Results 31 to 40 of about 4,357 (193)

GABAergic neuroactive steroids: a new frontier in bipolar disorders?

Behavioral and Brain Functions, 2012
Neurosteroids are synthesized in the brain and modulate brain excitability. There is increasing evidence of their sedative, anesthetic and antiseizure properties, as well as their influence on mood.
Carta Mauro Giovanni, Bhat Krishna M, Preti Antonio   +2 more
doaj   +1 more source

Neuroactive steroids and the peripheral nervous system : an update [PDF]

, 2015
In the present review we summarize observations to date supporting the concept that neuroactive steroids are synthesized in the peripheral nervous system, regulate the physiology of peripheral nerves and exert notable neuroprotective actions.
G. Cermenati, S. Giatti, Luis Miguel Garcia-Segura, Gaia Cermenati, M. J. Tetel, Silvia Giatti, Donatella Caruso, M. Pesaresi, R.C. Melcangi, Marc J. Tetel, Marzia Pesaresi, Simone Romano, L. M. Garcia Segura, N. Mitro, Roberto C. Melcangi, S. Romano, D. Caruso, Nico Mitro   +17 more
core   +2 more sources

Neuropsychopharmacological properties of neuroactive steroids in depression and anxiety disorders

, 2006
Neuroactive steroids modulate neurotransmission through modulation of specific neurotransmitter receptors such as γ-aminobutyric acid type A (GABAA) receptors.
Eser D., Schule C., Romeo E., Baghai T.C., Di Michele F., Pasini A., Zwanzger P., Padberg F., Rupprecht R.
core   +2 more sources

Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology

, 2001
Besides their binding to cognate intracellular receptors gonadal steroids may also act as functional antagonists at the 5-HT3 receptor. A structure-activity relationship for the actions of a variety of steroids at the 5-HT3 receptor was elaborated that ...
Holsboer F., Lancel M., Rupprecht R., Di Michele F., Hermann B., Strohle A., Lancel M., Romeo E., Holsboer F., Hermann B., Di Michele F., Strohle A., Rupprecht R., ROMEO, ELENA   +7 more
core   +1 more source

Clinical Manifestations, Pathogenesis, Diagnosis and Treatment of Peripheral Neuropathies in Connective Tissue Diseases: More Diverse and Frequent in Different Subtypes than Expected

Diagnostics, 2021
Purpose of review: To discuss and summarize recent findings in peripheral neuropathy (PN) related to connective tissue diseases (CTD) including its prevalence, clinical manifestations, pathogenesis, diagnosis and treatment.
Lei Jin, Yu Liu
doaj   +1 more source

GABA signaling and neuroactive steroids in adrenal medullary chromaffin cells

Frontiers in Cellular Neuroscience, 2016
GABA is produced not only in the brain, but also in endocrine cells by the two isoforms of glutamic acid decarboxylase (GAD), GAD65 and GAD67. In rat adrenal medullary chromaffin cells only GAD67 is expressed, and GABA is stored in large dense core ...
Keita eHarada, Hidetada eMatsuoka, Hiroaki eFujiwara, Yoichi eUeta, Yuchio eYanagawa, Masumi eInoue   +5 more
doaj   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Neuroactive steroids and addictions [PDF]

, 2013
Neuroactive steroids are a group of steroid hormones which act non-genomically to influence the neuron excitability of neuronal synapses. Addictive substances can interfere with the synthesis of neuroactive steroids through many mechanisms, affecting ...
Jandíková, Hana
core  

Altered Steroidome in Women with Gestational Diabetes Mellitus: Focus on Neuroactive and Immunomodulatory Steroids from the 24th Week of Pregnancy to Labor

Biomolecules, 2021
Gestational diabetes mellitus (GDM) is a complication in pregnancy, but studies focused on the steroidome in patients with GDM are not available in the public domain.
Leona Ondřejíková, Antonín Pařízek, Patrik Šimják, Daniela Vejražková, Marta Velíková, Kateřina Anderlová, Michala Vosátková, Hana Krejčí, Michal Koucký, Radmila Kancheva, Michaela Dušková, Markéta Vaňková, Josef Bulant, Martin Hill   +13 more
doaj   +1 more source