Results 71 to 80 of about 15,454 (206)
Dependence of channel activation on voltage and pregnenolone sulfate concentration.
, 2019 (A) Channel open probability was measured as a function of membrane potential. Cytoplasmic solutions contained 0.1 μM free Ca2+. The pipette contained pregnenolone sulfate (0 μM to 75 μM as indicated) dissolved in an external solution that also contained
Bradley P. Dixon (356752) +6 more
core +1 more source
Microbial Cell Factories, 2018 Background Metabolic activities of microorganisms to modify the chemical structures of organic compounds became an effective tool for the production of high-valued steroidal drugs or their precursors.
Alina Świzdor +2 more
doaj +1 more source
Influência dos neuroesteróides sobre a tolerância ao etanol em camundongos / [PDF]
, 1999 Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências ...
Barbosa, Adriana Dias Elpo
core
Molecular Medicine, 2019 Background Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a complex multifactorial disorder of unknown cause having multi-system manifestations.
H. Cabanas +5 more
doaj +1 more source
Microbial Hydroxylation of Pregnenolone Derivatives
Chemical and Pharmaceutical Bulletin, 2005 Pregnenolone and pregnenolone acetate were incubated with the fungi Cunninghamella elegans, Rhizopus stolonifer and Gibberella fujikuroi. Incubation of with C. elegans yielded metabolites, 3beta,7beta,11alpha-trihydroxypreg-5-en-20-one, 3beta,6alpha,11alpha,12beta,15beta-pentahydroxypreg-4-en-20-one and 3beta,6beta,11alpha-trihydroxypreg-4-en-20-one ...
Choudhary, Muhammad Iqbal +4 more
openaire +3 more sources
Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]
, 2006 Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Eser, Daniela +9 more
core +1 more source
Effect of calcium ionophore A23187 on pregnenolone metabolism to progesterone in rat granulosa cells
, 1988 The effect of calcium ionophore A23187 on the metabolism of pregnenolone to progesterone was examined in rat granulosa cells during a 24-h culture period.
Benjamin K. Tsang +3 more
core +1 more source
The TRPP2-dependent channel of renal primary cilia also requires TRPM3.
PLoS ONE, 2019 Primary cilia of renal epithelial cells express several members of the transient receptor potential (TRP) class of cation-conducting channel, including TRPC1, TRPM3, TRPM4, TRPP2, and TRPV4.
Steven J Kleene +6 more
doaj +1 more source
A Comparison of Salivary Steroid Levels during Diagnostic Tests for Adrenal Insufficiency
Prague Medical Report, 2016 Numerous diagnostic tests are used to evaluate the hypothalamic-pituitary-adrenal axis (HPA axis). The gold standard is still considered the insulin tolerance test (ITT), but this test has many limitations.
Michaela Dušková +12 more
doaj +1 more source
GABAergic neuroactive steroids: a new frontier in bipolar disorders?
Behavioral and Brain Functions, 2012 Neurosteroids are synthesized in the brain and modulate brain excitability. There is increasing evidence of their sedative, anesthetic and antiseizure properties, as well as their influence on mood.
Carta Mauro Giovanni +2 more
doaj +1 more source