Results 61 to 70 of about 6,010 (206)

Inhibition of carbachol by allopregnanolone. [PDF]

, 2019
The inhibitory dose-response curves for allopregnanolone on carbachol (Cch)-stimulated current, represented as a percentage of the maximal response to Cch. The data are represented as mean ± SEM (n = 5).
Joseph V. Martin (7465346), Eric A. Klein (7465343), Steven X. Moffett (7465340), Grace Brannigan (160636)   +3 more
core   +1 more source

Allopregnanolone-based treatments for postpartum depression: Why/how do they work?

Neurobiology of Stress, 2019
Recent FDA approval of an allopregnanolone-based treatment specifically for postpartum depression, brexanolone, now commercially called Zulresso®, is an exciting development for patients and families impacted by postpartum depression and allows us to ...
Najah Walton, Jamie Maguire
doaj   +1 more source

Prenatal 17‐Alpha‐Hydroxyprogesterone Caproate Exposure in Twins and Childhood Outcomes: 14‐Year Follow‐Up of a Randomised Trial

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Long‐term child outcomes after intra‐uterine exposure to 17‐alpha‐hydroxyprogesterone caproate (17‐OHPC) versus placebo. Design Follow‐up of the AMPHIA randomised controlled trial assessing neonatal outcomes after weekly 17‐OHPC injections compared to placebo in multiple pregnancies. Setting Multicentre. Population or Sample Children
Emilie V. J. van Limburg Stirum, Marjon A. de Boer, A. C. J. Ravelli, Rik van Eekelen, Aleid G. Leemhuis, Martijn J. J. Finken, Cornelieke S. H. Aarnoudse‐Moens, Anneloes L. van Baar, Noor E. Simons, Rebecca C. Painter, Arianne C. Lim, Ben W. Mol, Eva Pajkrt, Martijn A. Oudijk, Janneke van 't Hooft   +14 more
wiley   +1 more source

Allopregnanolone, birth experience and postpartum depression in healthy pregnant women [PDF]

, 2023
There is contrasting evidence to suggest that salivary allopregnanolone in pregnancy affects depressive symptoms in the postpartum, as well as if and how this potential relationship is mediated by the birth experience of the women.
Maria Grötsch, Ulrike Ehlert, Celine von Dombrowski   +2 more
core   +1 more source

Indications and Efficacy of Progestogen‐Monotherapy as Menopause Hormone Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Menopausal hormone therapy (MHT) remains the most effective treatment for vasomotor symptoms (VMS) and other manifestations of menopause; however, its use is limited in women with contraindications to oestrogen. Progestogen monotherapy, though historically underutilized, represents a viable alternative in this population. This narrative review
Chloe Thomas, Olivia Carere, Lauren Clarfield, Michelle Jacobson   +3 more
wiley   +1 more source

Allopregnanolone concentrations and premenstrual syndrome. [PDF]

, 2000
OBJECTIVE: To evaluate basal allopregnanolone and progesterone in both phases of the menstrual cycle in women suffering from premenstrual syndrome (PMS) and their response to a GnRH test.
GENAZZANI, ANDREA, Bernardi F, Luisi S, Monteleone P, Genazzani A., Luisi M, Petraglia F, Tonetti A   +7 more
core  

Tolerance development to Morris water maze test impairments induced by acute allopregnanolone [PDF]

, 2006
The progesterone metabolite allopregnanolone, like benzodiazepines, reduces learning and impairs memory in rats. Both substances act as GABA agonists at the GABA-A receptor and impair the performance in the Morris water maze test.
Löfgren, Magnus,, Bäckström, Torbjörn,, Johansson, Inga-Maj,, Türkmen, Sahruh,, Birzniece, Vita,   +4 more
core   +1 more source

Gold‐standard evidence and best practice guidance for menstrual cycle‐informed clinical care: An overview for clinicians

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives To synthesize current evidence and provide clinically actionable recommendations for integrating menstrual cycle‐related processes—particularly hormone sensitivity, Premenstrual Dysphoric Disorder (PMDD) and Premenstrual Exacerbation (PME)—into psychological assessment, formulation and treatment.
Ellen R. Lambert, Louise N. Nolan, Katja M. Schmalenberger   +2 more
wiley   +1 more source

Age and sex effects of a validated LC-MS/MS method for the simultaneous quantification of testosterone, allopregnanolone, and its isomers in human serum

Scientific Reports
Despite the great relevance of the neurosteroid allopregnanolone and related isomers to various health conditions, quantification typically involves immunoassay, which suffers from serious issues with cross-reactivity of closely related molecules.
Khalisa Amir Hamzah, Leisa-Maree Toms, Nathaniel Kucharski, Julia Orr, Peter Hobson, David S. Nichols, Luke J. Ney   +6 more
doaj   +1 more source

Neurosteroid involvement in threatened preterm labour

Endocrinology, Diabetes & Metabolism, 2021
Introduction The neurosteroid allopregnanolone modulates oxytocin expression in the brain, and its effects arise from its action on the GABAA receptor. Whether neurosteroid levels and the function of the GABAA receptor are involved in the risk of preterm
Sahruh Turkmen, Torbjörn Bäckström, Yvonne Kangas Flodin, Marie Bixo   +3 more
doaj   +1 more source