Results 31 to 40 of about 15,454 (206)

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone [PDF]

, 2012
Transient Receptor Potential Melastatin 3 (TRPM3) is a widely expressed calcium-permeable non-selective cation channel that is stimulated by high concentrations of nifedipine or by physiological steroids that include pregnenolone sulphate. Here we sought
Picton, Helen M., Beech, David J., Victoria A.L. Seymour, Tumova, Sarka, Yasser Majeed, David J. Beech, Fishwick, Colin W.G., Seymour, Victoria A.L., Katsuhiko Muraki, Porter, Karen E., Shannon Jiang, Sarka Tumova, Daniel M. Woods, Anil K. Agarwal, O’Regan, David J., Colin W.G. Fishwick, Jacqueline Naylor, Agarwal, Anil K., Green, Ben L., Ben L. Green, Muraki, Katsuhiko, Karen E. Porter, Helen M. Picton, Majeed, Yasser, Jiang, Shannon, David J. O’Regan, Woods, Daniel M., Naylor, Jacqueline   +27 more
core   +1 more source

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

eLife, 2020
The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in the zebrafish and revealed an unexpected role of this pathway in vertebrate embryonic development.
Meltem Weger, Benjamin D Weger, Andrea Schink, Masanari Takamiya, Johannes Stegmaier, Cédric Gobet, Alice Parisi, Andrei Yu Kobitski, Jonas Mertes, Nils Krone, Uwe Strähle, Gerd Ulrich Nienhaus, Ralf Mikut, Frédéric Gachon, Philipp Gut, Thomas Dickmeis   +15 more
doaj   +1 more source

Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease [PDF]

, 2023
Growing preclinical and clinical evidence highlights neurosteroid pathway imbalances in Parkinson's Disease (PD) and L-DOPA-induced dyskinesias (LIDs).
Caruso, Donatella, Mauro Gentile, Cioffi, Lucia,, Diviccaro, Silvia,, Silvia Fanni, Giulia Braccagni, Melcangi, R. C., Sara Corsi, Roberto Frau, Scheggi, Simona, Melcangi, Roberto Cosimo,, Corsi, Sara, Carta, Manolo,, Gambarana, Carla, Braccagni, Giulia,, Fanni, Silvia,, Cioffi, Lucia, Roberto Stancampiano, Fanni, Silvia, Corsi, Sara,, Gentile, Mauro,, Gambarana, Carla,, Carta, Manolo, Pardu, Alessandra,, Manolo Carta, Frau, Roberto,, Donatella Caruso, Lucia Cioffi, Stancampiano, Roberto,, Carla Gambarana, Scheggi, Simona,, Pardu, Alessandra, Roberto Cosimo Melcangi, Stancampiano, Roberto, Simona Scheggi, Alessandra Pardu, Silvia Diviccaro, Melcangi, Roberto Cosimo, Frau, Roberto, Gentile, Mauro, Caruso, Donatella,, Lund University., Braccagni, Giulia, Diviccaro, Silvia   +43 more
core   +1 more source

N,N-Bis(3β-acetoxypregn-5(6)-en-20-on-16α-yl)hydroxylamine

Molbank, 2015
A steroid with the dimeric structure, N,N-bis(3β-acetoxypregn-5(6)-en-20-on-16α-yl)hydroxylamine was synthesized in the base catalyzed reaction of 3β-acetoxypregn-5,16-dien-20-one with O-(trimethylsilyl)hydroxylamine.
Rita Skoda-Földes
doaj   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie International Edition, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +1 more source

Activation of ciliary channels by pregnenolone sulfate.

, 2019
(A) The top recording shows the activity of a single ciliary channel observed while recording in the standard solutions (with 0.1 μM cytoplasmic free Ca2+). The bottom recording shows increased channel activity in the same cilium 5 min after perfusion of
Bradley P. Dixon (356752), Julio A. Landero-Figueroa (6475778), Lu Lu (392), Nolan W. Pachciarz (6475781), Steven J. Kleene (233875), Nancy K. Kleene (323172), Brian J. Siroky (356756)   +6 more
core   +1 more source

Metabolism of pregnenolone-4-14C and pregnenolone-7[alpha]-3H sulfate by the Macaca mulatta fetal adrenal in vitro [PDF]

, 1971
These studies were initiated to ascertain the feasibility of utilizing the fetal monkey adrenal as a model for further studies on comparative steroid metabolism at various periods of gestation.
Snyder, Donald L., Jaffe, Robert B., Lindholm, Ulla B., Hugh Gorwill, R.   +3 more
core   +1 more source

Modular Synthesis of α‐Quaternary Pyrrolines by Pyridoxal‐Catalyzed Sequential Reactions With Precise Chirality Relay

Transformative Chemistry, EarlyView.
Direct asymmetric α‐C conjugate addition of aminoacetonitrile enabled by carbonyl/iminium double activation, together with subsequent electrophilic functionalization, offers a one‐pot, two‐step modular strategy for synthesizing chiral α‐quaternary pyrrolines with precise chirality relay and high structural diversity.
Xingdie Yang, Pengwei Ji, Liang Liu, Tongyin Chen, Siqi Liu, Wen‐Wen Chen, Baoguo Zhao   +6 more
wiley   +1 more source

Chemiluminescence immunoassay for pregnenolone [PDF]

, 1996
A double-antibody precipitation method has been developed to separate the antibody-bound and free analyte in a chemiluminescence immunoassay for the steroid hormone pregnenolone.
Curtin, William D.
core  

Forgetting in obesity: The pregnenolone link

Cell Metabolism, 2022
Cognitive dysfunction is often diagnosed in people with obesity and associated metabolic disorders. In the latest issue of Cell Metabolism, Ramírez et al. highlight an impaired production of the neurosteroid pregnenolone in the hypothalamus as a mechanism for obesity-induced cognitive impairment in both rodent models and patients with obesity.
Bellocchio, Luigi, Marsicano, Giovanni
openaire   +2 more sources