Results 11 to 20 of about 12,871 (217)
Neuroprotective actions of neurosteroids [PDF]
Frontiers in Endocrinology, 2011 Neurosteroids were initially defined as steroid hormones locally synthesized within the nervous tissue. Subsequently, they were described as steroid hormone derivatives that devoid hormonal action but still affect neuronal excitability through modulation
Kinga eBorowicz +4 more
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Neurosteroids and Seizure Activity [PDF]
Frontiers in Endocrinology, 2020 Still circa 25% to 30% of patients with epilepsy cannot be efficiently controlled with available antiepileptic drugs so newer pharmacological treatment options have been continuously searched for.
Barbara Miziak +2 more
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Neurosteroids And Epileptogenesis
Journal of Neuroendocrinology, 2013 Epileptogenesis is defined as the latent period at the end of which spontaneous recurrent seizures occur. This concept has been recently re-evaluated to include exacerbation of clinically-manifested epilepsy.
BIAGINI, Giuseppe +7 more
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Gender and Neurosteroids: Implications for Brain Function, Neuroplasticity and Rehabilitation
International Journal of Molecular Sciences, 2023 Neurosteroids are synthesized de novo in the nervous system; they mainly moderate neuronal excitability, and reach target cells via the extracellular pathway.
L. Raciti +4 more
semanticscholar +2 more sources
Treatment of Postpartum Depression with Neurosteroids [PDF]
Neurologijos seminaraiNeurosteroids, such as allopregnanolone, are primarily synthesized substances in the central nervous system which influence processes occurring in the brain.
Reda Stankevičiūtė, Robertas Strumila
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Role of Hormones and Neurosteroids in Epileptogenesis [PDF]
Frontiers in Cellular Neuroscience, 2013 This article describes the emerging evidence of hormonal influence on epileptogenesis, which is a process whereby a brain becomes progressively epileptic due to an initial precipitating event of diverse origin such as brain injury, stroke, infection, or ...
D Samba eReddy
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Synthetic neurosteroids on brain protection [PDF]
Neural Regeneration Research, 2015 Neurosteroids, like allopregnanolone and pregnanolone, are endogenous regulators of neuronal excitability. Inside the brain, they are highly selective and potent modulators of GABA A receptor activity.
Mariana Rey, Héctor Coirini
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Neurosteroids and the mesocorticolimbic system
Neuroscience & Biobehavioral Reviews, 2023 The mesocorticolimbic system coordinates executive functions, such as working memory and behavioral flexibility. This circuit includes dopaminergic projections from the ventral tegmental area to the nucleus accumbens and medial prefrontal cortex. In this
Désirée R. Seib +4 more
semanticscholar +3 more sources
Neurosteroids in Glioma: A Novel Therapeutic Concept
LifeGlioma, a diverse group of brain and spinal cord tumors arising from glial cells, is characterized by varying degrees of malignancy, with some types exhibiting highly aggressive behavior, rapid proliferation, and invasive growth patterns, posing ...
Ava Hogan, Melike Mut
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Structural modifications to pregnane neurosteroids alter inhibition of LPS/Lipid A binding at the MD-2 activation site within the TLR4 signaling complex [PDF]
Frontiers in ImmunologyNeurosteroids have emerged as promising candidates for treatment for neuroinflammatory diseases, distinct from their classical GABAergic effects. We previously demonstrated that 3α,5α-THP inhibits binding of the Lipid A moiety of lipopolysaccharide to ...
Alejandro G. Lopez +9 more
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