Results 31 to 40 of about 14,331 (219)
The endogenic neurosteroid system and its role in the pathogenesis and therapy of mental disorders
Research Results in Pharmacology, 2023 Introduction: Although neurosteroids have been relatively recently discovered, their significant role in the neurochemical processes and pathogenesis of a number of psychiatric and neurological disorders is now quite clear.
Sakeena P. Bairamova +7 more
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Frontiers in Immunology, 2023 Pregnenolone (P5) is synthesized as the first bioactive steroid in the mitochondria from cholesterol. Clusters of differentiation 4 (CD4+) and Clusters of differentiation 8 (CD8+) immune cells synthesize P5 de novo; P5, in turn, play important role in ...
Sougata Roy +9 more
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Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]
, 2006 Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Eser, Daniela +9 more
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Sex differences in pregnenolone sulphate in the chick brain after training
, 2005 Pregnenolone and pregnenolone sulphate are potent memory enhancers when administered to rodents prior to various learning and memory paradigms. Here, we show that training on a passive avoidance task results in the increased concentration of pregnenolone
Rose, SPR, Johnston, ANB, Migues, PV
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eLife, 2020 The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in the zebrafish and revealed an unexpected role of this pathway in vertebrate embryonic development.
Meltem Weger +15 more
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Metabolism of pregnenolone-4-14C and pregnenolone-7[alpha]-3H sulfate by the Macaca mulatta fetal adrenal in vitro [PDF]
, 1971 These studies were initiated to ascertain the feasibility of utilizing the fetal monkey adrenal as a model for further studies on comparative steroid metabolism at various periods of gestation.
Snyder, Donald L. +3 more
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Cell Reports, 2014 T helper 2 (Th2) cells regulate helminth infections, allergic disorders, tumor immunity, and pregnancy by secreting various cytokines. It is likely that there are undiscovered Th2 signaling molecules.
Bidesh Mahata +12 more
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Activation of ciliary channels by pregnenolone sulfate.
, 2019 (A) The top recording shows the activity of a single ciliary channel observed while recording in the standard solutions (with 0.1 μM cytoplasmic free Ca2+). The bottom recording shows increased channel activity in the same cilium 5 min after perfusion of
Bradley P. Dixon (356752) +6 more
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N,N-Bis(3β-acetoxypregn-5(6)-en-20-on-16α-yl)hydroxylamine
Molbank, 2015 A steroid with the dimeric structure, N,N-bis(3β-acetoxypregn-5(6)-en-20-on-16α-yl)hydroxylamine was synthesized in the base catalyzed reaction of 3β-acetoxypregn-5,16-dien-20-one with O-(trimethylsilyl)hydroxylamine.
Rita Skoda-Földes
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