Results 41 to 50 of about 12,871 (217)
Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors. [PDF]
, 2015 GABAA receptors are important for inhibition in the CNS where neurosteroids and protein kinases are potent endogenous modulators. Acting individually, these can either enhance or depress receptor function, dependent upon the type of neurosteroid or ...
Adams, JM +5 more
core +1 more source
Frontiers in Endocrinology, 2011 This review highlights the role of major endogenous neurosteroids in seizure disorders and the promise of neurosteroid replacement therapy in epilepsy. Neurosteroids are endogenous modulators of seizure susceptibility.
D. Samba eReddy
doaj +1 more source
Brexanolone, a First-In-Class Neurosteroid Medication: Mechanism of Action, Clinical, and Translational Science. [PDF]
Clin Transl SciABSTRACT Given the increasing prevalence of postpartum depression (PPD) and the stigma associated with this condition, it is essential to address this significant health concern. Brexanolone is an FDA‐approved treatment for PPD that works by positive‐allosteric modulation of type A γ‐aminobutyric acid (GABAA) receptors.
Gayanova L +4 more
europepmc +2 more sources
Mitochondria, neurosteroids and biological rhythms : implications in health and disease states [PDF]
, 2015 Mitochondria are considered as the “powerhouses” of cells because they synthesize the universal source of energy under the form of adenosine triphosphate (ATP) molecules via oxidative phosphorylation from nutritional sources. Thus, impaired mitochondrial
Grimm, Amandine
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Neurosteroids and their role in sex-specific epilepsies
Neurobiology of Disease, 2014 Neurosteroids are involved in sex-specific epilepsies. Allopregnanolone and related endogenous neurosteroids in the brain control excessive neuronal excitability and seizure susceptibility.
Doodipala Samba Reddy
doaj +1 more source
GABAergic neuroactive steroids: a new frontier in bipolar disorders?
Behavioral and Brain Functions, 2012 Neurosteroids are synthesized in the brain and modulate brain excitability. There is increasing evidence of their sedative, anesthetic and antiseizure properties, as well as their influence on mood.
Carta Mauro Giovanni +2 more
doaj +1 more source
When CO<sub>2</sub> sensing fails: Protective effects of sex hormones and potential mechanisms. [PDF]
J NeuroendocrinolAbstract Breathing movements driven by the brainstem rhythmogenic neural networks rely on chemosensory inputs to produce a motor output that is homeostatically adjusted to the prevailing metabolic demand. The central CO2 chemoreflex is a critical component of respiratory neural circuitry, as defects in these sensors cause hypoventilation syndromes ...
Janes TA, Cardani S, Pagliardini S.
europepmc +2 more sources
Essays in Biochemistry, 2020 Neurosteroids are steroid hormones synthesised de novo in the brain and peripheral nervous tissues. In contrast to adrenal steroid hormones that act on intracellular nuclear receptors, neurosteroids directly modulate plasma membrane ion channels and ...
Emyr Lloyd-Evans, Helen Waller-Evans
semanticscholar +1 more source
Pineal Neurosteroids: Biosynthesis and Physiological Functions
Frontiers in Endocrinology, 2020 Similar to the adrenal glands, gonads, and placenta, vertebrate brains also produce various steroids, which are known as “neurosteroids.” Neurosteroids are mainly synthesized in the hippocampus, hypothalamus, and cerebellum; however, it has recently been
Shogo Haraguchi, Kazuyoshi Tsutsui
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Neurosteroids: current perspective in therapy of neuropsychiatric disorders [PDF]
, 2019 Neurosteroids are natural or synthetic steroid derivatives which act locally in brain by modulating neuronal excitability. The objective of this study is to analyze available literature on classification, biosynthesis and mechanism of action, and ...
Maity, Nivedita +2 more
core +1 more source