Results 31 to 40 of about 4,624 (175)

Anti-apoptotic Actions of Allopregnanolone and Ganaxolone Mediated Through Membrane Progesterone Receptors (PAQRs) in Neuronal Cells

Frontiers in Endocrinology, 2020
The neurosteroids progesterone and allopregnanolone regulate numerous neuroprotective functions in neural tissues including inhibition of epileptic seizures and cell death.
Peter Thomas, Yefei Pang
doaj   +1 more source

The Allopregnanolone Response to Acute Stress in Females: Preclinical and Clinical Studies

Biomolecules, 2022
The neuroactive steroid allopregnanolone ((3α,5α)-3-hydroxypregnan-20-one or 3α,5α-THP) plays a key role in the response to stress, by normalizing hypothalamic-pituitary-adrenal (HPA) axis function to restore homeostasis. Most studies have been conducted
Maria Giuseppina Pisu, Luca Concas, Carlotta Siddi, Mariangela Serra, Patrizia Porcu   +4 more
doaj   +1 more source

Progesterone Exerts a Neuromodulatory Effect on Turning Behavior of Hemiparkinsonian Male Rats: Expression of 3α-Hydroxysteroid Oxidoreductase and Allopregnanolone as Suggestive of GABAA Receptors Involvement

Parkinson's Disease, 2015
There is a growing amount of evidence for a neuroprotective role of progesterone and its neuroactive metabolite, allopregnanolone, in animal models of neurodegenerative diseases.
Roberto Yunes, Sebastián Casas, Eliana Gaglio, Ricardo Cabrera   +3 more
doaj   +1 more source

The fetal brain: role of progesterone and allopregnanolone [PDF]

Hormone Molecular Biology and Clinical Investigation, 2016
Abstract Progesterone and allopregnanolone have crucial and different roles in brain development, function and recovery after injury. Pregnancy is characterized by an increased synthesis of progesterone and its neuro-active metabolites by the placenta, maternal and fetal brain.
Nicola, Pluchino, Marinella, Russo, Andrea R, Genazzani   +2 more
openaire   +2 more sources

Allopregnanolone alters follicular and luteal dynamics during the estrous cycle

Reproductive Biology and Endocrinology, 2018
Background Allopregnanolone is a neurosteroid synthesized in the central nervous system independently of steroidogenic glands; it influences sexual behavior and anxiety.
Joana Antonela Asensio, Antonella Rosario Ramona Cáceres, Laura Tatiana Pelegrina, María de los Ángeles Sanhueza, Leopoldina Scotti, Fernanda Parborell, Myriam Raquel Laconi   +6 more
doaj   +1 more source

Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone

Molecular Pain, 2022
Orofacial pain disorders are predominately experienced by women. Progesterone, a major ovarian hormone, is neuroprotective and antinociceptive. We recently reported that progesterone attenuates estrogen-exacerbated orofacial pain behaviors, yet it ...
Rebecca S Hornung, Namrata GR Raut, Daisy J Cantu, Lauren M Lockhart, Dayna L Averitt   +4 more
doaj   +1 more source

Tolerance to allopregnanolone with focus on the GABA‐A receptor [PDF]

British Journal of Pharmacology, 2010
Many studies have suggested a relationship between stress, sex steroids, and negative mental and mood changes in humans. The progesterone metabolite allopregnanolone is a potent endogenous ligand of the γ‐amino butyric acid –A (GABA‐A) receptor, and the most discussed neuroactive steroid.
Sahruh, Turkmen, Torbjorn, Backstrom, Goran, Wahlstrom, Lotta, Andreen, Inga-Maj, Johansson   +4 more
openaire   +2 more sources

Allopregnanolone relieves paclitaxel induced mechanical hypersensitivity via inhibiting spinal cord PGE2-EP2 mediated microglia-neuron signaling

IBRO Neuroscience Reports
Chemotherapy-induced neuropathic pain (CINP) is a serious adverse effect of commonly used chemotherapeutics. Neurosteroid allopregnanolone is suggested to modulate the expression of various receptors or enzymes that involved in pain perception ...
Kunlin Guo, Lei Gao, Ping Li, Shanwu Feng, Liping Zhao, Xian Wang   +5 more
doaj   +1 more source

Negative Association Between Allopregnanolone and Cerebral Serotonin Transporter Binding in Healthy Women of Fertile Age

Frontiers in Psychology, 2019
Allopregnanolone is a metabolite of the sex hormone progesterone, with suggested relevance for female mood disorders. While allopregnanolone and serotonin are known to influence psychological well-being, the molecular and psychological specifics of their
Inger Sundström Poromaa, Erika Comasco, Torbjörn Bäckström, Marie Bixo, Peter Jensen, Vibe G. Frokjaer, Vibe G. Frokjaer   +6 more
doaj   +1 more source

Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction Allopregnanolone is an endogenous neurosteroid with the potential to be a novel regenerative therapeutic for Alzheimer's disease (AD). Foundations of mechanistic understanding and well‐established preclinical safety efficacy make it a viable
Gerson D. Hernandez, Christine M. Solinsky, Wendy J. Mack, Naoko Kono, Kathleen E. Rodgers, Chun‐Yi Wu, Ana R. Mollo, Claudia M. Lopez, Sonia Pawluczyk, Gerhard Bauer, Dawn Matthews, Yonggang Shi, Meng Law, Michael A. Rogawski, Lon S. Schneider, Roberta D. Brinton   +15 more
doaj   +1 more source