Results 51 to 60 of about 6,833 (180)

TRPM8 Is Required for Cold Sensation in Mice [PDF]

Neuron, 2007
ThermoTRPs, a subset of the Transient Receptor Potential (TRP) family of cation channels, have been implicated in sensing temperature. TRPM8 and TRPA1 are both activated by cooling; however, it is unclear whether either ion channel is required for thermosensation in vivo.
Dhaka, Ajay, Murray, Amber N., Mathur, Jayanti, Earley, Taryn J., Petrus, Matt J., Patapoutian, Ardem   +5 more
openaire   +2 more sources

Defining cellular mechanisms important for painful chemotherapy‐related neuropathy using long‐term primary cultures of nociceptors

The FEBS Journal, EarlyView.
Basic excitability alterations that drive irregular spontaneous activity in primary nociceptors during chemotherapy‐induced peripheral neuropathy. Using an in vitro model of repeated paclitaxel application to dorsal root ganglion neurons that produces progressive axonal degeneration, Lamberti and colleagues show that all three basic excitability ...
Edgar T. Walters
wiley   +1 more source

Structural insights into TRPM8 inhibition and desensitization [PDF]

Science, 2019
Responding to the cold Mint tastes cool because the active component, menthol, activates the receptor and calcium channel TRPM8, which also responds to cold temperatures. Previous structures have revealed the architecture of TRPM8 and how it binds ligands but not its gating mechanism.
Melinda M. Diver, Yifan Cheng, David Julius   +2 more
openaire   +4 more sources

TRPM8 overexpression suppresses hepatocellular carcinoma progression and improves survival by modulating the RTP3/STAT3 pathway

Cancer Medicine
Background and Aims Hepatocellular carcinoma (HCC) is a malignant tumour associated with high morbidity and mortality rates worldwide. Recently, TRPM8 was reported to play an important role in tumour progression. However, the precise role of TRPM8 in HCC
Lichan Chen, Nansong Xu, DongMei Gou, Jianning Song, Mingqin Zhou, Yajun Zhang, Haohua Zhang, Liwen Zhu, Weihong Huang, Yue Zhu, Cheng Gao, Dayong Gu, Yong Xu, Hongzhong Zhou   +13 more
doaj   +1 more source

Studying molecular interactions of synthetic glucocorticoids with TRPM8 by molecular docking

Бюллетень сибирской медицины
Aim. To carry out in silico screening of interactions of synthetic glucocorticoids with TRPM8.Materials and methods. Information on the structure of the ligands was obtained from the PubChem chemical database in sdf format.
P. D. Timkin, D. D. Kotelnikov, E. A. Timofeev, D. E. Naumov, E. A. Borodin   +4 more
doaj   +1 more source

Swiss Practice Recommendations for Chronic Prurigo Including Prurigo Nodularis

International Journal of Dermatology, EarlyView.
Chronic prurigo, including prurigo nodularis, is a chronic, often treatment‐refractory condition characterized by persistent pruritus and chronic scratch lesions. Advances in the understanding of its underlying pathophysiology have enabled the development of novel targeted therapies; however, management remains challenging due to the expanding range of
Simon M. Mueller, Helmut Beltraminelli, Wolf‐Henning Boehncke, Maximilian Böhm, Antonio Cozzio, Peter Häusermann, Ahmad Jalili, Antonios G. A. Kolios, Claudia Lang, Eva Loos, Christoph Schlapbach, Curdin Conrad   +11 more
wiley   +1 more source

Signal Transduction of Transient Receptor Potential TRPM8 Channels: Role of PIP5K, Gq-Proteins, and c-Jun

Molecules
Transient receptor potential melastatin-8 (TRPM8) is a cation channel that is activated by cold and “cooling agents” such as menthol and icilin, which induce a cold sensation.
Gerald Thiel, Oliver G. Rössler
doaj   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel

Nature Communications, 2020
Menthol in mints elicits a coolness sensation by selective activation of TRPM8 ion channel. Here authors dock menthol to TRPM8 and systematically validate their menthol binding models with thermodynamic mutant cycle analysis in functional tests, and shed
Lizhen Xu, Yalan Han, Xiaoying Chen, Aerziguli Aierken, Han Wen, Wenjun Zheng, Hongkun Wang, Xiancui Lu, Zhenye Zhao, Cheng Ma, Ping Liang, Wei Yang, Shilong Yang, Fan Yang   +13 more
doaj   +1 more source

Oral Lesions and Dental Status in Individuals Using Oral Tobacco‐Free Nicotine Pouches

Oral Diseases, EarlyView.
ABSTRACT Objectives Users of Swedish nicotine pouches and traditional oral tobacco‐derived pouches were compared to non‐users for clinical tissue responses and oral health status. In addition, the habits associated with snus use were also evaluated. Material and Methods In this cross‐sectional study, participants aged 18–30 were recruited from nine ...
Masoumeh Daneshian, Lars Fredriksson, Pia Skott, Karin Garming Legert   +3 more
wiley   +1 more source