Results 11 to 20 of about 5,285 (165)
Neuroprotective actions of neurosteroids [PDF]
Frontiers in Endocrinology, 2011 Neurosteroids were initially defined as steroid hormones locally synthesized within the nervous tissue. Subsequently, they were described as steroid hormone derivatives that devoid hormonal action but still affect neuronal excitability through modulation
Kinga eBorowicz +4 more
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Role of Hormones and Neurosteroids in Epileptogenesis [PDF]
Frontiers in Cellular Neuroscience, 2013 This article describes the emerging evidence of hormonal influence on epileptogenesis, which is a process whereby a brain becomes progressively epileptic due to an initial precipitating event of diverse origin such as brain injury, stroke, infection, or ...
D Samba eReddy
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Neurosteroids and Seizure Activity [PDF]
Frontiers in Endocrinology, 2020 Still circa 25% to 30% of patients with epilepsy cannot be efficiently controlled with available antiepileptic drugs so newer pharmacological treatment options have been continuously searched for.
Barbara Miziak +2 more
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Researh Topic : Neurosteroids [PDF]
Frontiers in Endocrinology, 2012 Thirty years ago, the group of Baulieu and colleagues discovered that certain steroid hormones were present in higher amounts in the brain than in the plasma, and also found that suppression of circulating steroids by adrenalectomy and castration does not affect the concentration of pregnenolone, dehydroepiandrosterone, and their sulfate esters in the ...
Hubert eVaudry, Kazuyoshi eTsutsui
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Neurosteroids and epilepsy [PDF]
Current Opinion in Neurology, 2010 Neurosteroids are a family of compounds synthesized directly in the brain by transforming cholesterol into pregnenolone, which is then converted to compounds such as allopregnanolone and allotetrahydrodeoxycorticosterone. In view of their ability to modulate neurotransmission, neurosteroids may influence the clinical course of epileptic disorders.
Giuseppe Biagini +2 more
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iScience, 2020 Summary: Neuroactive steroids, termed neurosteroids, are synthesized locally in the brain and influence biological functions including cognition and behavior.
Kanako Maehata +8 more
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Frontiers in Neuroscience, 2020 Mounting experimental evidence demonstrate that sex neuroactive steroids (neurosteroids) are essential for memory formation. Neurosteroids have a profound impact on the function and structure of neural circuits and their local synthesis is necessary for ...
Alessandro Tozzi +2 more
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Neurosteroids and their role in sex-specific epilepsies
Neurobiology of Disease, 2014 Neurosteroids are involved in sex-specific epilepsies. Allopregnanolone and related endogenous neurosteroids in the brain control excessive neuronal excitability and seizure susceptibility.
Doodipala Samba Reddy
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GABAergic neuroactive steroids: a new frontier in bipolar disorders?
Behavioral and Brain Functions, 2012 Neurosteroids are synthesized in the brain and modulate brain excitability. There is increasing evidence of their sedative, anesthetic and antiseizure properties, as well as their influence on mood.
Carta Mauro Giovanni +2 more
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Genomic and Non-genomic Action of Neurosteroids in the Peripheral Nervous System
Frontiers in Neuroscience, 2020 Since the former evidence of biologic actions of neurosteroids in the central nervous system, also the peripheral nervous system (PNS) was reported as a structure affected by these substances.
Alessandra Colciago +3 more
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