Results 81 to 90 of about 15,454 (206)

Norepinephrine stimulates progesterone production in highly estrogenic bovine granulosa cells cultured under serum-free, chemically defined conditions

Reproductive Biology and Endocrinology, 2012
Background Since noradrenergic innervation was described in the ovarian follicle, the actions of the intraovarian catecholaminergic system have been the focus of a variety of studies.
Piccinato Carla A, Montrezor Luis H, Collares Cristhianna AV, Vireque Alessandra A, Rosa e Silva Alzira AM   +4 more
doaj   +1 more source

Gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life

Neuropsychiatric Disease and Treatment, 2018
Chien-Yu Chen,1 Chih-Ching Wu,2,3 Yu-Chi Huang,1 Chi-Fa Hung,1 Liang-Jen Wang4 1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; 2Molecular Medicine Research Center, Chang ...
Chen CY, Wu CC, Huang YC, Hung CF, Wang LJ   +4 more
doaj  

Pregnenolone and progesterone production from natural sterols using recombinant strain of Mycolicibacterium smegmatis mc2 155 expressing mammalian steroidogenesis system

Microbial Cell Factories
Background Pregnenolone and progesterone are the life-important steroid hormones regulating essential vital functions in mammals, and widely used in different fields of medicine.
Mikhail Karpov, Nicolai Strizhov, Ludmila Novikova, Tatyana Lobastova, Sergey Khomutov, Andrei Shutov, Alexey Kazantsev, Marina Donova   +7 more
doaj   +1 more source

Pregnenolone sulfate increases hippocampal acetylcholine release and spatial recognition.

, 2000
International audienceThe pregnenolone sulfate is a neurosteroid with promnesic properties. Recently, a correlation between endogenous levels of pregnenolone sulfate in the hippocampus and performance in a spatial memory task has been reported in aged ...
Darnaudéry, Muriel, Koehl, Muriel, Le Moal, Michel, Muriel Darnaudéry, Mayo, Willy, Muriel Koehl, Piazza, Pier-Vincenzo, Michel Le Moal, Willy Mayo, Pier-Vincenzo Piazza   +9 more
core   +1 more source

Metabolism of pregnenolone and its sulphate in normotensive control subject and patients with benign essential hypertension.

, 1973
The urinary excretion of total etiocholanolone and four delta5-3beta-hydroxysteroids viz, pregnenediol, 17alpha-hydroxy-pregnenolone, pregnenetriol and dehydroepiandrosterone isolated from the glucuronide and sulphate fractions by sequential hydrolysis ...
Tan, Eng L.
core  

Neuroprotection by the steroids pregnenolone and dehydroepiandrosterone is mediated by the enzyme aromatase

, 2013
Pregnenolone and dehydroepiandrosterone (DHEA) are sex hormone precursors and neuroprotective steroids. Effects of pregnenolone and DHEA may be in part mediated by their conversion to testosterone and by the consecutive conversion of testosterone to ...
García-Segura, Luis M., Azcoitia, I., Veiga, Sergio   +2 more
core   +1 more source

Divergent mechanisms of steroid inhibition in the human ρ1 GABAA receptor

Nature Communications
ρ-type γ-aminobutyric acid-A (GABAA) receptors are widely distributed in the retina and brain, and are potential drug targets for the treatment of visual, sleep and cognitive disorders.
Chen Fan, John Cowgill, Rebecca J. Howard, Erik Lindahl   +3 more
doaj   +1 more source

Determination kinetic parameters of 3 Beta-Hydroxy Steroid Dehydrogenase activity in testis of rat

مجله دانشگاه علوم پزشکی گرگان, 2002
3 Beta-Hydroxy-delta-5-steroid dehydrogenase is an important key enzyme of steroid hormone biosynthesis, which is involved in catalyzing the conversion of pregnenolone to progesterone in the biosynthesis of steroid sex hormones. This is the fourth enzyme
D.Qujeq
doaj  

Pregnenolone decreased the effect of Henkel 100-induced responses in the OE.

, 2016
(A) Representative submerged EOG responses to Henkel 100 (1:5,000) were recorded from the surface of the septum of female mice. Pregnenolone preincubation (1 μM) temporarily reduced the response amplitude.
Paul Scholz (683928), Hanns Hatt (120893), Maximilian Nagel (683926), Günter Gisselmann (120878), Julia Mohrhardt (3142071), Ninthujah Kanageswaran (683924)   +5 more
core   +1 more source

Pregnenolone separation from cholesterol using Sephadex LH-20 mini-columns

, 1980
This article reports a new procedure for the separation of radiolabeled pregnenolone and cholesterol using minicolumns of Sephadex LH-20 and a simple solvent system.
Jefcoate, Colin R., Israel Hanukoglu, Colin R. Jefcoate, Hanukoglu, Israel   +3 more
core   +1 more source