Results 91 to 100 of about 14,331 (219)

A Regioselective Synthesis of E-Guggulsterone

Molecules, 2011
We have successfully prepared E-guggulsterone from 16,17-epoxy-pregnenolone in 84% yield over two steps via a hydrazine reduction and Oppenhauer oxidation.
Jungyeob Ham, Jungwook Chin, Heonjoong Kang   +2 more
doaj   +1 more source

The Spontaneous Ala147Thr Amino Acid Substitution within the Translocator Protein Influences Pregnenolone Production in Lymphomonocytes of Healthy Individuals

, 2009
The de novo production of steroids and neurosteroids begins in mitochondria by the conversion of cholesterol to pregnenolone through cytochrome P450 side-chain cleavage (CYP11A1) enzymatic activity.
MARTINI, CLAUDIA, LARI L, PINI, STEFANO, CASSANO, GIOVANNI BATTISTA, DA POZZO, ELEONORA, ABELLI M, PREVE M, COSTA, BARBARA, GABELLONI P, LUCACCHINI, ANTONIO   +9 more
core   +1 more source

The Fungus Trichoderma Regulates Submerged Conidiation Using the Steroid Pregnenolone

, 2016
In previous work, we evolved a population of Trichoderma citrinoviride in liquid cultures to speed up its asexual development cycle. The evolved population, called T-6, formed conidia 3 times sooner and in >1000-fold greater numbers.
Michael Travisano (234511), Hui Lin (161703), Romas J. Kazlauskas (1419961)   +2 more
core   +1 more source

Gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life

Neuropsychiatric Disease and Treatment, 2018
Chien-Yu Chen,1 Chih-Ching Wu,2,3 Yu-Chi Huang,1 Chi-Fa Hung,1 Liang-Jen Wang4 1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; 2Molecular Medicine Research Center, Chang ...
Chen CY, Wu CC, Huang YC, Hung CF, Wang LJ   +4 more
doaj  

ANTIMICROBIAL ACTIVITY OF PREGNENOLONE-CARBAMAZEPINE COMPLEX ON

, 2020
In this work the antibacterial activity of pregnenolone-carbamazepine complex was evaluated on S. Aureus, K. pneumoniae and E. coli. The evaluation of antimicrobial effect of the different compounds on the bacterial species was made by the method of ...
María López-Ramos, E Coli, S Aureus, K Pneumoniae, Francisco Díaz-Cedillo, Lauro Figueroa-Valverde, Elodia Garcia-Cervera, Rogaciano Torres-Cruz, Jorge Reyna   +8 more
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Antibacterial activity of two pregnenolone-derivatives against Vibrio cholerae and Escherichia coli and its relationship with descriptors LogP, Π [PDF]

, 2011
In this work the antibacterial activity of two pregnenolone-derivatives was evaluated on V. cholerae and E. coli, using a NCCLS broth dilution modified method.
Díaz, Francisco, Camacho, Abelardo, García, Elodia, López, María, Ozaeta, Rolando, Figueroa, Lauro   +5 more
core  

Pregnenolone and pregnenolone-methyl-ether rescue neuronal defects caused by dysfunctional CLIP170 in a neuronal model of CDKL5 Deficiency Disorder

, 2020
Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene are responsible for the onset of CDKL5 Deficiency Disorder (CDD), a neurological pathology characterised by severe infantile seizures, intellectual disability, impairment of gross ...
Tramarin Marco, De Rosa Roberta, Bianchi Massimilliano, Siniscalchi Paolo, Barbiero Isabella, Peroni Diana, Rusconi Laura, Motta Paolo, Kilstrup-Nielsen Charlotte.   +8 more
core   +1 more source

Effects of genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by human cytosolic sulfotransferase SULT2A1

, 2018
The cytosolic sulfotransferase (SULT) SULT2A1 is known to mediate the sulfation of DHEA as well as some other hydroxysteroids such as pregnenolone. The present study was designed to investigate how genetic polymorphisms of the human SULT2A1 gene may ...
Amal A. El Daibani, Ming-Cheh Liu, Mohammed I. Rasool, Katsuhisa Kurogi, Saud A. Gohal, Fatemah A. Alherz, Maryam S. Abunnaja, Yoichi Sakakibara, Masahito Suiko, Ahsan F. Bairam   +9 more
core   +1 more source

Divergent mechanisms of steroid inhibition in the human ρ1 GABAA receptor

Nature Communications
ρ-type γ-aminobutyric acid-A (GABAA) receptors are widely distributed in the retina and brain, and are potential drug targets for the treatment of visual, sleep and cognitive disorders.
Chen Fan, John Cowgill, Rebecca J. Howard, Erik Lindahl   +3 more
doaj   +1 more source

The metabolism of pregnenolone in normal subjects and hypertensive individuals.

, 1969
We have adapted the double isotope derivative assay technique for the measurement of the excretion rate of delta-5-pregnenediol, and applied this method for a comparative study of the metabolism of pregnenolone in normal subjects and hypertensive ...
Silah, Jack G.
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