Results 1 to 10 of about 12,871 (217)
Structural insights into opposing actions of neurosteroids on GABAA receptors
Nature Communications, 2023 γ-Aminobutyric acid type A (GABAA) receptors mediate fast inhibitory signaling in the brain and are targets of numerous drugs and endogenous neurosteroids.
Dagimhiwat H. Legesse +7 more
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Neurosteroids and Focal Epileptic Disorders [PDF]
International Journal of Molecular Sciences, 2020 Neurosteroids are a family of compounds that are synthesized in principal excitatory neurons and glial cells, and derive from the transformation of cholesterol into pregnenolone.
Massimo AVOLI +2 more
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Human Microglia Synthesize Neurosteroids to Cope with Rotenone-Induced Oxidative Stress
Antioxidants, 2023 We obtained evidence that mouse BV2 microglia synthesize neurosteroids dynamically to modify neurosteroid levels in response to oxidative damage caused by rotenone.
Cecilia Rustichelli +2 more
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Neurosteroids Progesterone and Dehydroepiandrosterone: Molecular Mechanisms of Action in Neuroprotection and Neuroinflammation [PDF]
PharmaceuticalsNeurosteroids pregnenolone, progesterone, allopregnanolone, and dehydroepiandrosterone have been actively studied in the last years as candidates for the treatment of neurodegenerative diseases and postinjury rehabilitation.
Tatiana A. Fedotcheva +1 more
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Neurosteroids in Schizophrenia: Pathogenic and Therapeutic Implications
Frontiers in Psychiatry, 2018 Neurosteroids are a group of important endogenous molecules affecting many neural functions in the brain. Increasing evidence suggests a possible role of these neurosteroids in the pathology and symptomatology of schizophrenia (SZ) and other mental ...
HuaLin Cai +8 more
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Neurosteroids as regulators of neuroinflammation
Frontiers in Neuroendocrinology, 2019 Neuroinflammation is a physiological protective response in the context of infection and injury. However, neuroinflammation, especially if chronic, may also drive neurodegeneration. Neurodegenerative diseases, such as multiple sclerosis (MS), Alzheimer's
Achille Gravanis +2 more
exaly +5 more sources
Frontiers in Neuroscience, 2020 Mounting experimental evidence demonstrate that sex neuroactive steroids (neurosteroids) are essential for memory formation. Neurosteroids have a profound impact on the function and structure of neural circuits and their local synthesis is necessary for ...
Alessandro Tozzi +2 more
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Genomic and Non-genomic Action of Neurosteroids in the Peripheral Nervous System
Frontiers in Neuroscience, 2020 Since the former evidence of biologic actions of neurosteroids in the central nervous system, also the peripheral nervous system (PNS) was reported as a structure affected by these substances.
Alessandra Colciago +3 more
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Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond
Neurobiology of Stress, 2019 The recent FDA approval of the neurosteroid, brexanolone (allopregnanolone), as a treatment for women with postpartum depression, and successful trials of a related neuroactive steroid, SGE-217, for men and women with major depressive disorder offer the ...
Charles F. Zorumski +3 more
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Neurosteroids: a lifelong impact on brain health [PDF]
Frontiers in Behavioral NeuroscienceNeurosteroids are critical regulators of brain function, exerting profound effects on neurodevelopment, emotional regulation, cognition, and resilience to stress across the lifespan.
Najah L. Walton, Jamie L. Maguire
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