Results 41 to 50 of about 14,331 (219)

Microbial keystone taxa and metabolic signatures in centenarians regulate intestinal homeostasis during aging

iMeta, EarlyView.
Clostridium scindens and its metabolite indole‐3‐acetic acid (IAA) are identified as a keystone taxon and metabolic signature in centenarians. Clostridium scindens enhances microbial network stability and produces IAA via its own amidase (AMIE) and aldehyde dehydrogenase (ALDH), thus promoting intestinal homeostasis by activating the aryl hydrocarbon ...
Wei‐Chuan Lin, Cui Zhang, He‐Hua Lei, Zheng Cao, Xin Gao, Wen‐Kai Yu, Xin‐Zhi Li, Qing‐Wei Xiang, Zhi‐Wen Zhang, Shi‐Fu Pang, Wei‐Fei Luo, Deng‐Hui Xie, Li‐Min Zhang, Gang Chen   +13 more
wiley   +1 more source

Steroidopathies and hormonal imbalance in children and adolescents with autism spectrum disorder

JCPP Advances, EarlyView.
Abstract Background Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with a multifactorial etiology, many aspects of which remain unclear. Emerging evidence suggests a potential association between ASD and clinical manifestations resulting from hormonal imbalances, henceforth named “steroidopathies.” The present study aims to ...
Concetta de Giambattista, Patrizia Ventura, Samuele Cortese, Paolo Trerotoli, Alessandra Di Gioia, Lucia Margari   +5 more
wiley   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Neurosteroids Progesterone and Dehydroepiandrosterone: Molecular Mechanisms of Action in Neuroprotection and Neuroinflammation

Pharmaceuticals
Neurosteroids pregnenolone, progesterone, allopregnanolone, and dehydroepiandrosterone have been actively studied in the last years as candidates for the treatment of neurodegenerative diseases and postinjury rehabilitation.
Tatiana A. Fedotcheva, Nikolay L. Shimanovsky   +1 more
doaj   +1 more source

Synthesis and Evaluation of Some 17-Acetamidoandrostane and N,N-Dimethyl-7-deoxycholic Amide Derivatives as Cytotoxic Agents: Structure/Activity Studies

Molecules, 2013
Using pregnenolone and 7-deoxycholic acid as starting materials, some 17-acetamidoandrostane and N,N-dimethyl-7-deoxycholic amide derivatives were synthesized. The cytotoxicity of the synthesized compounds was tested in vitro against two tumor cell lines:
Aimin Zhou, Chun Zeng, Huacan Song, Chunfang Gan, Linyi Jia, Jianguo Cui, Yanmin Huang   +6 more
doaj   +1 more source

Evaluation of a non‐radioactive rapid test for determination of serum progesterone in South American camelids

Veterinary Record, EarlyView.
Abstract Background Determination of the serum progesterone (P4) concentration is of high importance in reproductive medicine and may be applied for diagnosing pregnancy in South American camelids. P4 measurements in alpacas and llamas are usually performed using immunoassays, which are time consuming and require appropriate expertise of laboratory ...
Lina Längerer, Gerhard Schuler, Philipp Pohlscheid, Henrik Wagner, Kathrin Büttner, Axel Wehrend   +5 more
wiley   +1 more source

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone

, 2012
Transient Receptor Potential Melastatin 3 (TRPM3) is a widely expressed calcium-permeable non-selective cation channel that is stimulated by high concentrations of nifedipine or by physiological steroids that include pregnenolone sulphate. Here we sought
Picton, Helen M., Beech, David J., Victoria A.L. Seymour, Tumova, Sarka, Yasser Majeed, David J. Beech, Fishwick, Colin W.G., Seymour, Victoria A.L., Katsuhiko Muraki, Porter, Karen E., Shannon Jiang, Sarka Tumova, Daniel M. Woods, Anil K. Agarwal, O’Regan, David J., Colin W.G. Fishwick, Jacqueline Naylor, Agarwal, Anil K., Green, Ben L., Ben L. Green, Muraki, Katsuhiko, Karen E. Porter, Helen M. Picton, Majeed, Yasser, Jiang, Shannon, David J. O’Regan, Woods, Daniel M., Naylor, Jacqueline   +27 more
core   +1 more source

First Non‐Invasive Monitoring of Fecal Steroids in Greater Caribbean Manatees (Trichechus manatus manatus)

Zoo Biology, EarlyView.
This study established the first fecal hormonal reference values (P4/E2) for the Greater Caribbean manatee. Using non‐invasive ELISA, the authors found no significant differences between mature and immature females, highlighting that long‐term monitoring and ultrasounds are essential to fully understand their complex reproductive cycles.
Vanessa Bermúdez‐Cardona, Roberto Sánchez‐Okrucky, José A. Sandoval‐Zárate, Nataly Castelblanco‐Martínez   +3 more
wiley   +1 more source

Pregnenolone can protect the brain from cannabis intoxication

, 2014
Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa (marijuana), Δ(9)-tetrahydrocannabinol ...
Vallée, Monique, Umberto Spampinato, Maldonado, Rafael, 1961-, Sergio Vitiello, Sandy Fabre, Pier Vincenzo Piazza, Panin, Francesca, Valérie Roullot-Lacarrière, Bellocchio, Luigi, Hebert-Chatelain, Etienne, Marsicano, Giovanni, Diane L. Lynch, Jean-Michel Revest, Spampinato, Umberto, Etienne Hébert-Chatelain, Ross, Ruth, Maldonado, Rafael, Rafael Maldonado, Monlezun, Stéphanie, Martin-Garcia, Elena, Stéphanie Monlezun, Piazza, Pier Vincenzo, Fabre, Sandy, Elena Martin-Garcia, Baillie, Gemma, Fernando Kasanetz, Francesca Panin, Kasanetz, Fernando, Véronique Deroche-Gamonet, Deroche-Gamonet, Véronique, Monique Vallée, Adeline Cathala, Ruth A. Ross, Vitiello, Sergio, Dow P. Hurst, Roullot-Lacarrière, Valérie, Revest, Jean-Michel, Lynch, Diane, Giovanni Marsicano, Shore, Derek, Luigi Bellocchio, Cathala, Adeline, Patricia H. Reggio, Reggio, Patricia, Gemma L. Baillie, Martín García, Elena, 1975-, Hurst, Dow, Derek M. Shore   +47 more
core   +1 more source

Niemann-Pick Type C2 protein contributes to the transport of endosomal cholesterol to mitochondria without interacting with NPC1[S]

Journal of Lipid Research, 2012
Mitochondrial cholesterol is maintained within a narrow range to regulate steroid and oxysterol synthesis and to ensure mitochondrial function. Mitochondria acquire cholesterol through several pathways from different cellular pools.
Barry E. Kennedy, Mark Charman, Barbara Karten   +2 more
doaj   +1 more source