Results 51 to 60 of about 4,624 (175)

Indications and Efficacy of Progestogen‐Monotherapy as Menopause Hormone Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Menopausal hormone therapy (MHT) remains the most effective treatment for vasomotor symptoms (VMS) and other manifestations of menopause; however, its use is limited in women with contraindications to oestrogen. Progestogen monotherapy, though historically underutilized, represents a viable alternative in this population. This narrative review
Chloe Thomas, Olivia Carere, Lauren Clarfield, Michelle Jacobson   +3 more
wiley   +1 more source

Allopregnanolone-based treatments for postpartum depression: Why/how do they work?

Neurobiology of Stress, 2019
Recent FDA approval of an allopregnanolone-based treatment specifically for postpartum depression, brexanolone, now commercially called Zulresso®, is an exciting development for patients and families impacted by postpartum depression and allows us to ...
Najah Walton, Jamie Maguire
doaj   +1 more source

Gold‐standard evidence and best practice guidance for menstrual cycle‐informed clinical care: An overview for clinicians

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives To synthesize current evidence and provide clinically actionable recommendations for integrating menstrual cycle‐related processes—particularly hormone sensitivity, Premenstrual Dysphoric Disorder (PMDD) and Premenstrual Exacerbation (PME)—into psychological assessment, formulation and treatment.
Ellen R. Lambert, Louise N. Nolan, Katja M. Schmalenberger   +2 more
wiley   +1 more source

New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study

Arthritis Care &Research, Volume 78, Issue 9, Page 1247-1255, September 2026.
Objective Traumatic life events are hypothesized to be triggers for the onset of fibromyalgia. Posttraumatic stress disorder (PTSD) is a common comorbidity of fibromyalgia. However, limited prospective data are available on the development of fibromyalgia after exposure to high‐magnitude stress.
Jay B. Higgs, Willie J. Hale, Casey L. Straud, Jim Mintz, Stacey Young‐McCaughan, Kimberly D. Gomes, Chelsea J. Sterne, Katrina M. Lawrence‐Wolff, Alan J. Bartholomew, Kevin M. Kelly, Douglas M. Maurer, Catherine Vriend, Brett T. Litz, Douglas E. Williamson, Alan L. Peterson, for the STRONG STAR Consortium   +15 more
wiley   +1 more source

Neurosteroid involvement in threatened preterm labour

Endocrinology, Diabetes & Metabolism, 2021
Introduction The neurosteroid allopregnanolone modulates oxytocin expression in the brain, and its effects arise from its action on the GABAA receptor. Whether neurosteroid levels and the function of the GABAA receptor are involved in the risk of preterm
Sahruh Turkmen, Torbjörn Bäckström, Yvonne Kangas Flodin, Marie Bixo   +3 more
doaj   +1 more source

Periestropause enhances hypoxia‐induced panic and microglial remodelling without altering respiratory control

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Perimenopause is characterised by irregular reproductive cycles and hormonal fluctuations, notably decreased estradiol (E2), which are linked to increased susceptibility to panic disorder and neuroinflammation. We examined whether panic‐related respiratory and behavioural responses to respiratory challenges vary across reproductive stages ...
Angela Cristina Nicola, Luana Tenório‐Lopes, Luis Gustavo A. Patrone, Mariana Bernardes‐Ribeiro, Heloisa H. Vilela‐Costa, Daniele Gandra, Ana Clara Campideli‐Santana, Raphael E. Szawka, Kênia C. Bícego, Rita Cássia M. Dornelles, Luciane H. Gargaglioni   +10 more
wiley   +1 more source

Age and sex effects of a validated LC-MS/MS method for the simultaneous quantification of testosterone, allopregnanolone, and its isomers in human serum

Scientific Reports
Despite the great relevance of the neurosteroid allopregnanolone and related isomers to various health conditions, quantification typically involves immunoassay, which suffers from serious issues with cross-reactivity of closely related molecules.
Khalisa Amir Hamzah, Leisa-Maree Toms, Nathaniel Kucharski, Julia Orr, Peter Hobson, David S. Nichols, Luke J. Ney   +6 more
doaj   +1 more source

Grief as a neuroendocrine transition: Insights from perinatal loss

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Grief is an all‐encompassing human experience that reverberates across mind, brain, and body. Historically, the scientific study of grief has been rooted primarily in psychological frameworks. Pioneering work has begun to elucidate how attachment loss is encoded not only psychologically but also biologically, and this may be particularly ...
Clare Killikelly, Eva‐Maria Stelzer, Rita T. Amiel Castro   +2 more
wiley   +1 more source

Allopregnanolone: Regenerative therapeutic to restore neurological health

Neurobiology of Stress, 2022
Chronic stress has been proposed as a driver of altered brain structure and function, including the pathogenesis of neurodegenerative diseases and a driver of disease progression. A key outcome of stress in the brain is structural remodeling of neural architecture, which may be a sign of successful adaptation, whereas persistence of these changes when ...
Gerson D. Hernandez, Roberta D. Brinton
openaire   +3 more sources

The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling

Nature Communications, 2022
Early-life adversity (ELA) increases the likelihood of neuropsychiatric diagnoses, which are more prevalent in women than men. Since changes in reproductive hormone levels can also increase the probability of anxiety disorders in women, we examined the ...
Blake J. Laham, Sahana S. Murthy, Monica Hanani, Mona Clappier, Sydney Boyer, Betsy Vasquez, Elizabeth Gould   +6 more
doaj   +1 more source