Results 11 to 20 of about 14,331 (219)

Inhibition by Pregnenolone Sulphate, a Metabolite of the Neurosteroid Pregnenolone, of Voltage-Gated Sodium Channels Expressed in Xenopus Oocytes

Journal of Pharmacological Sciences, 2012
Neurosteroids are known as allosteric modulators of the ligand-gated ion channel superfamily. Voltage-gated sodium channels (Nav) play an important role in mediating excitotoxic damages. Here we report the effects of neurosteroids on the function of Nav,
Takafumi Horishita, Susumu Ueno, Nobuyuki Yanagihara, Yuka Sudo, Yasuhito Uezono, Dan Okura, Takeyoshi Sata   +6 more
doaj   +2 more sources

Pregnenolone and pregnenolone sulfate metabolism by human fetal testes in vitro [PDF]

Steroids, 1970
Abstract Homogenates of testes from human fetuses of 12–16 weeks gestation were incubated in vitro with pregnenolone-4- 14 C and pregnenolone-7- 3 H-sulfate. Dehydroepiandrosterone sulfate and pregnenediol sulfate, each bearing the tritium label only, were identified in the conjugated fraction.
Lamont, Kenneth G., Perez-Palacios, Gregorio, Perez, Ana E., Jaffe, Robert B.   +3 more
openaire   +3 more sources

Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings

Life
Substance use disorders (SUDs), including cocaine use disorder (CUD), have significant negative health risks and impose a substantial social burden, yet effective treatments are limited.
Huaze Gao, Zachary Magin, Nia Fogelman, Rajita Sinha, Gustavo A. Angarita, Verica Milivojevic   +5 more
doaj   +2 more sources

Pregnenolone sulfate induces transcriptional and immunoregulatory effects on T cells [PDF]

Scientific Reports
Pregnenolone sulfate is a steroid metabolite of the steroidogenesis precursor, pregnenolone, with similar functional properties, including immunosuppression.
Yasmine El Hajj, Tala Shahin, Mame Massar Dieng, Manar Alshaikh, Mostafa Khair, Vinu Manikandan, Youssef Idaghdour   +6 more
doaj   +2 more sources

Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis [PDF]

Cells, 2020
Neurosteroids are steroids synthetized in the nervous system, with the first step of steroidogenesis taking place within mitochondria with the synthesis of pregnenolone. They exert important brain-specific functions by playing a role in neurotransmission,
Melissa Witzig, Amandine Grimm, Karen Schmitt, Imane Lejri, Stephan Frank, Steven A. Brown, Anne Eckert   +6 more
doaj   +2 more sources

The role of genetic polymorphisms in the sulfation of pregnenolone by human cytosolic sulfotransferase SULT2B1a

Scientific Reports
Pregnenolone is a key intermediate in the biosynthesis of many steroid hormones and neuroprotective steroids. Sulfotransferase family cytosolic 2B member 1 (SULT2B1a) has been reported to be highly selective to sulfate pregnenolone.
Eid Alatwi, Ahsan F. Bairam
doaj   +2 more sources

Deficient pregnenolone synthesis associated with congenital adrenal hyperplasia and organelle dysfunction

Endocrinology, Diabetes & Metabolism Case Reports, 2019
Steroid hormones are essential for the survival of all mammals. In adrenal glands and gonads, cytochrome P450 side chain cleavage enzyme (SCC or CYP11A1), catalyzes conversion of cholesterol to pregnenolone.
Himangshu S Bose, Alan M Rice, Brendan Marshall, Fadi Gebrail, David Kupshik, Elizabeth W Perry   +5 more
doaj   +2 more sources

TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan

BMC Musculoskeletal Disorders, 2010
Background Calcium-permeable channels are known to have roles in many mammalian cell types but the expression and contribution of such ion channels in synovial cells is mostly unknown.
English Anne A, Sukumar Piruthivi, Naylor Jacqueline, Majeed Yasser, Ciurtin Coziana, Emery Paul, Beech David J   +6 more
doaj   +2 more sources

Pregnenolone and progesterone production from natural sterols using recombinant strain of Mycolicibacterium smegmatis mc2 155 expressing mammalian steroidogenesis system

Microbial Cell Factories
Background Pregnenolone and progesterone are the life-important steroid hormones regulating essential vital functions in mammals, and widely used in different fields of medicine.
Mikhail Karpov, Nicolai Strizhov, Ludmila Novikova, Tatyana Lobastova, Sergey Khomutov, Andrei Shutov, Alexey Kazantsev, Marina Donova   +7 more
doaj   +2 more sources

Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers [PDF]

, 2023
Steroid hormone levels are closely related to the endogenous circadian rhythm induced by sleep–wake and dark–light cycles. Shift work that disrupts the circadian rhythm may influence the levels of steroid hormones.
Laura Zingaretti, Ermanno Vitale, Amati, Monica, Raffaella Lazzarini, Medori, Anna Rita, Massimo Bracci, Zingaretti, Laura, Santarelli, Lory, Caterina Ledda, Lazzarini, Raffaella, Gianmaria Salvio, Milinkovic, Marijana, Monica Amati, Salvio, Gianmaria, Alfio Ulissi, Margherita Martelli, Martelli, Margherita, Marijana Milinkovic, Ledda, Caterina, Bracci, Massimo, Vitale, Ermanno, Lory Santarelli, Ulissi, Alfio, Anna Medori   +23 more
core   +1 more source