Results 51 to 60 of about 6,010 (206)

Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

eLife, 2020
This study examines how site-specific binding to three identified neurosteroid-binding sites in the α1β3 GABAA receptor (GABAAR) contributes to neurosteroid allosteric modulation. We found that the potentiating neurosteroid, allopregnanolone, but not its
Yusuke Sugasawa, Wayland WL Cheng, John R Bracamontes, Zi-Wei Chen, Lei Wang, Allison L Germann, Spencer R Pierce, Thomas C Senneff, Kathiresan Krishnan, David E Reichert, Douglas F Covey, Gustav Akk, Alex S Evers   +12 more
doaj   +1 more source

High serum allopregnanolone levels in girls with precocious puberty [PDF]

, 2002
Allopregnanolone, a circulating neuroactive steroid hormone, is involved in the modulation of behavioral functions, stress, and the neuroendocrine axis.
S. Forese, BERNASCONI, Sergio, F. Petraglia, COBELLIS, Luigi, PETRAGLIA, F., M. Luisi, LUISI, S., L. Cobellis, S. Bernasconi, PETRAGLIA F, FORESE, S., IUGHETTI, Lorenzo, PREDIERI, B., LUISI, M., BERNASCONI, S., IUGHETTI, L., PREDIERI B, BERNASCONI S., S. Luisi, COBELLIS L, COBELLIS, L., PREDIERI, Barbara, LUISI M, LUISI S, IUGHETTI L, FORESE S   +25 more
core   +1 more source

Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience [version 1; peer review: 4 approved]

F1000Research, 2019
The GABAergic deficit hypothesis of depression states that a deficit of GABAergic transmission in defined neural circuits is causal for depression. Conversely, an enhancement of GABA transmission, including that triggered by selective serotonin reuptake ...
Bernhard Lüscher, Hanns Möhler
doaj   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Allopregnanolone involvement in feeding regulation, overeating and obesity [PDF]

, 2018
Obesity is strongly associated with ill health, primarily caused by consumption of excessive calories, and promoted (inter alia) by gamma-amino-butyric-acid (GABA) stimulating food intake by activating GABA(A) receptors (primarily with alpha 3 and alpha ...
Johansson, Maja, M. Johansson, M. Löfgren, Turkmen, Sahruh,, Lundqvist, Anette, Jaukkuri, L., Löfgren, Mats,, Ragagnin, Gianna, E. Holmberg, Jaukkuri, L.,, Malinina, E.,, Sjöstedt, J., Johansson, Maja,, Turkmen, Sahruh, Bäckström, Torbjörn, Ragagnin, Gianna,, Bäckström, Torbjörn,, Bixo, Marie, A. Lundqvist, Malinina, E., Holmberg, Ellinor,, T. Bäckström, Holmberg, Ellinor, J. Sjöstedt, Löfgren, Mats, E. Malinina, L. Jaukkuri, S. Turkmen, G. Ragagnin, Bixo, Marie,, M. Bixo, Lundqvist, Anette,, Sjöstedt, J.,   +32 more
core   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Allopregnanolone in mood disorders: Mechanism and therapeutic development

Pharmacological Research, 2021
The neuroactive steroid allopregnanolone (ALLO) is an endogenous positive allosteric modulator of GABA type A receptor (GABAAR), and the down-regulation of its biosynthesis have been attributed to the development of mood disorders, such as depression, anxiety and post-traumatic stress disorder (PTSD). ALLO mediated depression/anxiety involves GABAergic
Shiyi Chen, Lijuan Gao, Xiaoyu Li, Yiping Ye   +3 more
openaire   +2 more sources

Gut microbiota dysbiosis and Long COVID susceptibility in chronic kidney disease

VIEW, EarlyView.
This study investigated gut microbiota dysbiosis and its association with Long COVID susceptibility in 224 hemodialysis patients. We found that 35.3% of patients developed Long COVID, characterized by neurological symptoms and elevated inflammatory markers, accompanied by significant gut microbiota alterations including enriched proinflammatory taxa ...
Meiling Jin, Lijie Ma, Yuqing Yuan, Kaiyi Zhu, Zhaohui Tong, Qianmei Sun   +5 more
wiley   +1 more source