Results 11 to 20 of about 4,910 (136)

The endogenous cannabinoid system gates plasticity of tonic GABA inhibition. [PDF]

J Physiol
Abstract figure legend Postsynaptic depolarisation and increases in intracellular Ca2+ ([Ca2+]i) trigger the synthesis of endocannabinoids (eCBs), which are hypothesised to enhance tonic GABAergic inhibition via two primary pathways. In the proposed autocrine mechanism, eCBs activate postsynaptic somatodendritic or mitochondrial CB1 receptors ...
Colangeli R, Conti F.
europepmc   +2 more sources

Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause

Molecules, 2023
Women have a high susceptibility to the negative effects of stress. Hormonal changes experienced throughout their reproductive life partially contribute to a higher incidence of anxiety and depression symptoms, particularly, during natural or surgical ...
Luis Ángel Flores-Aguilar, Jonathan Cueto-Escobedo, Abraham Puga-Olguín, Oscar Jerónimo Olmos-Vázquez, Gilberto Uriel Rosas-Sánchez, Blandina Bernal-Morales, Juan Francisco Rodríguez-Landa   +6 more
doaj   +1 more source

Multiple functional neurosteroid binding sites on GABAA receptors.

PLoS Biology, 2019
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases.
Zi-Wei Chen, John R Bracamontes, Melissa M Budelier, Allison L Germann, Daniel J Shin, Krishnan Kathiresan, Ming-Xing Qian, Brad Manion, Wayland W L Cheng, David E Reichert, Gustav Akk, Douglas F Covey, Alex S Evers   +12 more
doaj   +1 more source

Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis

Frontiers in Cellular Neuroscience, 2015
Corticosterone is known to accumulate in brain after various stressors including alcohol intoxication. Just as severe alcohol intoxication is typically required to impair memory formation only high concentrations of ethanol (60mM) acutely inhibit long ...
Yukitoshi eIzumi, Kazuko A. O’Dell, Charles F. Zorumski   +2 more
doaj   +1 more source

Investigation of the Possible Allostery of Koumine Extracted From Gelsemium elegans Benth. And Analgesic Mechanism Associated With Neurosteroids

Frontiers in Pharmacology, 2021
Translocator protein 18 kDa (TSPO) is an evolutionarily conserved 5-transmembrane domain protein, and has been considered as an important therapeutic target for the treatment of pain.
Bojun Xiong, Bojun Xiong, Wenbing You, Yufei Luo, Guilin Jin, Guilin Jin, Minxia Wu, Ying Xu, Ying Xu, Jian Yang, Jian Yang, Huihui Huang, Changxi Yu, Changxi Yu   +13 more
doaj   +1 more source

Neurosteroids in Schizophrenia: Pathogenic and Therapeutic Implications

Frontiers in Psychiatry, 2018
Neurosteroids are a group of important endogenous molecules affecting many neural functions in the brain. Increasing evidence suggests a possible role of these neurosteroids in the pathology and symptomatology of schizophrenia (SZ) and other mental ...
HuaLin Cai, HuaLin Cai, Ting Cao, Ting Cao, Xiang Zhou, Xiang Zhou, Jeffrey K. Yao, Jeffrey K. Yao, Jeffrey K. Yao   +8 more
doaj   +1 more source

Neurosteroids as Selective Inhibitors of Glycine Receptor Activity: Structure-Activity Relationship Study on Endogenous Androstanes and Androstenes

Frontiers in Molecular Neuroscience, 2020
The ability of androstane and androstene neurosteroids with modifications at C-17, C-5, and C-3 (compounds 1-9) to influence the functional activity of inhibitory glycine and γ-aminobutyric acid (GABA) receptors was estimated.
Julia V. Bukanova, Elena I. Solntseva, Eva Kudova   +2 more
doaj   +1 more source

Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage

Frontiers in Pharmacology, 2021
Mesolimbic dopamine transmission is dysregulated in multiple psychiatric disorders, including addiction. Previous studies found that the endogenous GABAergic steroid (3α,5α)-3-hydroxy-5-pregnan-20-one (allopregnanolone) modulates dopamine levels in the ...
Ana Paula S. Dornellas, Ana Paula S. Dornellas, Giovana C. Macedo, Giovana C. Macedo, Minna H. McFarland, Alexander Gómez-A, Todd K. O’Buckley, Claudio Da Cunha, A. Leslie Morrow, A. Leslie Morrow, A. Leslie Morrow, Donita L. Robinson, Donita L. Robinson   +12 more
doaj   +1 more source

Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2

Molecules, 2021
In this study, we investigated the delivery of synthetic neurosteroids into MCF-7 human breast adenocarcinoma cells via Organic Anionic Transporting Polypeptides (OATPs) (pH 7.4 and 5.5) to identify the structural components required for OATP-mediated ...
Santosh Kumar Adla, Arun Kumar Tonduru, Thales Kronenberger, Eva Kudova, Antti Poso, Kristiina M. Huttunen   +5 more
doaj   +1 more source

Gestational or acute restraint in adulthood reduces levels of 5α-reduced testosterone metabolites in the hippocampus and produces behavioral inhibition of adult male rats

Frontiers in Cellular Neuroscience, 2012
Stressors, during early life or adulthood, can alter steroid-sensitive behaviors, such as exploration, anxiety, and/or cognitive processes. We investigated if exposure to acute stressors in adulthood may alter behavioral and neuroendocrine responses of ...
Alicia A Walf, Cheryl A Frye
doaj   +1 more source