Results 61 to 70 of about 12,871 (217)

Looking for Novelty in an “Old” Receptor: Recent Advances Toward Our Understanding of GABAARs and Their Implications in Receptor Pharmacology

Frontiers in Neuroscience, 2021
Diverse populations of GABAA receptors (GABAARs) throughout the brain mediate fast inhibitory transmission and are modulated by various endogenous ligands and therapeutic drugs.
David Castellano, Ryan David Shepard, Wei Lu   +2 more
doaj   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Analysis of Neurosteroids

YAKUGAKU ZASSHI, 1997
The term neurosteroids applies to those steroids that are both synthesized in the nervous system, either de novo from cholesterol or from steroid hormone precursors, and that accumulate in the nervous system to levels that are at least in part independent of steroidogenic gland secretion rates.
openaire   +3 more sources

Structural basis for GABAA receptor potentiation by neurosteroids

Nature Structural & Molecular Biology, 2017
Type A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of inhibitory neurotransmission in the human brain. Endogenous neurosteroids interact with GABAARs to regulate acute and chronic anxiety and are potent sedative, analgesic ...
Paul S. Miller, Suzanne E. Scott, S. Masiulis, L. de Colibus, E. Pardon, J. Steyaert, A. Aricescu   +6 more
semanticscholar   +1 more source

Potential Neuroendocrine Disruption by Benzodiazepines and Its Impact on Male Fertility

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neuroactive substances have emerged as potent endocrine disruptors affecting male reproductive health through central and peripheral mechanisms. Among these, benzodiazepines, which are widely used for the management of anxiety, insomnia, epilepsy, and neuromuscular disorders, are known as GABA A (gamma‐aminobutyric acid type A) receptor ...
Ana Clara Melo Andrade de Rodrigues, Julia Gonçalves Rodrigues, Marcos de Lucca Moreira Gomes, Fernanda Carolina Ribeiro Dias   +3 more
wiley   +1 more source

Gut microbiota dysbiosis and Long COVID susceptibility in chronic kidney disease

VIEW, EarlyView.
This study investigated gut microbiota dysbiosis and its association with Long COVID susceptibility in 224 hemodialysis patients. We found that 35.3% of patients developed Long COVID, characterized by neurological symptoms and elevated inflammatory markers, accompanied by significant gut microbiota alterations including enriched proinflammatory taxa ...
Meiling Jin, Lijie Ma, Yuqing Yuan, Kaiyi Zhu, Zhaohui Tong, Qianmei Sun   +5 more
wiley   +1 more source

Multidimensional Determinants of Quality of Life in Men With Klinefelter Syndrome: A Narrative Review of Workshop Evidence

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome (KS), typically characterized by a 47, XXY karyotype, is the most common sex chromosomal aneuploidy in males, with a prevalence of approximately one in 600–660 individuals. Despite its frequency, the syndrome remains significantly underdiagnosed, with 50%–75% of affected individuals never receiving a clinical ...
Francesca Allosso, Lucia Digitale Selvaggio, Daniela Pasquali   +2 more
wiley   +1 more source

Zuranolone – synthetic neurosteroid in treatment of mental disorders: narrative review

Frontiers in Psychiatry, 2023
With each passing year, the number of people suffering from mental disorders grows at a disturbing speed. Neuroactive steroids are a new promising group of drugs with the potential for use in many diseases like postpartum depression, postnatal psychosis,
Rafał Marecki, Joanna Kałuska, Agata Kolanek, Dominika Hakało, Napoleon Waszkiewicz   +4 more
doaj   +1 more source

Gold‐standard evidence and best practice guidance for menstrual cycle‐informed clinical care: An overview for clinicians

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives To synthesize current evidence and provide clinically actionable recommendations for integrating menstrual cycle‐related processes—particularly hormone sensitivity, Premenstrual Dysphoric Disorder (PMDD) and Premenstrual Exacerbation (PME)—into psychological assessment, formulation and treatment.
Ellen R. Lambert, Louise N. Nolan, Katja M. Schmalenberger   +2 more
wiley   +1 more source

Vitamin D deficiency in early pregnancy and the risk of developing cerebral palsy: A case–control study

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To investigate whether maternal deficiency of vitamin D in early pregnancy increases the risk of cerebral palsy (CP) in offspring. Method This registry and biobank‐based case–control study consisted of mother–child pairs from Scania, Sweden. Cases (n = 322) were identified from a nationwide CP‐register born between 1995 and 2014.
Ebba Bergman, Lars Rylander, Christian Lindh, Jesse D. Thacher   +3 more
wiley   +1 more source