Results 31 to 40 of about 6,010 (206)
The role of allopregnanolone in depressive-like behaviors: Focus on neurotrophic proteins
Neurobiology of Stress, 2020 Allopregnanolone (3α,5α-tetrahydroprogesterone; pharmaceutical formulation: brexanolone) is a neurosteroid that has recently been approved for the treatment of postpartum depression, promising to fill part of a long-lasting gap in the effectiveness of ...
Felipe Borges Almeida +2 more
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Allopregnanolone and neuroinflammation: a focus on multiple sclerosis [PDF]
Frontiers in Cellular Neuroscience, 2014 The progesterone derivative allopregnanolone (ALLO) is one of the most widely studied compounds among neurosteroids. Through interactions with GABA-A receptors expressed by neurons and glial cells, ALLO has been shown to affect diverse aspects of neural cell physiology, including cell proliferation and survival, migration, and gene expression.
Noorbakhsh, Farshid +2 more
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Neuroregenerative Mechanisms of Allopregnanolone in Alzheimer’s Disease [PDF]
Frontiers in Endocrinology, 2012 The proliferative pool and regenerative potential of neural stem cells diminishes with age, a phenomenon that may be exacerbated in prodromal and mild Alzheimer's disease (AD) brains. In parallel, the neuroactive progesterone metabolite, allopregnanolone (APα), along with a host of other factors, is decreased in the AD brain.
Irwin, Ronald W. +3 more
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Frontiers in Cellular Neuroscience, 2014 Neurosteroids are cholesterol-based hormones that can be produced in the brain, independent of secretion from peripheral endocrine glands, such as the gonads and adrenals.
Cheryl A Frye +2 more
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Allopregnanolone and neurogenesis in the nigrostriatal tract [PDF]
Frontiers in Cellular Neuroscience, 2014 Reinstalling the neurobiological circuits to effectively change the debilitating course of neurodegenerative diseases is of utmost importance. This reinstallation requires generation of new cells which are able to differentiate into specific types of neurons and modification of the local environment suitable for integration of these new neurons into ...
openaire +3 more sources
Biology of Sex Differences, 2022 Highlights Progesterone has sex-dependent effects on smoking measures in individuals with Tobacco Use Disorder. Higher conversion of progesterone to allopregnanolone (as indicated by the allopregnanolone:progesterone ratio) was associated with lower ...
Andrew M. Novick +10 more
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Frontiers in Endocrinology, 2020 The neurosteroids progesterone and allopregnanolone regulate numerous neuroprotective functions in neural tissues including inhibition of epileptic seizures and cell death.
Peter Thomas, Yefei Pang
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Frontiers in Behavioral Neuroscience, 2022 Systemic injections of the flavonoid chrysin (5,7-dihydroxyflavone) exert anxiolytic-like effects in ovariectomised and cycling female rats through actions on gamma-aminobutyric acid-A (GABAA) receptors; however, it is unknown if chrysin directly acts on
Juan Francisco Rodríguez-Landa +8 more
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Journal of Pharmacological Sciences, 2018 The neurosteroid allopregnanolone has potent analgesic effects, and its potential use for neuropathic pain is supported by recent reports. However, the analgesic mechanisms are obscure.
Takafumi Horishita +9 more
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Structural insights into opposing actions of neurosteroids on GABAA receptors
Nature Communications, 2023 γ-Aminobutyric acid type A (GABAA) receptors mediate fast inhibitory signaling in the brain and are targets of numerous drugs and endogenous neurosteroids.
Dagimhiwat H. Legesse +7 more
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