Frontiers in Endocrinology, 2011 This review highlights the role of major endogenous neurosteroids in seizure disorders and the promise of neurosteroid replacement therapy in epilepsy. Neurosteroids are endogenous modulators of seizure susceptibility.
Doodipala Samba Reddy
exaly +3 more sources
Neurosteroids: a lifelong impact on brain health [PDF]
Frontiers in Behavioral NeuroscienceNeurosteroids are critical regulators of brain function, exerting profound effects on neurodevelopment, emotional regulation, cognition, and resilience to stress across the lifespan.
Najah L. Walton, Jamie L. Maguire
doaj +2 more sources
The endogenous cannabinoid system gates plasticity of tonic GABA inhibition. [PDF]
J PhysiolAbstract figure legend Postsynaptic depolarisation and increases in intracellular Ca2+ ([Ca2+]i) trigger the synthesis of endocannabinoids (eCBs), which are hypothesised to enhance tonic GABAergic inhibition via two primary pathways. In the proposed autocrine mechanism, eCBs activate postsynaptic somatodendritic or mitochondrial CB1 receptors ...
Colangeli R, Conti F.
europepmc +2 more sources
Structural modifications to pregnane neurosteroids alter inhibition of LPS/Lipid A binding at the MD-2 activation site within the TLR4 signaling complex [PDF]
Frontiers in ImmunologyNeurosteroids have emerged as promising candidates for treatment for neuroinflammatory diseases, distinct from their classical GABAergic effects. We previously demonstrated that 3α,5α-THP inhibits binding of the Lipid A moiety of lipopolysaccharide to ...
Alejandro G. Lopez +9 more
doaj +2 more sources
Neurosteroids in Schizophrenia: Pathogenic and Therapeutic Implications
Frontiers in Psychiatry, 2018 Neurosteroids are a group of important endogenous molecules affecting many neural functions in the brain. Increasing evidence suggests a possible role of these neurosteroids in the pathology and symptomatology of schizophrenia (SZ) and other mental ...
Hualin Cai, Ting Cao, Jeffrey K Yao
exaly +3 more sources
Human Microglia Synthesize Neurosteroids to Cope with Rotenone-Induced Oxidative Stress
Antioxidants, 2023 We obtained evidence that mouse BV2 microglia synthesize neurosteroids dynamically to modify neurosteroid levels in response to oxidative damage caused by rotenone.
Chiara Lucchi +2 more
exaly +3 more sources
Neurosteroids Progesterone and Dehydroepiandrosterone: Molecular Mechanisms of Action in Neuroprotection and Neuroinflammation [PDF]
PharmaceuticalsNeurosteroids pregnenolone, progesterone, allopregnanolone, and dehydroepiandrosterone have been actively studied in the last years as candidates for the treatment of neurodegenerative diseases and postinjury rehabilitation.
Tatiana A. Fedotcheva +1 more
doaj +2 more sources
Neurosteroids and GABAergic signaling in health and disease
Biomolecular Concepts, 2013 Endogenous neurosteroids such as allopregnanolone, allotetrahydrodeoxycorticosterone, and androstanediol are synthesized either de novo in the brain from cholesterol or are generated from the local metabolism of peripherally derived progesterone or ...
Georgina Mackenzie, Jamie Maguire
exaly +2 more sources
The endogenic neurosteroid system and its role in the pathogenesis and therapy of mental disorders
Research Results in Pharmacology, 2023 Introduction: Although neurosteroids have been relatively recently discovered, their significant role in the neurochemical processes and pathogenesis of a number of psychiatric and neurological disorders is now quite clear.
Sakeena P. Bairamova +7 more
doaj +1 more source
Structural insights into opposing actions of neurosteroids on GABAA receptors
Nature Communications, 2023 γ-Aminobutyric acid type A (GABAA) receptors mediate fast inhibitory signaling in the brain and are targets of numerous drugs and endogenous neurosteroids.
Dagimhiwat H. Legesse +7 more
doaj +1 more source