Results 1 to 10 of about 4,428 (136)

Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease

Neurobiology of Stress, 2020
For several years, research from around the world has suggested that the neuroactive steroid (3α,5α)-3-hydroxypregnan-20-one (allopregnanolone) may have therapeutic potential for treatment of various stress-related diseases including post-traumatic ...
Giorgia Boero, Patrizia Porcu, A Leslie Morrow   +2 more
exaly   +3 more sources

Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective

Neurobiology of Stress, 2020
Allopregnanolone is synthesized in the central nervous system either de novo from cholesterol or from steroid hormone precursors like progesterone and pregnenolone. Over the past 30 years, direct and rapid, non-genomic actions of allopregnanolone and its
Steven M Paul, Graziano Pinna
exaly   +3 more sources

Allopregnanolone relieves paclitaxel induced mechanical hypersensitivity via inhibiting spinal cord PGE2-EP2 mediated microglia-neuron signaling [PDF]

IBRO Neuroscience Reports
Chemotherapy-induced neuropathic pain (CINP) is a serious adverse effect of commonly used chemotherapeutics. Neurosteroid allopregnanolone is suggested to modulate the expression of various receptors or enzymes that involved in pain perception ...
Kunlin Guo, Lei Gao, Ping Li, Shanwu Feng, Liping Zhao, Xian Wang   +5 more
doaj   +2 more sources

Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage

Frontiers in Pharmacology, 2021
Mesolimbic dopamine transmission is dysregulated in multiple psychiatric disorders, including addiction. Previous studies found that the endogenous GABAergic steroid (3α,5α)-3-hydroxy-5-pregnan-20-one (allopregnanolone) modulates dopamine levels in the ...
Ana Paula S. Dornellas, Ana Paula S. Dornellas, Giovana C. Macedo, Giovana C. Macedo, Minna H. McFarland, Alexander Gómez-A, Todd K. O’Buckley, Claudio Da Cunha, A. Leslie Morrow, A. Leslie Morrow, A. Leslie Morrow, Donita L. Robinson, Donita L. Robinson   +12 more
doaj   +1 more source

Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?

Canadian Journal of Gastroenterology and Hepatology, 2022
Background and Aims. A third of patients with primary biliary cholangitis (PBC) experience poorly understood cognitive symptoms, with a significant impact on quality of life (QOL), and no effective medical treatment.
Aaron Wetten, Laura Ogle, George Mells, Vinod S. Hegade, Laura Jopson, Margaret Corrigan, Jeremy Palmer, Maja Johansson, Torbjörn Bäckström, Magnus Doverskog, David E. J. Jones, Jessica K. Dyson   +11 more
doaj   +1 more source

Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: Implication for drug abuse

Neurobiology of Stress, 2020
Several studies have highlighted the role that early postnatal levels of allopregnanolone play in the development of the CNS and adult behavior. Changes in allopregnanolone levels related to stress have been observed during early postnatal periods, and ...
Iris Bartolomé, Anna Llidó, Sònia Darbra, Marc Pallarès   +3 more
doaj   +1 more source

Inhibition of human macrophage activation via pregnane neurosteroid interactions with toll-like receptors: Sex differences and structural requirements

Frontiers in Immunology, 2022
We recently discovered that (3α,5α)3-hydroxypregnan-20-one (allopregnanolone) inhibits pro-inflammatory toll-like receptor (TLR) activation and cytokine/chemokine production in mouse macrophage RAW264.7 cells.
Irina Balan, Laure Aurelian, Kimberly S. Williams, Brian Campbell, Rick B. Meeker, A. Leslie Morrow   +5 more
doaj   +1 more source

The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study

Endocrine Connections, 2017
Objective: Large weight gain during pregnancy is a risk factor for complications for mother and fetus. Hunger and satiety are regulated in the hypothalamus, where the gamma-amino-butyric acid system (GABA) has an important role.
Anette Lundqvist, Herbert Sandström, Torbjörn Bäckström   +2 more
doaj   +1 more source

Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease. [PDF]

PLoS ONE, 2012
Restorative/protective therapies to restore dopamine neurons in the substantia nigra pars compacta (SNpc) are greatly needed to effectively change the debilitating course of Parkinson's disease.
Samuel O Adeosun, Xu Hou, Yun Jiao, Baoying Zheng, Sherry Henry, Rosanne Hill, Zhi He, Amar Pani, Patrick Kyle, Xiaoming Ou, Thomas Mosley, Jerry M Farley, Craig Stockmeier, Ian Paul, Steven Bigler, Roberta Diaz Brinton, Richard Smeyne, Jun Ming Wang   +17 more
doaj   +1 more source

Trajectories of Allopregnanolone and Allopregnanolone to Progesterone Ratio across the Six Subphases of Menstrual Cycle

Biomolecules, 2023
Background: Allopregnanolone is one of the most studied neuroactive steroids; yet, despite its relevance to neuropsychiatric research, it is not known how it, as well as its ratio to progesterone, varies across all six subphases of the menstrual cycle ...
Ajna Hamidovic, John Davis, Fatimata Soumare, Avisek Datta, Aamina Naveed   +4 more
doaj   +1 more source