Results 101 to 110 of about 14,331 (219)

Determination kinetic parameters of 3 Beta-Hydroxy Steroid Dehydrogenase activity in testis of rat

مجله دانشگاه علوم پزشکی گرگان, 2002
3 Beta-Hydroxy-delta-5-steroid dehydrogenase is an important key enzyme of steroid hormone biosynthesis, which is involved in catalyzing the conversion of pregnenolone to progesterone in the biosynthesis of steroid sex hormones. This is the fourth enzyme
D.Qujeq
doaj  

Pregnenolone Overproduction in Yarrowia lipolytica by Integrative Components Pairing of the Cytochrome P450scc System

, 2019
Microbial production of steroid drugs exhibits great potentials in much greener and more sustainable manners, in which engineering multiple cytochrome P450s is the prerequisite requirement.
Hong Liu, Xiao Zhou, Mingdong Yao (3383978), Jinlai Zhang, Wenhai Xiao, Hong Liu (50694), Jinlai Zhang (7582313), Yu Zhang, Wenhai Xiao (3495275), Mingdong Yao, Ruosi Zhang (3700141), Yingjin Yuan (473679), Xiao Zhou (122661), Yu Zhang (12946), Yingjin Yuan, Ying Wang, Ying Wang (11406), Ruosi Zhang   +17 more
core   +1 more source

Pregnenolone can protect the brain from cannabis intoxication

Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa (marijuana), Δ(9)-tetrahydrocannabinol ...
Vallée, Monique, Piazza, Pier Vincenzo, Maldonado, Rafael, 1961-, Martín García, Elena, 1975-   +3 more
core  

Acute liver failure and hyperammonemia increase peripheral-type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain

, 1995
We investigated the role of brain peripheral-type benzodiazepine receptors (PBRs) and pregnenolone (a product of PBRs activation) in hepatic encephalopathy (HE)/hyperammonemia. Administration of the hepatotoxin, thioacetamide, or ammonium acetate to mice
Dombro, Roy S, Norenberg, Michael D, Roig-Cantisano, Ana, Itzhak, Yossef   +3 more
core   +1 more source

Pregnenolone Sulfate Activates Basic Region Leucine Zipper Transcription Factors in Insulinoma Cells: Role of Voltage- Gated Ca 2ϩ Channels and Transient Receptor Potential Melastatin 3 Channels □ S

, 2020
The neurosteroid pregnenolone sulfate activates a signaling cascade in insulinoma cells involving activation of extracellular signal-regulated protein kinase and enhanced expression of the transcription factor Egr-1.
Isabelle Mü, Oliver G Rö, Gerald Thiel
core  

Pregnenolone [PDF]

, 2020
openaire   +1 more source

In vitro metabolism of pregnenolone to 7 alpha-hydroxypregnenolone by rainbow trout embryos

, 2014
Tissues taken from rainbow trout embryos at several developmental stages, were incubated in the presence of radioactively-labelled pregnenolone in order to determine the capability of salmonid embryos to metabolize steroids, such as pregnenolone, that ...
Leatherland, J. F., Renaud, R. L., Petkam, R., Raeside, J. I., Freitas, A. M. M. S., Canario, Adelino V. M., Kime, D. E.   +6 more
core  

Effects of the neuroactive steroid precursor pregnenolone on stress- and alcohol cue-provoked pain responses in individuals with alcohol use disorder. [PDF]

Exp Clin Psychopharmacol
Quinlan R, Gao H, Sinha R, Milivojevic V.   +3 more
europepmc   +1 more source

Mammalian-like steroidogenesis in plants gives rise to endocrine-mimetic cardenolides. [PDF]

Sci Adv
Xu M, Kastner DW, Luo W, Li FS, Müller P, Sun Y, Huang W, Glinkerman CM, Guempel M, Kulik HJ, Weng JK.   +10 more
europepmc   +1 more source

Radioimmunoassay for Plasma Pregnenolone—Dexamethasone Suppressibility of Plasma Pregnenolone—

RADIOISOTOPES, 1978
Seikoh NISHIDA, Shigeichi MATSUMURA, Masaharu HORINO, Hideki OYAMA, Atsuko TENKU, Keiji KAKITA   +5 more
openaire   +3 more sources