Analytical Methods for the Determination of Neuroactive Steroids [PDF]
Biomolecules, 2021 Neuroactive steroids are a family of all steroid-based compounds, of both natural and synthetic origin, which can affect the nervous system functions.
Michal Kaleta +2 more
exaly +9 more sources
Neuroactive Steroids: Receptor Interactions and Responses [PDF]
Frontiers in Neurology, 2017 Neuroactive steroids (NASs) are naturally occurring steroids, which are synthesized centrally as de novo from cholesterol and are classified as pregnane, androstane, and sulfated neurosteroids (NSs).
Kald Beshir Tuem, Tesfay Mehari Atey
doaj +5 more sources
Neuroactive steroids in the programming of neurodevelopment: implications of maternal obesity [PDF]
Frontiers in EndocrinologyNeuroactive steroids synthesized within the maternal-placental-fetal unit play a crucial role in fetal neurodevelopment by regulating cell proliferation, migration, and myelination, neurogenesis, gliogenesis, and synaptogenesis, ultimately shaping brain ...
Carmen J. Zamora-Sánchez +6 more
doaj +2 more sources
The Role of Neuroactive Steroids in Analgesia and Anesthesia: An Interesting Comeback? [PDF]
Biomolecules, 2023 Published evidence over the past few decades suggests that general anesthetics could be neurotoxins especially when administered at the extremes of age.
Vesna Jevtovic-Todorovic +1 more
doaj +2 more sources
Role of Neuroactive Steroids in Health and Disease [PDF]
BiomoleculesSteroidogenesis occurs not only in endocrine peripheral glands (i [...]
Roberto Cosimo Melcangi
doaj +2 more sources
Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders [PDF]
LifePregnane neuroactive steroids, notably allopregnanolone and pregnenolone, exhibit efficacy in mitigating inflammatory signals triggered by toll-like receptor (TLR) activation, thus attenuating the production of inflammatory factors.
Irina Balan +5 more
doaj +2 more sources
Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels [PDF]
Cells, 2020 Preemptive management of post-incisional pain remains challenging. Here, we examined the role of preemptive use of neuroactive steroids with activity on low-voltage activated T-type Ca2+ channels (T-channels) and γ-aminobutyric acid A (GABAA) receptors ...
Quy L. Tat +5 more
doaj +2 more sources
Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia [PDF]
Biomolecules, 2021 Evidence from clinical and preclinical studies implicates dysfunction of N-methyl-D-aspartate receptors (NMDARs) in schizophrenia progression and symptoms.
Kristina Holubova +7 more
doaj +2 more sources
Preventing Phosphorylation of the GABAAR β3 Subunit Compromises the Behavioral Effects of Neuroactive Steroids [PDF]
Frontiers in Molecular Neuroscience, 2022 Neuroactive steroids (NASs) have potent anxiolytic, anticonvulsant, sedative, and hypnotic actions, that reflect in part their efficacy as GABAAR positive allosteric modulators (PAM).
Thuy N. Vien +4 more
doaj +2 more sources
Neuroactive steroids and depression in early pregnancy. [PDF]
Psychoneuroendocrinology, 2021 Progesterone (P4) can be metabolized to two general classes of neuroactive steroids (NAS) -those like allopregnanolone (ALLO) and pregnanolone (PA) which are positive allosteric modulators of the Gamma Aminobutyric Acid type A (GABAA) receptor and those like isoallopregnanolone (ISOALLO) and epipregnanolone (EPI) which are negative allosteric ...
Wenzel ES +7 more
europepmc +3 more sources