Zuranolone – synthetic neurosteroid in treatment of mental disorders: narrative review
Frontiers in Psychiatry, 2023 With each passing year, the number of people suffering from mental disorders grows at a disturbing speed. Neuroactive steroids are a new promising group of drugs with the potential for use in many diseases like postpartum depression, postnatal psychosis,
Napoleon Waszkiewicz +1 more
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Neurosteroid withdrawal disrupts GABAergic system development in human cortical organoids: implications for preterm birth [PDF]
Frontiers in Cellular NeurosciencePreterm birth substantially elevates the risk of neurological and cognitive disorders. Recent evidence suggests that the abrupt loss of placental support, particularly the cessation of neurotrophic and neuroprotective hormones, alters neurodevelopmental ...
Helene Lacaille +4 more
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Isoallopregnanolone Inhibits Estrus Cycle-Dependent Aggressive Behavior
Biomolecules, 2023 Among female rats, some individuals show estrus cycle-dependent irritability/aggressive behaviors, and these individual rats may be used as a model for premenstrual dysphoric disorder (PMDD). We wanted to investigate if these behaviors are related to the
Torbjörn Bäckström +7 more
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Biomolecules, 2023 Objectives In Vitro: To study the effects of GR3027 (golexanolone) on neurosteroid-induced GABA-mediated current responses under physiological GABAergic conditions with recombinant human α5β3γ2L and α1β2γ2L GABAA receptors expressed in human embryonic ...
Sara K. S. Bengtsson +7 more
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The non-benzodiazepine anxiolytic drug etifoxine causes a rapid, receptor-independent stimulation of neurosteroid biosynthesis. [PDF]
PLoS ONE, 2015 Neurosteroids can modulate the activity of the GABAA receptors, and thus affect anxiety-like behaviors. The non-benzodiazepine anxiolytic compound etifoxine has been shown to increase neurosteroid concentrations in brain tissue but the mode of action of ...
Jean Luc do Rego +2 more
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Neurobiology of Stress, 2020 Cognitive dysfunction, dementia and Alzheimer's disease (AD) are increasing as the population worldwide ages. Therapeutics for these conditions is an unmet need.
S.K.S. Bengtsson +6 more
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Brain-Derived Estrogen and Neurological Disorders
Biology, 2022 Astrocytes and neurons in the male and female brains produce the neurosteroid brain-derived 17β-estradiol (BDE2) from androgen precursors. In this review, we discuss evidence that suggest BDE2 has a role in a number of neurological conditions, such as ...
Darrell W. Brann +7 more
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Site-specific effects of neurosteroids on GABAA receptor activation and desensitization
eLife, 2020 This study examines how site-specific binding to three identified neurosteroid-binding sites in the α1β3 GABAA receptor (GABAAR) contributes to neurosteroid allosteric modulation. We found that the potentiating neurosteroid, allopregnanolone, but not its
Yusuke Sugasawa +12 more
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Development and Characterization of Inducible Astrocyte-Specific Aromatase Knockout Mice
Biology, 2023 17β-estradiol (E2) is produced in the brain as a neurosteroid, in addition to being an endocrine signal in the periphery. The current animal models for studying brain-derived E2 include global and conditional non-inducible knockout mouse models.
Jing Wang +6 more
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The Ability of Pregnenolone in Proliferation of Mouse Neural Stem Cells and Reduction of Inflammatory and Oxidant Markers after Induction of Inflammation with Lipopolysaccharide in Vitro [PDF]
Armaghane Danesh Bimonthly Journal, 2023 Background & aim: Pregnenolone acts as a precursor to other steroid hormones and exerts its effect as an anti-inflammatory molecule to maintain immune homeostasis in various inflammatory conditions. In these diseases, a decrease in the level ofP has been
K Negintaji +3 more
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