Results 61 to 70 of about 5,285 (165)

Of cilia, titin, and neurosteroids [PDF]

Journal of General Physiology, 2014
This month’s installment of Generally Physiological discusses a calcium compartment in primary cilia, how changes in titin splicing can lead to skeletal muscle myopathy, and a negative feedback loop whereby a neurosteroid protects against hyperactivation of type-1 cannabinoid (CB1) receptors.
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Overview of the Molecular Steps in Steroidogenesis of the GABAergic Neurosteroids Allopregnanolone and Pregnanolone

Chronic Stress, 2018
Allopregnanolone and pregnanolone—neurosteroids synthesized from progesterone in the brain, adrenal gland, ovary and testis—have been implicated in a range of neuropsychiatric conditions including seizure disorders, post-traumatic stress disorder, major ...
Jennifer J. Liang, Ann M. Rasmusson
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Pregnanolone-Based Prodrugs as a Strategy for Neuroprotective Drug-Like Compounds: Pregnanolone Pyroglutamate and Its Age‑dependent Anticonvulsant Effects in the 6-hz Seizure Model in Immature Rats

Drug Design, Development and Therapy
Pavel Mareš,1 Hana Chodounská,2 Ewa Szczurowska,2 Hana Kubová,1 Eva Kudova2 1Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic; 2Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech ...
Mareš P, Chodounská H, Szczurowska E, Kubová H, Kudova E   +4 more
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Neurosteroid Biosynthesis and Action in the Purkinje Cell

Journal of Experimental Neuroscience, 2009
It is now clearly established that steroids can be synthesized de novo by the vertebrate brain. Such steroids are called neurosteroids. To understand neurosteroid action in the brain, data on the regio- and temporal-specific synthesis of neurosteroids ...
Kazuyoshi Tsutsui
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Neurosteroid Metabolites of Gonadal Steroid Hormones in Neuroprotection: Implications for Sex Differences in Neurodegenerative Disease

Frontiers in Molecular Neuroscience, 2018
Gonadal steroid hormones are neurotrophic and neuroprotective. These effects are modulated by local metabolism of the hormones within the brain. Such control is necessary to maintain normal function, as several signaling pathways that are activated by ...
Ari Loren Mendell, Neil James MacLusky
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New Biosynthesis and Biological Actions of Avian Neurosteroids

Journal of Experimental Neuroscience, 2013
De novo neurosteroidogenesis from cholesterol occurs in the brain of various avian species. However, the biosynthetic pathways leading to the formation of neurosteroids are still not completely elucidated.
Kazuyoshi Tsutsui, Shogo Haraguchi, Kazuhiko Inoue, Hitomi Miyabara, Takayoshi Ubuka, Megumi Hatori, Tsuyoshi Hirota, Yoshitaka Fukada   +7 more
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Migraine and cluster headache show impaired neurosteroids patterns

The Journal of Headache and Pain, 2019
Background Perturbation of neuronal excitability contributes to migraine. Neurosteroids modulate the activity of γ-aminobutyric acid A and N-methyl-d-aspartate receptors, and might be involved in the pathogenesis of migraine.
Angela Koverech, Claudia Cicione, Luana Lionetto, Marta Maestri, Francesco Passariello, Elisabetta Sabbatini, Matilde Capi, Cristiano Maria De Marco, Martina Guglielmetti, Andrea Negro, Luisa Di Menna, Maurizio Simmaco, Ferdinando Nicoletti, Paolo Martelletti   +13 more
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Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides

Frontiers in Endocrinology, 2012
The enzymatic pathways leading to the synthesis of bioactive steroids in the brain are now almost completely elucidated in various groups of vertebrates and, during the last decade, the neuronal mechanisms involved in the regulation of neurosteroid ...
Jean-Luc eDo-Rego, Jae Young eSeong, Delphine eBurel, Jérôme eLEPRINCE, David eVaudry, David eVaudry, Van eLuu-The, Marie-Christine eTonon, Marie-Christine eTonon, Kazuyoshi eTsutsui, Georges ePelletier, Hubert eVaudry, Hubert eVaudry   +12 more
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Neurosteroids and GABA-A Receptor Function [PDF]

Frontiers in Endocrinology, 2011
Neurosteroids represent a class of endogenous steroids that are synthesized in the brain, the adrenals, and the gonads and have potent and selective effects on the GABAA-receptor. 3α-hydroxy A-ring reduced metabolites of progesterone, deoxycorticosterone, and testosterone are positive modulators of GABA(A)-receptor in a non-genomic manner ...
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Exploring the connection between several neurosteroid hormones and first-episode psychosis and schizophrenia: A literature review

Annales Academiae Medicae Silesiensis
First-episode psychosis (FEP) and first-episode schizophrenia (FES) are serious psychiatric conditions. Neurosteroids, known to modulate central nervous system function, may play a role in the pathophysiology of these disorders.
Alicja Gładysz, Alicja Dydyna, Martyna Mościcka, Marta Gierlik   +3 more
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