Results 41 to 50 of about 5,061 (119)

Androgen Regulation of the Mesocorticolimbic System and Executive Function

Frontiers in Endocrinology, 2018
Multiple lines of evidence indicate that androgens, such as testosterone, modulate the mesocorticolimbic system and executive function. This review integrates neuroanatomical, molecular biological, neurochemical, and behavioral studies to highlight how ...
Daniel J. Tobiansky, Daniel J. Tobiansky, Kathryn G. Wallin-Miller, Stan B. Floresco, Stan B. Floresco, Ruth I. Wood, Kiran K. Soma, Kiran K. Soma, Kiran K. Soma   +8 more
doaj   +1 more source

Steroidogenic acute regulatory (StAR) protein expression in the central nervous system

Frontiers in Endocrinology, 2011
Locally produced neurosteroids are proposed to have many functions in the central nervous system. The identification of the steroidogenic acute regulatory (StAR) protein in steroid-producing neural cells provides a new tool to understand the sites ...
Steven R. King, Douglas M Stocco
doaj   +1 more source

Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders

Frontiers in Endocrinology, 2019
Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored ...
Marcia H. Ratner, Vidhya Kumaresan, David H. Farb   +2 more
doaj   +1 more source

The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder

Frontiers in Pharmacology, 2018
The translocator protein (18 kDa) (TSPO) recently attracted increasing attention in the pathogenesis of post-traumatic stress disorder (PTSD). This study is testing the hypothesis that the overexpression of TSPO in hippocampus dentate gyrus (DG) could ...
Xiao-Ying Zhang, Xiao-Ying Zhang, Wang Wei, You-Zhi Zhang, Qiang Fu, Wei-Dong Mi, Li-Ming Zhang, Yun-Feng Li   +7 more
doaj   +1 more source

Reduced Neurosteroid Exposure Following Preterm Birth and Its’ Contribution to Neurological Impairment: A Novel Avenue for Preventative Therapies

Frontiers in Physiology, 2019
Children born preterm are at an increased risk of developing cognitive problems and neuro-behavioral disorders such as attention deficit hyperactivity disorder (ADHD) and anxiety. Whilst neonates born at all gestational ages, even at term, can experience
Julia C. Shaw, Julia C. Shaw, Mary J. Berry, Mary J. Berry, Rebecca M. Dyson, Rebecca M. Dyson, Gabrielle K. Crombie, Gabrielle K. Crombie, Jonathan J. Hirst, Jonathan J. Hirst, Hannah K. Palliser, Hannah K. Palliser   +11 more
doaj   +1 more source

Zuranolone therapy protects frontal cortex neurodevelopment and improves behavioral outcomes after preterm birth

Brain and Behavior
Background Preterm birth is associated with brain injury and long‐term behavioral abnormalities, for which there are limited prevention options. When born preterm, infants prematurely lose placental neurosteroid (allopregnanolone) support. This increases
Roisin A. Moloney, Hannah K. Palliser, Carlton L. Pavy, Julia C. Shaw, Jonathan J. Hirst   +4 more
doaj   +1 more source

Animal models of catamenial epilepsy: Discovery of an extrasynaptic molecular mechanism for targeted therapy

Frontiers in Cellular Neuroscience, 2016
Catamenial epilepsy is a complex neuroendocrine condition in which seizures are clustered around specific points in the menstrual cycle, most often around perimenstrual or periovulatory period.
Doodipala Samba eReddy
doaj   +1 more source

Estradiol synthesis and action at the synapse: evidence for ‘synaptocrine’ signaling

Frontiers in Endocrinology, 2011
Classically, the modulation of brain function and behavior by steroid hormones was linked exclusively to secretion by peripheral endocrine glands. Subsequently, steroid actions within the brain were shown dependent upon either synthesis and secretion by ...
Luke eRemage-Healey, Colin J Saldanha, Barney A Schlinger   +2 more
doaj   +1 more source

Allopregnanolone and mood in the peripartum: a longitudinal assessment in healthy women

Frontiers in Behavioral Neuroscience
BackgroundAllopregnanolone (ALLO), a neuroactive steroid hormone derived from progesterone, can modulate mood via the GABA-A receptor. Peripartum mood can be influenced by psychosocial factors, previous mental illness, and hormonal changes.
Maria Katharina Grötsch, Ulrike Ehlert
doaj   +1 more source

The neurosteroid paradigm in perinatal depression: From pathophysiology to precision therapeutics. [PDF]

J Neuroendocrinol
Radonjić NV, Moon KC, Deligiannidis KM.
europepmc   +1 more source