Results 31 to 40 of about 5,061 (119)

Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model

Frontiers in Molecular Neuroscience, 2019
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. A reduction in neuronal inhibition mediated by γ-aminobutyric acid type A receptors (GABAARs) has been implicated in the pathophysiology of FXS.
Amit Modgil, Thuy N. Vien, Michael A. Ackley, James J. Doherty, Stephen J. Moss, Stephen J. Moss, Paul A. Davies   +6 more
doaj   +1 more source

Pharmacological and Biophysical Characteristics of Picrotoxin-Resistant, δSubunit-Containing GABAA Receptors

Frontiers in Synaptic Neuroscience, 2021
GABAA receptors (GABAARs) play a crucial role in inhibition in the central nervous system. GABAARs containing the δ subunit mediate tonic inhibition, have distinctive pharmacological properties and are associated with disorders of the nervous system.
Hong-Jin Shu, Xinguo Lu, John Bracamontes, Joe Henry Steinbach, Joe Henry Steinbach, Charles F. Zorumski, Charles F. Zorumski, Charles F. Zorumski, Steven Mennerick, Steven Mennerick, Steven Mennerick   +10 more
doaj   +1 more source

Novel receptor targets for production and action of allopregnanolone in the central nervous system: a focus on pregnane xenobiotic receptor

Frontiers in Cellular Neuroscience, 2014
Neurosteroids are cholesterol-based hormones that can be produced in the brain, independent of secretion from peripheral endocrine glands, such as the gonads and adrenals.
Cheryl A Frye, Carolyn J Koonce, Alicia A Walf   +2 more
doaj   +1 more source

Dehydroepiandrosterone (DHEA) increases undirected singing behavior and alters dopaminergic regulation of undirected song in non-breeding male European starlings (Sturnus vulgaris)

Frontiers in Endocrinology, 2023
IntroductionIt has been proposed that in species that defend territories across multiple life history stages, brain metabolism of adrenal dehydroepiandrosterone (DHEA) regulates aggressive behavior at times when gonadal androgen synthesis is low (i.e ...
Sarah Heimovics, Nathan Rubin, Morgan Ford   +2 more
doaj   +1 more source

The brain of teleost fish, a source and a target of sexual steroids

Frontiers in Neuroscience, 2011
Neurosteroids are defined as steroids de novo synthesized in the central nervous system. While the production of neurosteroids is well documented in mammals or amphibians, there is little information in teleosts, the largest group of fish.
Nicolas eDiotel, Jean-Luc eDo-Rego, Isabelle eAnglade, Colette eVaillant, Elisabeth ePellegrini, Hubert eVaudry, Olivier eKah   +6 more
doaj   +1 more source

A narrative review of potential neural repair poststroke: Decoction of Chinese angelica and peony in regulating microglia polarization through the neurosteroid pathway

Brain Circulation
Ischemic stroke is a major global health crisis, characterized by high morbidity and mortality rates. Although there have been significant advancements in treating the acute phase of this condition, there remains a pressing need for effective treatments ...
Linhui Qin, Peter Kamash, Yong Yang, Yuchuan Ding, Changhong Ren   +4 more
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Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders

Life
Pregnane neuroactive steroids, notably allopregnanolone and pregnenolone, exhibit efficacy in mitigating inflammatory signals triggered by toll-like receptor (TLR) activation, thus attenuating the production of inflammatory factors.
Irina Balan, Giorgia Boero, Samantha Lucenell Chéry, Minna H. McFarland, Alejandro G. Lopez, A. Leslie Morrow   +5 more
doaj   +1 more source

DEHYDROEPIANDROSTERONE BIOSYNTHESIS, ROLE AND MECHANISM OF ACTION IN THE DEVELOPING NEURAL TUBE.

Frontiers in Endocrinology, 2012
Dehydroepiandrosterone (DHEA) is synthesized from cholesterol by activity of P450scc and P450c17, enzymes that we previously characterized in the developing nervous system.
mark eGaldo, Christelle S Fiore, Jennifer eGregonis, Nathalie A Compagnone, Nathalie A Compagnone   +4 more
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Pineal Neurosteroids: Biosynthesis and Physiological Functions

Frontiers in Endocrinology, 2020
Similar to the adrenal glands, gonads, and placenta, vertebrate brains also produce various steroids, which are known as “neurosteroids.” Neurosteroids are mainly synthesized in the hippocampus, hypothalamus, and cerebellum; however, it has recently been
Shogo Haraguchi, Kazuyoshi Tsutsui
doaj   +1 more source

Allopregnanolone and Neuroinflammation: a Focus on Multiple Sclerosis

Frontiers in Cellular Neuroscience, 2014
The progesterone derivative, allopregnanolone (ALLO), is one of the most widely studied compounds among neurosteroids. Through interactions with GABA-A receptors expressed by neurons and glial cells, ALLO has been shown to affect diverse aspects of ...
Farshid eNoorbakhsh, Glen B Baker, Christopher ePower   +2 more
doaj   +1 more source