Results 1 to 10 of about 14,331 (219)

Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand

Molecules, 2013
Pregnenolone sulfate is a steroid metabolite with a plethora of actions and functions. As a neurosteroid, pregnenolone sulfate modulates a variety of ion channels, transporters, and enzymes.
Christian Harteneck
exaly   +4 more sources

Pregnenolone Inhibits Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis—Role of Matrix Metalloproteinase 2 and NADPH Oxidase 1

Pharmaceuticals, 2023
The clinical usefulness of doxorubicin (DOX) is limited by its serious adverse effects, such as cardiotoxicity. Pregnenolone demonstrated both anti-inflammatory and antioxidant activity in animal models.
Mohamed A. Morsy, Seham A. Abdel-Gaber, Sahar A. Mokhemer, Mahmoud Kandeel, Wael F. Sedik, Anroop B. Nair, Katharigatta N. Venugopala, Hany Ezzat Khalil, Bandar E. Al-Dhubiab, Mervat Z. Mohamed   +9 more
doaj   +2 more sources

Mechanistic insights into pregnenolone-mediated conidiation inhibition in Fusarium oxysporum [PDF]

BMC Microbiology
Background Fusarium oxysporum (FO) is a plant pathogen that causes significant economic losses worldwide. Conidia are the primary source of FO infection and survival till the next generation.
Maria Ajmal, Keqiang Xu, Hang Gao, Yifan Xu, Adil Hussain, Hongge Chen   +5 more
doaj   +2 more sources

Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study [PDF]

The Journal of Headache and Pain, 2021
Background Neurosteroids affect the balance between neuroexcitation and neuroinhibition but have been little studied in migraine. We compared the serum levels of pregnenolone sulfate, pregnanolone and estradiol in women with menstrually-related migraine ...
Cecilia Rustichelli, Elisa Bellei, Stefania Bergamini, Emanuela Monari, Flavia Lo Castro, Carlo Baraldi, Aldo Tomasi, Anna Ferrari   +7 more
doaj   +2 more sources

A growth-coupled progesterone-responsive biosensor for high-throughput microfluidic screening in Saccharomyces cerevisiae [PDF]

Synthetic and Systems Biotechnology
Poor aqueous solubility of steroid precursors, such as pregnenolone and progesterone, limits microbial biotransformation and high-throughput strain screening, representing a bottleneck for strain improvement and potential industrial applications.To ...
Yucheng Hu, Jinde Chen, Shaofang Tian, Yang Zhang, Zhiqian Zhang, Ao Jiang, Yi-Rui Wu, Baoshun Zhang   +7 more
doaj   +2 more sources

Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations [PDF]

Frontiers in Endocrinology
BackgroundType 2 diabetes (T2D) is increasing its burden worldwide; therefore, research focused on its prediction and prevention is essential.MethodsWe performed an untargeted metabolomics analysis using ultra high-performance liquid chromatography-mass ...
Maria Barranco-Altirriba, Maria Barranco-Altirriba, Maria Barranco-Altirriba, Maria Barranco-Altirriba, Minerva Granado-Casas, Minerva Granado-Casas, Minerva Granado-Casas, Minerva Granado-Casas, Oscar Yanes, Oscar Yanes, Jordi Capellades, Jordi Capellades, Alexandra Junza, Alexandra Junza, Josep Franch-Nadal, Josep Franch-Nadal, Joan Vendrell, Joan Vendrell, Gemma Llauradó, Gemma Llauradó, Sergio Valdés, Sergio Valdés, Eva García-Escobar, Eva García-Escobar, Marcelino Bermúdez-López, Marcelino Bermúdez-López, José Manuel Valdivielso, Victor-Miguel López-Lifante, Victor-Miguel López-Lifante, Victor-Miguel López-Lifante, Cecilia Herrero-Alonso, Mireia Falguera, Mireia Falguera, Maria Belén Vilanova, Maria Belén Vilanova, Ingrid Arteaga, Ingrid Arteaga, Pere Torán-Monserrat, Pere Torán-Monserrat, Pere Torán-Monserrat, Alexandre Perera-Lluna, Alexandre Perera-Lluna, Alexandre Perera-Lluna, Esmeralda Castelblanco, Didac Mauricio, Didac Mauricio, Didac Mauricio, Didac Mauricio   +47 more
doaj   +2 more sources

Epigenetic dysregulation of steroidogenesis and neuroactive steroid deficiency in premature ovarian insufficiency: implications for neurodegenerative risk [PDF]

Biomarker Research
Premature ovarian insufficiency (POI) is associated with an increased risk of neurodegenerative diseases, but the underlying mechanisms remain unclear.
Qian Wang, Junyan Sun, Lulu Wang, Xuefeng Lin, Liutong Wei, Qiuwan Zhang, Shuang Yuan, Dedong Xin, Dongmei Lai   +8 more
doaj   +2 more sources

Alcohol and pregnenolone interaction on cerebral arteries through targeting of vascular smooth muscle Ca2+- and voltage-gated K+ channels of big conductance

Advances in Drug and Alcohol Research, 2023
Despite the significant number of people who may be taking pregnenolone supplements while drinking alcohol (ethanol), the widely documented cerebrovascular actions of pregnenolone and ethanol, and the critical dependence of cerebrovascular function on ...
Kelsey C. North, Andrew A. Shaw, Luiz Moreira, Anna N. Bukiya, Alex M. Dopico   +4 more
doaj   +1 more source

Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder

Biomolecules, 2022
Chronic cocaine use leads to adaptations in stress biology and in neuroactive steroid system. These adaptations are associated with high cocaine craving and increased relapse risk.
Verica Milivojevic, Lily Charron, Nia Fogelman, Gretchen Hermes, Rajita Sinha   +4 more
doaj   +1 more source

Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice.

PLoS ONE, 2012
Pregnenolone belongs to a class of endogenous neurosteroids in the central nervous system (CNS), which has been suggested to enhance cognitive functions through GABA(A) receptor signaling by its metabolites.
Peiyan Wong, Cecilia Chin Roei Chang, Christine E Marx, Marc G Caron, William C Wetsel, Xiaodong Zhang   +5 more
doaj   +1 more source