Results 61 to 70 of about 6,833 (180)

The cold‐water immersion recovery–adaptation paradox: Reconciling acute parasympathetic and analgesic benefits with chronic hypertrophy attenuation

Experimental Physiology, EarlyView.
Abstract Cold‐water immersion (CWI) is among the most widely used post‐exercise recovery modalities in elite sport and clinical rehabilitation, yet a fundamental paradox now emerges from the evidence: the same protocols that accelerate parasympathetic reactivation and reduce perceived muscle soreness also suppress the molecular and cellular machinery ...
Jose Francisco Tornero‐Aguilera, Jose Lozano‐Meca, Miguel López‐Moreno, Edgar Simón Sancho‐Haro, Mario Muñoz‐López, Eneko Baz‐Valle, José Francisco López‐Gil, Rodrigo Yáñez‐Sepúlveda, Vicente Javier Clemente‐Suárez   +8 more
wiley   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations

BMC Urology, 2006
Background The recent identification of the cold-menthol sensory receptor (TRPM8; CMR1), provides us with an opportunity to advance our understanding of its role in the pathophysiology of bladder dysfunction, and its potential mediation of the bladder ...
Benham Christopher D, Smith Graham D, Selmer Inger S, Corcoran Stacey L, Yiangou Yiangos, Mukerji Gaurav, Bountra Chas, Agarwal Sanjiv K, Anand Praveen   +8 more
doaj   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, Volume 13, Issue 56, 9 October 2026.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Characterization Of Selective TRPM8 Ligands And Their Structure Activity Response (S.A.R) Relationship

Journal of Pharmacy & Pharmaceutical Sciences, 2010
PURPOSE: Transient receptor potential melastatin-8 (TRPM8) is an ion channel expressed extensively in sensory nerves, human prostate and overexpressed in a variety of cancers including prostate, breast, lung, colon and skin melanomas.
Muhammad Azhar Sherkheli, Angela K. Vogt-Eisele, Daniel Bura, Leopoldo R. Beltrán Márques, Günter Gisselmann, Hanns Hatt   +5 more
doaj   +1 more source

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

Genetic aspects of digestive diseases. Part 1

Терапевтический архив, 2010
The paper presents the data available in the literature on mutations in known genes in pancreatitis, such as cationic trypsinogen (PRSS1), pancreatic secretory trypsin inhibitor (PSTI/SPINK1), cystic fibrosis (CFTR), and apolipoprotein E (APOE) genes, as
Irina Nikolaevna Grigor'eva, Tat'yana Mikhaylovna Nikitenko, Aleksandr Vilenovich Tikhonov, Tat'yana Ivanovna Romanova, V N Maksimov, Elena Vladimirovna Shakhtshneyder, Sof'ya Konstantinovna Malyutina, Mikhail Ivanovich Voevoda, I N Grigoryeva, T M Nikitenko, A V Tikhonov, T I Romanova, V N Maksimov, E V Shakhtshneider, S K Malyutina, M I Voyevoda   +15 more
doaj  

Longitudinal Changes in Nasal Airflow and Patient‐Reported Outcomes Following Acoustic Nasal Therapy: A Pilot Study

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Acoustic nasal therapy has emerged as a potential non‐pharmacological adjunct for allergic rhinitis (AR) and chronic rhinosinusitis (CRS), but longitudinal evidence on its effects on nasal airflow and patient‐reported outcomes remains limited.
Jude Oluwapelumi Alao, Jim Bartley, Chris Puli'uvea, David White, Kevin Lee, Kelvin E. M. Lau   +5 more
wiley   +1 more source