Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand [PDF]
Molecules, 2013 Pregnenolone sulfate is a steroid metabolite with a plethora of actions and functions. As a neurosteroid, pregnenolone sulfate modulates a variety of ion channels, transporters, and enzymes.
Christian Harteneck
exaly +4 more sources
Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study [PDF]
The Journal of Headache and Pain, 2021 Background Neurosteroids affect the balance between neuroexcitation and neuroinhibition but have been little studied in migraine. We compared the serum levels of pregnenolone sulfate, pregnanolone and estradiol in women with menstrually-related migraine ...
Cecilia Rustichelli +7 more
doaj +2 more sources
Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations [PDF]
Frontiers in EndocrinologyBackgroundType 2 diabetes (T2D) is increasing its burden worldwide; therefore, research focused on its prediction and prevention is essential.MethodsWe performed an untargeted metabolomics analysis using ultra high-performance liquid chromatography-mass ...
Maria Barranco-Altirriba +47 more
doaj +2 more sources
Pregnenolone sulfate induces transcriptional and immunoregulatory effects on T cells [PDF]
Scientific ReportsPregnenolone sulfate is a steroid metabolite of the steroidogenesis precursor, pregnenolone, with similar functional properties, including immunosuppression.
Yasmine El Hajj +6 more
doaj +2 more sources
L-3,3',5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors. [PDF]
PLoS ONE, 2019 The nicotinic acetylcholine receptor (nAChR) is an excitatory pentameric ligand-gated ion channel (pLGIC), homologous to the inhibitory γ-aminobutyric acid (GABA) type A receptor targeted by pharmaceuticals and endogenous sedatives.
Steven X Moffett +3 more
doaj +2 more sources
Pregnenolone sulfate potentiates tetrodotoxin-resistant Na+ channels to increase the excitability of dural afferent neurons in rats [PDF]
The Journal of Headache and PainBackground Although peripheral administration of pregnenolone sulfate (PS) has been reported to produce pronociceptive effects, the mechanisms by which PS modulates the excitability of nociceptive neurons are poorly understood.
Il-Sung Jang, Michiko Nakamura
doaj +2 more sources
Stimulation of Transient Receptor Potential Channels TRPM3 and TRPM8 Increases Human Prostaglandin Endoperoxide Synthase-2 Promoter Activity [PDF]
MoleculesThe transient receptor potential channels TRPM3 and TRPM8 are cation channels that regulate numerous cellular activities, including thermo- and pain sensation.
Nikolas Brandmeier +2 more
doaj +2 more sources
Frontiers in Pharmacology, 2021 Organic anion transporting polypeptide 2B1 (OATP2B1, gene SLCO2B1) is an uptake transporter that is thought to determine drug disposition and in particular, the oral absorption of medications.
Samantha Medwid +12 more
doaj +1 more source
Pregnenolone sulfate potentiates the inwardly rectifying K channel Kir2.3. [PDF]
PLoS ONE, 2009 BACKGROUND:Neurosteroids have various physiological and neuropsychopharmacological effects. In addition to the genomic effects of steroids, some neurosteroids modulate several neurotransmitter receptors and channels, such as N-methyl-D-aspartate ...
Toru Kobayashi +2 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that play a crucial role in excitatory synaptic transmission in the central nervous system.
Kai Langer +4 more
doaj +1 more source