Biosynthesis and Industrial Production of Androsteroids
Plants, 2020 Steroids are a group of organic compounds that include sex hormones, adrenal cortical hormones, sterols, and phytosterols. In mammals, steroid biosynthesis starts from cholesterol via multiple steps to the final steroid and occurs in the gonads, adrenal ...
Rituraj Batth +3 more
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Gut Steroids and Microbiota: Effect of Gonadectomy and Sex
Biomolecules, 2022 Sex steroids, derived mainly from gonads, can shape microbiota composition; however, the impact of gonadectomy and sex on steroid production in the gut (i.e., gut steroids), and its interaction with microbiota composition, needs to be clarified.
Silvia Diviccaro +9 more
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The Ability of Pregnenolone in Proliferation of Mouse Neural Stem Cells and Reduction of Inflammatory and Oxidant Markers after Induction of Inflammation with Lipopolysaccharide in Vitro [PDF]
Armaghane Danesh Bimonthly Journal, 2023 Background & aim: Pregnenolone acts as a precursor to other steroid hormones and exerts its effect as an anti-inflammatory molecule to maintain immune homeostasis in various inflammatory conditions. In these diseases, a decrease in the level ofP has been
K Negintaji +3 more
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Analysis of salivary steroid hormones in boys with autism spectrum disorder
BMC Psychiatry, 2023 Background Autism spectrum disorders (ASD) is a neurodevelopmental disorder with high incidence rate and difficult diagnosis. The purpose of this study was to explore whether salivary cortisol, dehydroepiandrosterone (DHEA) and pregnenolone can be used ...
Qing He +9 more
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Applied Sciences, 2021 The response of synthetic substrates of sex steroid hormones—cholesterol (CHO), pregnenolone (PREG), and progesterone (PROG)—in the serum and testes of male tilapia (Oreochromis niloticus) to the environmental estrogen pesticide methomyl (0.2, 2, 20, and
Shunlong Meng +7 more
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Impact of Intraventricular Human Adipose-Derived Stem Cells Transplantation with Pregnenolone Treatment on Remyelination of Corpus Callosum in A Rat Model of Multiple Sclerosis [PDF]
Cell Journal, 2022 ObjectiveMultiple sclerosis (MS) is known as a nerve tissue disorder, which causes demyelination of central nervoussystem (CNS) fibers. Cell-based treatment is a novel strategy for the treatment of demyelinating diseases such asMS.
Mohammad Mardani +4 more
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Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease [PDF]
, 2023 Growing preclinical and clinical evidence highlights neurosteroid pathway imbalances in Parkinson's Disease (PD) and L-DOPA-induced dyskinesias (LIDs).
Caruso, Donatella +43 more
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Steroids and Brain, a Rising Bio-Medical Domain: a Perspective
Frontiers in Endocrinology, 2018 Some newly described steroid-related compounds, also found in the rest of the body, are formed and active in the central nervous system, particularly in the brain. Some are of pharmacological and physiopathological interest. We specifically report on two
Etienne-Emile Baulieu
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Biomolecules, 2022 The treatment with finasteride (i.e., an inhibitor of 5α-reductase) may be associated with different side effects (i.e., depression, anxiety, cognitive impairment and sexual dysfunction) inducing the so-called post finasteride syndrome (PFS).
Silvia Diviccaro +6 more
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Analysis of Corticosterone and Testosterone Synthesis in Rat Salivary Gland Homogenates
Frontiers in Endocrinology, 2019 Extra-adrenal steroid hormone production has been reported in several tissues, the biological role of which is interesting in terms of hormonal regulation of metabolism, growth, and behavior. In this report, we describe for the first time steroidogenesis
Takahiro Ieko +5 more
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