Results 61 to 70 of about 15,454 (206)
Cell Reports, 2014 T helper 2 (Th2) cells regulate helminth infections, allergic disorders, tumor immunity, and pregnancy by secreting various cytokines. It is likely that there are undiscovered Th2 signaling molecules.
Bidesh Mahata +12 more
doaj +1 more source
The role of iron in normal and impaired testicular function
Andrology, Volume 14, Issue 8, Page 2373-2387, November 2026.Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer +2 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 21, Page 6481-6500, November 2026.Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley +1 more source
Pharmaceuticals, 2018 The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone.
Mónica Fernández-Cancio +9 more
doaj +1 more source
Endocrinology, Diabetes & Metabolism Case Reports, 2019 Steroid hormones are essential for the survival of all mammals. In adrenal glands and gonads, cytochrome P450 side chain cleavage enzyme (SCC or CYP11A1), catalyzes conversion of cholesterol to pregnenolone.
Himangshu S Bose +5 more
doaj +1 more source
Veterinary Record, Volume 199, Issue 7, Page e327-e330, 3/10 October 2026.Abstract Background Determination of the serum progesterone (P4) concentration is of high importance in reproductive medicine and may be applied for diagnosing pregnancy in South American camelids. P4 measurements in alpacas and llamas are usually performed using immunoassays, which are time consuming and require appropriate expertise of laboratory ...
Lina Längerer +5 more
wiley +1 more source
Botanical, Phytochemistry, Pharmacology and Applications of Genus Heracleum: A Review
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.This manuscript presents a comprehensive review of plant species in the genus Heracleum, from botanical classification and distribution to medicinal uses, phytochemistry, pharmacology, and applications, aiming to provide references for further exploration of their therapeutic value and research development.
Nan Zhang +5 more
wiley +1 more source
Inhibition of testosterone biosynthesis by ethanol: relation to the pregnenolone-to-testosterone pathway [PDF]
, 1984 The concentrations of metabolites in the pregnenolone → testosterone pathway were determined in freezestopped testes in control rats and during ethanol intoxication (2 h after injection of 1.5 g ethanolkg body wt).
T.V. Widenius +9 more
core +1 more source
BMC Musculoskeletal Disorders, 2010 Background Calcium-permeable channels are known to have roles in many mammalian cell types but the expression and contribution of such ion channels in synovial cells is mostly unknown.
English Anne A +6 more
doaj +1 more source
Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +1 more source