changes in temperature but also to ligands that evoke a thermal sensation, such as the ‘hot pepper’ compound capsaicin (TRPV1) and the cooling ...
Voets, Thomas, Janssens, Annelies
openaire   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Central connectivity of transient receptor potential melastatin 8-expressing axons in the brain stem and spinal dorsal horn.

PLoS ONE, 2014
Transient receptor potential melastatin 8 (TRPM8) ion channels mediate the detection of noxious and innocuous cold and are expressed by primary sensory neurons, but little is known about the processing of the TRPM8-mediated cold information within the ...
Yun Sook Kim, Jun Hong Park, Su Jung Choi, Jin Young Bae, Dong Kuk Ahn, David D McKemy, Yong Chul Bae   +6 more
doaj   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Estrogen regulation of TRPM8 expression in breast cancer cells

BMC Cancer, 2010
Background The calcium-permeable cation channel TRPM8 (melastatin-related transient receptor potential member 8) is over-expressed in several cancers.
Sevestre Henri, Telliez Marie-Sophie, Gautier Mathieu, Dhennin-Duthille Isabelle, Guilbert Arnaud, Chodon Dechen, Ouadid-Ahidouch Halima   +6 more
doaj   +1 more source

Thermo-sensitive TRP channels and prevention of major chronic diseases

Di-san junyi daxue xuebao, 2022
American scientists David Julius and Ardem Patapoutian won the Nobel Prize in physiology or medicine in 2021 for their groundbreaking discoveries of capsaicin receptor TRPV1 and menthol receptor TRPM8, revealing the secrets of temperature perception. The
ZHU Zhiming, LIU Daoyan
doaj   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Research Progress on Upper Airway Cough Syndrome

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley   +1 more source

Control of motor coordination by transient receptor potential melastatin 8 through γ-aminobutyric acidergic circuit modulation in the male mouse cerebellum

Scientific Reports
Transient receptor potential melastatin 8 (TRPM8) is a non-selective cation channel that is activated by mild cooling and chemical agents. Although TRPM8 is widely expressed in the peripheral and central nervous systems, its cerebellar distribution and ...
Mayuka Koyama, Koki Harada, Naoko Takizawa, Shinji Kobuchi, Miwa Kambara, Hikaru Tanaka, Riona Araki, Yuri Yamada, Yukako Ito, Kazuyuki Takata, Shinichi Kato, Kenjiro Matsumoto   +11 more
doaj   +1 more source